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Dazukibart fixed IFN-beta and clinical-score reference

Fixed base-table dazukibart PK, serum IFN-beta QSS turnover and eleven empirical clinical-score trajectories with separate drug and target accounting.

Early exposure-response modeling of an interferon-beta monoclonal antibody (dazukibart) in adults with dermatomyositis ↗

Journal of Pharmacokinetics and Pharmacodynamics

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How do the active and placebo contexts change modeled clinical scores?

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600 mg IV every four weeks ×3

Fixed supplied base-model inputs; clinical-score trajectories are conditional mathematical responses.

0–12 week

Scenario details

600 mg IV every four weeks ×3

Fixed supplied base-model inputs; clinical-score trajectories are conditional mathematical responses.

Readouts

Central conc · ug/mL
Central apparent serum concentration
Ifn free · pg/mL
Unbound IFN-beta concentration
End cdasi a · dimensionless
end cdasi a
End MMT8 · dimensionless
end mmt8
End phga · dimensionless
end phga

Study purpose

  • How do the model's key biological readouts change under 600 mg iv every four weeks ×3?

Assumptions

  • Interpret patterns within this model and starting configuration; do not treat them as clinical predictions or treatment recommendations.

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Simulation time
week
week
12 → 168

Time between reported samples.

week
0.25 → 1

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Biology

Fixed base-table dazukibart PK, serum IFN-beta QSS turnover and eleven empirical clinical-score trajectories with separate drug and target accounting.

Fixed base-table dazukibart PK, serum IFN-beta QSS turnover and eleven empirical clinical-score trajectories with separate drug and target accounting.

Model details

36 parameters · 21 states · 21 equations · 73 derived outputs

Classification & API access
Therapeutic
Dazukibart
Modality
Monoclonal antibody
Target
IFNB1, interferon-beta
Disease / scope
Dermatomyositis
ParameterDefaultUnitDescription
Base cdasi abase_cdasi_a24—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Base cdasibase_cdasi_d3.6—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Base enzymebase_enzyme1.19—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Base exgabase_exga3.06—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Base haqbase_haq34.6—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Base MMT8base_mmt8118—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Base phgabase_phga54.7—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Base ptgabase_ptga58.6—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Base SF36 mcsbase_sf36_mcs48.1—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Base SF36 pfdbase_sf36_pfd41—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Base tis phgabase_tis_phga4.95—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Systemic clearancecl_l_week1.13064L/weekFixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Dazukibart mw gdazukibart_mw_g_mol150000g/molFixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Dm ifnbase multiplierdm_ifnbase_multiplier34.5—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Emax cdasi aemax_cdasi_a-1—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Emax cdasiemax_cdasi_d-0.115—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Emax enzymeemax_enzyme-0.502—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Emax exgaemax_exga-1—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Emax haqemax_haq-0.712—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Emax MMT8emax_mmt80.185—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Emax phgaemax_phga-1—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Emax ptgaemax_ptga-0.806—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Emax SF36 mcsemax_sf36_mcs0—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Emax SF36 pfdemax_sf36_pfd0.0646—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Emax tis phgaemax_tis_phga-1—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Emaxnormemaxnorm0.562—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Ifnbaseifnbase_pg_ml0.0133pg/mLFixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Ifnkdegifnkdeg_week14771/weekFixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Ifnkintifnkint_week5.4181/weekFixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Absorption rate constantka_week1.78080000000000021/weekFixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Turnover loss ratekout_week0.2451/weekFixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Quasi-steady-state binding constantkss_pm80.2pMFixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Pboeffpboeff1.05—Fixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Intercompartmental clearanceq_l_week3.2927999999999997L/weekFixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Central distribution volumevc_l3.05LFixed supplied base-model coefficient; no editable control or fitting domain is assigned.
Peripheral distribution volumevp_l2.55LFixed supplied base-model coefficient; no editable control or fitting domain is assigned.

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