Model catalog
Start with the biological or translational question. Explore curated starting configurations for 46 models, change inputs, and compare how model readouts respond.
Featured models
These models show distinct ways simulation can reduce uncertainty before committing to additional experiments.
Target-gated design
Target-Gated Cargo QSP
Explore UBI’s original reduced QSP model for target-gated opening, tumor retention, and systemic-versus-tumor receptor occupancy.
Dose and response
Nivolumab exposure and tumor-size dynamics
Reference paper ↗Start with an exposure–response workflow that turns a dosing question into an interpretable tumor-size trajectory.
Biomarker dynamics
Rituximab exposure and CD19-positive B-cell dynamics
Reference paper ↗Explore a compact PK/PD and target-mediated model with a clinically legible CD19-positive B-cell readout.
ADC development
HER2 ADC population PK
Reference paper ↗Use a population-PK and model-based meta-analysis starting point for comparing HER2-directed antibody–drug conjugates.
Translational bridging
Pediatric bevacizumab minimal PBPK
Reference paper ↗Inspect an adult-to-pediatric minimal-PBPK bridge with curated exposure comparisons and transparent scope limits.
Model search
46 models
Mechanistic mouse PBPK/QSP coupling whole-body AAV8 disposition, receptor-mediated cell entry, nuclear vector, nonlinear dose-dependent transgene expression, FcRn-aware trastuzumab PBPK, and delayed immune loss.
A generic dynamic model for exploring how a bifunctional ligand binds two finite membrane-site classes, forms a ternary bridge through either binary intermediate, and can enter a high-ligand hook regime.
Fixed-effect in vitro model linking CD3×5T4 immune-synapse formation to T-cell activation, differentiation, and delayed tumor-cell killing.
Mechanistic QSP model for an intravenously dosed biologic designed to remain closed systemically and open after engaging a tumor-enriched gate. It connects three-compartment disposition, reversible cargo accessibility, tumor retention, and central-versus-tumor receptor occupancy using transparent UBI-authored equations and synthetic exploratory assumptions.
Mechanistic rat QSP coupling whole-body AAV biodistribution, intracellular transduction, transgene-derived anti-TargetX mAb, FcRn-aware protein PBPK, TargetX binding, and detailed brain/CSF transport across 725 explicit scalar states.
A two-compartment population PK model representing atezolizumab disposition, clinical covariate effects, time-varying clearance, concentration, and interval exposure.
A TMDD PK/PD model coupling intravenous crenezumab disposition to free and antibody-bound amyloid-beta 1-40 and 1-42 turnover.
A two-compartment population PK model representing cemiplimab exposure, covariate-dependent disposition, and gradual time variation in clearance.
A two-compartment population PK model representing atezolizumab concentration and exposure with body weight, albumin, sex, and anti-therapeutic-antibody covariates.
A subcutaneous quasi-steady-state TMDD model coupling erenumab disposition to CGRP-receptor abundance, unbound antibody, drug-target complex, and cumulative exposure.
A minimal PBPK model connecting body-weight-scaled bevacizumab clearance and compartment volumes to central and peripheral antibody exposure.
A reduced dose–exposure model for the CD37-directed ADC naratuximab emtansine, representing plasma decline and cumulative exposure across dose levels.
A two-compartment population PK model representing pediatric atezolizumab exposure with body weight, albumin, tumor burden, and anti-drug-antibody effects on disposition.
A coupled PK/PD model linking circulating rituximab to CD19-positive B-cell depletion, cell-dependent drug loss, and gradual B-cell repopulation.
A subcutaneous PK/PD model linking secukinumab absorption and distribution to IL-17A pathway inhibition, delayed PASI response, and tolerance dynamics.
A two-compartment population PK model connecting pertuzumab dosing and lean-body-weight and albumin covariates to concentration and cumulative exposure during neoadjuvant therapy.
A PK/PD exposure-response model linking intravenous dazukibart disposition and IFN-beta binding to delayed changes in cutaneous, muscle, functional, and global disease assessments.
A coupled subcutaneous or intravenous PK/PD model linking mepolizumab absorption and distribution to concentration-dependent suppression and turnover of circulating eosinophils.
A population QSS-TMDD model coupling bevacizumab disposition to VEGF165 turnover, free antibody, target-bound complex, and total circulating VEGF165.
A reduced pediatric PBPK model connecting body-size-dependent antibody disposition to central and peripheral exposure and optional target binding.
A reduced PK/PD model linking ravulizumab exposure to concentration-dependent suppression and recovery of free complement C5.
A two-compartment PK model representing eculizumab central and peripheral disposition and cumulative exposure in generalized myasthenia gravis.
A two-compartment population PK model representing vedolizumab central and peripheral disposition, prior anti-TNF effects on clearance, concentration, and cumulative exposure.
A two-compartment population PK model coupling panitumumab distribution to parallel linear and saturable Michaelis–Menten elimination.
A two-compartment population PK model representing eculizumab or SB12 disposition, body-weight effects, disease-specific central volume, concentration, and cumulative exposure.
A reduced AUTOTAC PK/PD model linking ATC161 exposure to concentration-dependent degradation and recovery of alpha-synuclein aggregates.
A reduced QSP model connecting nivolumab exposure and PD-1 checkpoint inhibition to effector and regulatory T-cell dynamics, tumor-cell burden, and tumor regression.
A mechanistic pharmacodynamic model connecting PROTAC concentration, target and E3-ligase binding, catalytic degradation, protein turnover, and the high-concentration hook effect.
A QSS-TMDD model representing intravenous or subcutaneous befovacimab disposition, TFPI turnover, free antibody, and antibody–TFPI complex dynamics.
A two-compartment population PK model for inotuzumab ozogamicin with linear and time-dependent clearance and clinically relevant body-size and disease covariates.
A two-compartment population PK model linking pembrolizumab dosing, body-size effects on disposition, central and peripheral antibody amounts, concentration, and cumulative exposure.
A two-compartment PK/PD model coupling sutimlimab linear and nonlinear disposition to concentration-dependent recovery and turnover of hemoglobin.
A PK/PD model coupling dabigatran central, peripheral, and effect-site disposition to idarucizumab-associated reversal of the anticoagulation response in sheep.
A PK/PD model coupling dabigatran systemic and bypass-circuit disposition to effect-site concentration and idarucizumab exposure during cardiopulmonary bypass.
A translational PK/PD model coupling zenocutuzumab distribution and nonlinear clearance to concentration-dependent tumor-cell death and net tumor-volume dynamics.
A subcutaneous population PK model representing envafolimab absorption, systemic concentration, renal-function covariates, and time-varying clearance.
A reduced subcutaneous PK model representing certolizumab pegol absorption from a depot, systemic elimination, blood concentration, and cumulative exposure.
A two-compartment population PK model with intramuscular absorption for the long-acting antibody combination tixagevimab–cilgavimab and covariate-dependent bioavailability and disposition.
A reduced ADC–payload disposition model linking enfortumab vedotin concentration to formation and elimination of the released MMAE payload and their cumulative exposures.
A reduced pharmacodynamic turnover model representing the time course of PASI response toward an efalizumab-associated steady state.
A reduced tumor-growth model representing the balance between untreated tumor expansion and SKB264-associated tumor-cell killing.
A reduced plasma PK model representing first-order elimination, concentration, half-life, and cumulative exposure of a positively charged trastuzumab-vc-MMAE ADC.
A coupled subcutaneous PK and indirect-response model linking dupilumab exposure to EASI and IGA response dynamics while accounting for patient and disease covariates.
A cytokine-network QSP model coupling drug exposure to resting, activated, cytotoxic, and exhausted T cells and to IL-6, IL-10, IL-1beta, IFN-gamma, and TNF-alpha dynamics.
A two-compartment population PK model for HER2-directed antibody–drug conjugates, representing central and peripheral disposition, concentration, and cumulative exposure across dose levels.
An exposure-response model connecting nivolumab steady-state exposure to competing tumor shrinkage and progression processes and their resulting tumor-size trajectory.
