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Whole-body AAV8 gene-delivery and transgene-antibody PBPK

Mechanistic mouse PBPK/QSP coupling whole-body AAV8 disposition, receptor-mediated cell entry, nuclear vector, nonlinear dose-dependent transgene expression, FcRn-aware trastuzumab PBPK, and delayed immune loss.

Decoding Nonlinearities in AAV-Based Gene Therapy Using PBPK Modelling ↗
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MODEL IN MOTION 18 sec

How does AAV dose affect persistent antibody production?

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AAV8 2e10 vg/mouse IV

Rajwade 2026 fitted whole-body AAV8 and trastuzumab regimen at 2e10 vg per mouse.

0–504 hour

Scenario details

AAV8 2e10 vg/mouse IV

Rajwade 2026 fitted whole-body AAV8 and trastuzumab regimen at 2e10 vg per mouse.

Readouts

AAV8 in whole blood · vg/µL
Whole-blood vector genomes including plasma and central blood-cell-associated forms.
Perfused liver AAV8 · vg/ng DNA
Equation 43 tissue vector-genome readout for liver.
Plasma trastuzumab · µg/mL
Secreted transgene product in central plasma, assuming 150 kDa IgG.

Study purpose

  • How do vector biodistribution and transgene-derived trastuzumab evolve over 21 days?

Assumptions

  • Forward simulation in mice; the original fitted model has not been reproduced.

Reference data

  • Published figures provide digitized population summaries; point-by-point agreement has not been verified.

Inputs changed since the displayed result. Run to update the comparison.

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Scenario-controlled

AAV administered dose vg defining the modeled treatment input for the explored scenario.

—

Suggested: 1.00e+10–3.00e+10. You can explore beyond this range.

20000000000 → —
Published fitted

AAV immune deg coefficient used by the released system of model equations.

1/h

Suggested: 0.35–1.05. You can explore beyond this range.

0.7 → —

AAV knuc coefficient used by the released system of model equations.

1/h

Suggested: 0.0135–0.0405. You can explore beyond this range.

0.027 → —

Kprod max governing production or formation in the modeled biological process.

mol/h

Suggested: 6.40e-21–1.92e-20. You can explore beyond this range.

1.28e-20 → —

Mab immune maximum elimination rate coefficient used by the released system of model equations.

1/h

Suggested: 0.529–1.59. You can explore beyond this range.

1.058 → —
Simulation time
h
h
504 → 168

Time between reported samples.

h
6 → 1

2 changes · Variation 1

Continue in the background and keep the result.

Biology

AAV8-encoded trastuzumab initiates the modeled biology: Whole-body AAV8 biodistribution across 15 tissues, Receptor-mediated uptake and nuclear vector persistence, Dose-dependent transgene expression and secretion, FcRn-aware trastuzumab distribution and salvage, Vector and antibody immune-mediated clearance. Primary readouts are AAV8 in whole blood, Perfused liver AAV8, Plasma trastuzumab, Brain-interstitial trastuzumab, Delayed antibody immune loss.

AAV8-encoded trastuzumab initiates the modeled biology: Whole-body AAV8 biodistribution across 15 tissues, Receptor-mediated uptake and nuclear vector persistence, Dose-dependent transgene expression and secretion, FcRn-aware trastuzumab distribution and salvage, Vector and antibody immune-mediated clearance. Primary readouts are AAV8 in whole blood, Perfused liver AAV8, Plasma trastuzumab, Brain-interstitial trastuzumab, Delayed antibody immune loss.

Model details

292 parameters · 545 states · 545 equations · 6 derived outputs

Classification & API access
Therapeutic
AAV8-encoded trastuzumab
Modality
Gene-delivered antibody
Target
HER2 (antibody identity only, no target-binding module)
Disease / scope
Preclinical AAV-mediated antibody delivery (not disease-specific)
ParameterDefaultUnitDescription
AAV administered dose vgaav_administered_dose_vg200000000000—AAV administered dose vg defining the modeled treatment input for the explored scenario.
AAV immune degaav_immune_deg_h0.71/hAAV immune deg coefficient used by the released system of model equations.
AAV tissue-distribution coefficientaav_kd_copy_L720000000000001/LAAV tissue-distribution coefficient describing equilibrium binding affinity in the modeled interaction.
AAV degradation rateaav_kdeg_h1.00681/hAAV degradation rate governing loss, degradation, or removal in the modeled biological process.
AAV kintaav_kint_h11/hAAV kint coefficient used by the released system of model equations.
AAV knucaav_knuc_h0.0271/hAAV knuc coefficient used by the released system of model equations.
AAV dissociation rateaav_koff_h0.2481/hTable II rounds this estimate to 0.25 h^-1.
AAV association rateaav_kon_L_copy_h3.47e-15L/hAAV association rate governing molecular association in the binding model.
AAV krecaav_krec_h11/hAAV krec coefficient used by the released system of model equations.
AAV ktransaav_ktrans_h11/hAAV ktrans coefficient used by the released system of model equations.
AAV loss stopaav_loss_stop_h504hAAV loss stop coefficient used by the released system of model equations.
Bcq adiposebcq_adipose_L_h0.010989L/hBcq adipose coefficient used by the released system of model equations.
Bcq bonebcq_bone_L_h0.01242L/hBcq bone coefficient used by the released system of model equations.
Bcq brainbcq_brain_L_h0.009639L/hBcq brain coefficient used by the released system of model equations.
Bcq heartbcq_heart_L_h0.029862L/hBcq heart coefficient used by the released system of model equations.
Bcq kidneybcq_kidney_L_h0.056052L/hBcq kidney coefficient used by the released system of model equations.
Bcq large intestinebcq_large_intestine_L_h0.014148L/hBcq large intestine coefficient used by the released system of model equations.
Bcq liverbcq_liver_L_h0.008397L/hBcq liver coefficient used by the released system of model equations.
Bcq lungbcq_lung_L_h0.305289L/hBcq lung coefficient used by the released system of model equations.
Bcq musclebcq_muscle_L_h0.07047L/hBcq muscle coefficient used by the released system of model equations.
Bcq otherbcq_other_L_h0.01026L/hBcq other coefficient used by the released system of model equations.
Bcq pancreasbcq_pancreas_L_h0.005103L/hBcq pancreas coefficient used by the released system of model equations.
Bcq skinbcq_skin_L_h0.022761L/hBcq skin coefficient used by the released system of model equations.
Bcq small intestinebcq_small_intestine_L_h0.04752L/hBcq small intestine coefficient used by the released system of model equations.
Bcq spleenbcq_spleen_L_h0.006696L/hBcq spleen coefficient used by the released system of model equations.
Bcq thymusbcq_thymus_L_h0.000972L/hBcq thymus coefficient used by the released system of model equations.
Brain bbb fractionbrain_bbb_fraction0.8611—Brain bbb fraction represented as a dimensionless fraction in the released equations.
Brain lv fractionbrain_lv_fraction0.5—Brain lv fraction represented as a dimensionless fraction in the released equations.
Clupclup_L_h_L1.093L/h/LClup coefficient used by the released system of model equations.
Clup brainclup_brain_L_h_L0.0305L/h/LClup brain coefficient used by the released system of model equations.
Dose scale AAV plasmadose_scale_aav_plasma_per_L1058.9294223541/LDose scale AAV plasma defining the modeled treatment input for the explored scenario.
FcRn dissociation ratefcrn_koff_h6.551/hFcRn dissociation rate governing molecular dissociation in the binding model.
FcRn association ratefcrn_kon_per_M_h806000001/M/hFcRn association rate governing molecular association in the binding model.
FcRn totalfcrn_total_M0.0000498MFcRn total coefficient used by the released system of model equations.
Fr FcRn recyclefr_fcrn_recycle0.715—Fr FcRn recycle coefficient used by the released system of model equations.
J adiposej_adipose_L_h0.000026862L/hJ adipose coefficient used by the released system of model equations.
J bonej_bone_L_h0.00003036L/hJ bone coefficient used by the released system of model equations.
J brainj_brain_L_h0.000023562L/hJ brain coefficient used by the released system of model equations.
J heartj_heart_L_h0.000072996L/hJ heart coefficient used by the released system of model equations.
J kidneyj_kidney_L_h0.000137016L/hJ kidney coefficient used by the released system of model equations.
J large intestinej_large_intestine_L_h0.000034584L/hJ large intestine coefficient used by the released system of model equations.
J liverj_liver_L_h0.000020526L/hJ liver coefficient used by the released system of model equations.
J lungj_lung_L_h0.000746262L/hJ lung coefficient used by the released system of model equations.
J musclej_muscle_L_h0.00017226L/hJ muscle coefficient used by the released system of model equations.
J otherj_other_L_h0.00002508L/hJ other coefficient used by the released system of model equations.
J pancreasj_pancreas_L_h0.000012474000000000001L/hJ pancreas coefficient used by the released system of model equations.
J skinj_skin_L_h0.000055638L/hJ skin coefficient used by the released system of model equations.
J small intestinej_small_intestine_L_h0.00011616L/hJ small intestine coefficient used by the released system of model equations.
J spleenj_spleen_L_h0.000016368L/hJ spleen coefficient used by the released system of model equations.
J thymusj_thymus_L_h0.000002376L/hJ thymus coefficient used by the released system of model equations.
Kloss adiposekloss_adipose_h0.00181/hKloss adipose coefficient used by the released system of model equations.
Kloss bloodkloss_blood_h0.00061/hKloss blood coefficient used by the released system of model equations.
Kloss bonekloss_bone_h0.00231/hKloss bone coefficient used by the released system of model equations.
Kloss brainkloss_brain_h01/hKloss brain coefficient used by the released system of model equations.
Kloss heartkloss_heart_h0.00041/hKloss heart coefficient used by the released system of model equations.
Kloss kidneykloss_kidney_h0.00181/hKloss kidney coefficient used by the released system of model equations.
Kloss large intestinekloss_large_intestine_h01/hKloss large intestine coefficient used by the released system of model equations.
Kloss liverkloss_liver_h0.00111/hKloss liver coefficient used by the released system of model equations.
Kloss lungkloss_lung_h0.00361/hKloss lung coefficient used by the released system of model equations.
Kloss musclekloss_muscle_h0.003351/hKloss muscle coefficient used by the released system of model equations.
Kloss otherkloss_other_h01/hKloss other coefficient used by the released system of model equations.
Kloss pancreaskloss_pancreas_h0.00121/hKloss pancreas coefficient used by the released system of model equations.
Kloss skinkloss_skin_h0.003841/hKloss skin coefficient used by the released system of model equations.
Kloss small intestinekloss_small_intestine_h01/hKloss small intestine coefficient used by the released system of model equations.
Kloss spleenkloss_spleen_h0.0021/hKloss spleen coefficient used by the released system of model equations.
Kloss thymuskloss_thymus_h01/hKloss thymus coefficient used by the released system of model equations.
Kprod baselinekprod_baseline_mol_copy_h5.64e-22mol/hKprod baseline governing production or formation in the modeled biological process.
Kprod gammakprod_gamma5—Kprod gamma governing production or formation in the modeled biological process.
Kprod high factorkprod_high_factor21.96—Kprod high factor governing production or formation in the modeled biological process.
Kprod km dose vgkprod_km_dose_vg1000000000—Kprod km dose vg governing production or formation in the modeled biological process.
Kprod maxkprod_max_mol_copy_h1.28e-20mol/hKprod max governing production or formation in the modeled biological process.
Ksecksec_h0.0221/hKsec coefficient used by the released system of model equations.
Lymph clearancelymph_clearance_L_h3.395L/hLymph clearance governing removal of modeled material from the relevant compartment.
Mab immune delaymab_immune_delay_h56hMab immune delay coefficient used by the released system of model equations.
Mab immune kmmab_immune_km_M0.000005MMab immune km coefficient used by the released system of model equations.
Mab immune maximum elimination ratemab_immune_vmax_h1.0581/hMab immune maximum elimination rate coefficient used by the released system of model equations.
Mab degradation ratemab_kdeg_h26.871/hMab degradation rate governing loss, degradation, or removal in the modeled biological process.
Q adiposeq_adipose_L_h0.013431L/hQ adipose governing exchange between model compartments.
Q boneq_bone_L_h0.01518L/hQ bone governing exchange between model compartments.
Q brainq_brain_L_h0.011781L/hQ brain governing exchange between model compartments.
Q csfq_csf_L_h0.0000198L/hQ csf governing exchange between model compartments.
Q heartq_heart_L_h0.036498L/hQ heart governing exchange between model compartments.
Q isfq_isf_L_h0.000009L/hQ isf governing exchange between model compartments.
Q kidneyq_kidney_L_h0.068508L/hQ kidney governing exchange between model compartments.
Q large intestineq_large_intestine_L_h0.017292L/hQ large intestine governing exchange between model compartments.
Q liverq_liver_L_h0.010263L/hQ liver governing exchange between model compartments.
Q lungq_lung_L_h0.373131L/hQ lung governing exchange between model compartments.
Q muscleq_muscle_L_h0.08613L/hQ muscle governing exchange between model compartments.
Q otherq_other_L_h0.01254L/hQ other governing exchange between model compartments.
Q pancreasq_pancreas_L_h0.006237L/hQ pancreas governing exchange between model compartments.
Q skinq_skin_L_h0.027819L/hQ skin governing exchange between model compartments.
Q small intestineq_small_intestine_L_h0.05808L/hQ small intestine governing exchange between model compartments.
Q spleenq_spleen_L_h0.008184L/hQ spleen governing exchange between model compartments.
Q thymusq_thymus_L_h0.001188L/hQ thymus governing exchange between model compartments.
Rtot adiposertot_adipose_copy_L16000000000000001/LRtot adipose coefficient used by the released system of model equations.
Rtot bloodrtot_blood_copy_L3300000000001/LRtot blood coefficient used by the released system of model equations.
Rtot bonertot_bone_copy_L660000000000001/LRtot bone coefficient used by the released system of model equations.
Rtot brainrtot_brain_copy_L100000000000001/LRtot brain coefficient used by the released system of model equations.
Rtot heartrtot_heart_copy_L3300000000000001/LRtot heart coefficient used by the released system of model equations.
Rtot kidneyrtot_kidney_copy_L660000000000001/LRtot kidney coefficient used by the released system of model equations.
Rtot large intestinertot_large_intestine_copy_L660000000000001/LUnassigned tissue mapped to the published low receptor tier.
Rtot liverrtot_liver_copy_L16000000000000001/LRtot liver coefficient used by the released system of model equations.
Rtot lungrtot_lung_copy_L3300000000000001/LRtot lung coefficient used by the released system of model equations.
Rtot musclertot_muscle_copy_L3300000000000001/LRtot muscle coefficient used by the released system of model equations.
Rtot otherrtot_other_copy_L660000000000001/LUnassigned tissue mapped to the published low receptor tier.
Rtot pancreasrtot_pancreas_copy_L660000000000001/LRtot pancreas coefficient used by the released system of model equations.
Rtot skinrtot_skin_copy_L660000000000001/LRtot skin coefficient used by the released system of model equations.
Rtot small intestinertot_small_intestine_copy_L660000000000001/LUnassigned tissue mapped to the published low receptor tier.
Rtot spleenrtot_spleen_copy_L3300000000000001/LRtot spleen coefficient used by the released system of model equations.
Rtot thymusrtot_thymus_copy_L660000000000001/LUnassigned tissue mapped to the published low receptor tier.
Sigma AAV adiposesigma_aav_adipose0.95—Sigma AAV adipose coefficient used by the released system of model equations.
Sigma AAV bonesigma_aav_bone0.85—Sigma AAV bone coefficient used by the released system of model equations.
Sigma AAV brainsigma_aav_brain0.95—Sigma AAV brain coefficient used by the released system of model equations.
Sigma AAV heartsigma_aav_heart0.9—Sigma AAV heart coefficient used by the released system of model equations.
Sigma AAV kidneysigma_aav_kidney0.9—Sigma AAV kidney coefficient used by the released system of model equations.
Sigma AAV large intestinesigma_aav_large_intestine0.95—Sigma AAV large intestine coefficient used by the released system of model equations.
Sigma AAV liversigma_aav_liver0.85—Sigma AAV liver coefficient used by the released system of model equations.
Sigma AAV lungsigma_aav_lung0.95—Sigma AAV lung coefficient used by the released system of model equations.
Sigma AAV lymphsigma_aav_lymph0.2—Sigma AAV lymph coefficient used by the released system of model equations.
Sigma AAV musclesigma_aav_muscle0.95—Sigma AAV muscle coefficient used by the released system of model equations.
Sigma AAV othersigma_aav_other0.95—Sigma AAV other coefficient used by the released system of model equations.
Sigma AAV pancreassigma_aav_pancreas0.9—Sigma AAV pancreas coefficient used by the released system of model equations.
Sigma AAV skinsigma_aav_skin0.95—Sigma AAV skin coefficient used by the released system of model equations.
Sigma AAV small intestinesigma_aav_small_intestine0.9—Sigma AAV small intestine coefficient used by the released system of model equations.
Sigma AAV spleensigma_aav_spleen0.85—Sigma AAV spleen coefficient used by the released system of model equations.
Sigma AAV thymussigma_aav_thymus0.9—Sigma AAV thymus coefficient used by the released system of model equations.
Sigma bbbsigma_bbb1—Sigma bbb coefficient used by the released system of model equations.
Sigma bcsfbsigma_bcsfb0.9973—Sigma bcsfb coefficient used by the released system of model equations.
Sigma brain isigma_brain_i0.2—Sigma brain i coefficient used by the released system of model equations.
Sigma mab adiposesigma_mab_adipose0.95—Sigma mab adipose coefficient used by the released system of model equations.
Sigma mab bonesigma_mab_bone0.85—Sigma mab bone coefficient used by the released system of model equations.
Sigma mab heartsigma_mab_heart0.9—Sigma mab heart coefficient used by the released system of model equations.
Sigma mab kidneysigma_mab_kidney0.9—Sigma mab kidney coefficient used by the released system of model equations.
Sigma mab large intestinesigma_mab_large_intestine0.95—Sigma mab large intestine coefficient used by the released system of model equations.
Sigma mab liversigma_mab_liver0.85—Sigma mab liver coefficient used by the released system of model equations.
Sigma mab lungsigma_mab_lung0.95—Sigma mab lung coefficient used by the released system of model equations.
Sigma mab lymphsigma_mab_lymph0.2—Sigma mab lymph coefficient used by the released system of model equations.
Sigma mab musclesigma_mab_muscle0.95—Sigma mab muscle coefficient used by the released system of model equations.
Sigma mab othersigma_mab_other0.95—Sigma mab other coefficient used by the released system of model equations.
Sigma mab pancreassigma_mab_pancreas0.9—Sigma mab pancreas coefficient used by the released system of model equations.
Sigma mab skinsigma_mab_skin0.95—Sigma mab skin coefficient used by the released system of model equations.
Sigma mab small intestinesigma_mab_small_intestine0.9—Sigma mab small intestine coefficient used by the released system of model equations.
Sigma mab spleensigma_mab_spleen0.85—Sigma mab spleen coefficient used by the released system of model equations.
Sigma mab thymussigma_mab_thymus0.9—Sigma mab thymus coefficient used by the released system of model equations.
Tau adiposetau_adipose_h30.323hTau adipose coefficient used by the released system of model equations.
Tau bonetau_bone_h30.323hTau bone coefficient used by the released system of model equations.
Tau braintau_brain_h30.323hTau brain coefficient used by the released system of model equations.
Tau early factortau_early_factor0.228—Tau early factor coefficient used by the released system of model equations.
Tau hearttau_heart_h69.591285hTau heart coefficient used by the released system of model equations.
Tau kidneytau_kidney_h30.323hTau kidney coefficient used by the released system of model equations.
Tau large intestinetau_large_intestine_h30.323hTau large intestine coefficient used by the released system of model equations.
Tau late factortau_late_factor2.295—Tau late factor coefficient used by the released system of model equations.
Tau livertau_liver_h6.913644000000001hTau liver coefficient used by the released system of model equations.
Tau lungtau_lung_h69.591285hTau lung coefficient used by the released system of model equations.
Tau mediumtau_medium_h30.323hTau medium coefficient used by the released system of model equations.
Tau muscletau_muscle_h69.591285hTau muscle coefficient used by the released system of model equations.
Tau othertau_other_h30.323hTau other coefficient used by the released system of model equations.
Tau pancreastau_pancreas_h30.323hTau pancreas coefficient used by the released system of model equations.
Tau skintau_skin_h30.323hTau skin coefficient used by the released system of model equations.
Tau small intestinetau_small_intestine_h30.323hTau small intestine coefficient used by the released system of model equations.
Tau spleentau_spleen_h69.591285hTau spleen coefficient used by the released system of model equations.
Tau thymustau_thymus_h30.323hTau thymus coefficient used by the released system of model equations.
V adipose bcv_adipose_bc_L0.000017838LMouse adipose blood-cell volume.
V adiposev_adipose_cell_L0.00159551LMouse adipose cellular volume.
V adipose cv ev_adipose_cv_e_L0.00011168570000000002LV adipose cv e coefficient used by the released system of model equations.
V adipose cv pv_adipose_cv_p_L0.0014838243000000002LV adipose cv p coefficient used by the released system of model equations.
V adipose ev_adipose_e_L0.00000991LMouse adipose endosomal volume.
V adipose iv_adipose_i_L0.00033694LMouse adipose interstitial volume.
V adipose totalv_adipose_total_L0.0019820000000000003LMouse adipose total volume.
V adipose vv_adipose_v_L0.000021802LMouse adipose vascular plasma volume.
V blood centralv_blood_central_L0.00077265LV blood central coefficient used by the released system of model equations.
V bone bcv_bone_bc_L0.000050832LMouse bone blood-cell volume.
V bonev_bone_cell_L0.002171656LMouse bone cellular volume.
V bone cv ev_bone_cv_e_L0.00015201592LV bone cv e coefficient used by the released system of model equations.
V bone cv pv_bone_cv_p_L0.00201964008LV bone cv p coefficient used by the released system of model equations.
V bone ev_bone_e_L0.00001412LMouse bone endosomal volume.
V bone iv_bone_i_L0.000525264LMouse bone interstitial volume.
V bone totalv_bone_total_L0.002824LMouse bone total volume.
V bone vv_bone_v_L0.000062128LMouse bone vascular plasma volume.
V brain bbbv_brain_bbb_L0.00000209LV brain bbb coefficient used by the released system of model equations.
V brain bcv_brain_bc_L0.00000873LMouse brain blood-cell volume.
V brain bcsfbv_brain_bcsfb_L3.38e-7LV brain bcsfb coefficient used by the released system of model equations.
V brainv_brain_cell_L0.000375875LMouse brain cellular volume.
V brain cmv_brain_cm_L0.0000011LV brain cm coefficient used by the released system of model equations.
V brain cv ev_brain_cv_e_L0.000026311250000000003LV brain cv e coefficient used by the released system of model equations.
V brain cv pv_brain_cv_p_L0.00034956375000000004LV brain cv p coefficient used by the released system of model equations.
V brain ev_brain_e_L0.000002425LMouse brain endosomal volume.
V brain iv_brain_i_L0.0000873LMouse brain interstitial volume.
V brain lvv_brain_lv_L0.000004LV brain lv coefficient used by the released system of model equations.
V brain sasv_brain_sas_L0.0000117LV brain sas coefficient used by the released system of model equations.
V brain tfvv_brain_tfv_L0.00000245LV brain tfv coefficient used by the released system of model equations.
V brain totalv_brain_total_L0.000485LMouse brain total volume.
V brain vv_brain_v_L0.00001067LMouse brain vascular plasma volume.
V heart bcv_heart_bc_L0.000004788LMouse heart blood-cell volume.
V heartv_heart_cell_L0.000118864LMouse heart cellular volume.
V heart cv ev_heart_cv_e_L0.000008320480000000001LV heart cv e coefficient used by the released system of model equations.
V heart cv pv_heart_cv_p_L0.00011054352000000001LV heart cv p coefficient used by the released system of model equations.
V heart ev_heart_e_L7.6e-7LMouse heart endosomal volume.
V heart iv_heart_i_L0.000021736LMouse heart interstitial volume.
V heart totalv_heart_total_L0.000152LMouse heart total volume.
V heart vv_heart_v_L0.000005852LMouse heart vascular plasma volume.
V kidney bcv_kidney_bc_L0.000023625LMouse kidney blood-cell volume.
V kidneyv_kidney_cell_L0.000391125LMouse kidney cellular volume.
V kidney cv ev_kidney_cv_e_L0.000027378750000000003LV kidney cv e coefficient used by the released system of model equations.
V kidney cv pv_kidney_cv_p_L0.00036374625LV kidney cv p coefficient used by the released system of model equations.
V kidney ev_kidney_e_L0.000002625LMouse kidney endosomal volume.
V kidney iv_kidney_i_L0.00007875LMouse kidney interstitial volume.
V kidney totalv_kidney_total_L0.000525LMouse kidney total volume.
V kidney vv_kidney_v_L0.000028875LMouse kidney vascular plasma volume.
V large intestine bcv_large_intestine_bc_L0.000004091175LMouse large_intestine blood-cell volume.
V large intestinev_large_intestine_cell_L0.000248292LMouse large_intestine cellular volume.
V large intestine cv ev_large_intestine_cv_e_L0.000017380440000000003LV large intestine cv e coefficient used by the released system of model equations.
V large intestine cv pv_large_intestine_cv_p_L0.00023091156000000002LV large intestine cv p coefficient used by the released system of model equations.
V large intestine ev_large_intestine_e_L0.0000015675LMouse large_intestine endosomal volume.
V large intestine iv_large_intestine_i_L0.000054549LMouse large_intestine interstitial volume.
V large intestine totalv_large_intestine_total_L0.0003135LMouse large_intestine total volume.
V large intestine vv_large_intestine_v_L0.000005000325LMouse large_intestine vascular plasma volume.
V liver bcv_liver_bc_L0.00013426875LMouse liver blood-cell volume.
V liverv_liver_cell_L0.001232405LMouse liver cellular volume.
V liver cv ev_liver_cv_e_L0.00008626835LV liver cv e coefficient used by the released system of model equations.
V liver cv pv_liver_cv_p_L0.00114613665LV liver cv p coefficient used by the released system of model equations.
V liver ev_liver_e_L0.000009625LMouse liver endosomal volume.
V liver iv_liver_i_L0.000384595163LMouse liver interstitial volume.
V liver totalv_liver_total_L0.001925000163LMouse liver total volume.
V liver vv_liver_v_L0.00016410625LMouse liver vascular plasma volume.
V lung bcv_lung_bc_L0.00002409962067LMouse lung blood-cell volume.
V lungv_lung_cell_L0.000111402LMouse lung cellular volume.
V lung cv ev_lung_cv_e_L0.00000779814LV lung cv e coefficient used by the released system of model equations.
V lung cv pv_lung_cv_p_L0.00010360386000000001LV lung cv p coefficient used by the released system of model equations.
V lung ev_lung_e_L0.0000010220365LMouse lung endosomal volume.
V lung iv_lung_i_L0.0000384285724LMouse lung interstitial volume.
V lung totalv_lung_total_L0.0002044073215LMouse lung total volume.
V lung vv_lung_v_L0.00002945509193LMouse lung vascular plasma volume.
V lymphv_lymph_L0.000113LV lymph coefficient used by the released system of model equations.
V muscle bcv_muscle_bc_L0.000203742LMouse muscle blood-cell volume.
V musclev_muscle_cell_L0.009338175LMouse muscle cellular volume.
V muscle cv ev_muscle_cv_e_L0.0006536722500000001LV muscle cv e coefficient used by the released system of model equations.
V muscle cv pv_muscle_cv_p_L0.008684502750000002LV muscle cv p coefficient used by the released system of model equations.
V muscle ev_muscle_e_L0.000056595LMouse muscle endosomal volume.
V muscle iv_muscle_i_L0.00147147LMouse muscle interstitial volume.
V muscle totalv_muscle_total_L0.011319000000000001LMouse muscle total volume.
V muscle vv_muscle_v_L0.000249018LMouse muscle vascular plasma volume.
V other bcv_other_bc_L0.0000159837LMouse other blood-cell volume.
V otherv_other_cell_L0.000347748LMouse other cellular volume.
V other cv ev_other_cv_e_L0.000024342360000000003LV other cv e coefficient used by the released system of model equations.
V other cv pv_other_cv_p_L0.00032340564LV other cv p coefficient used by the released system of model equations.
V other ev_other_e_L0.000002326591LMouse other endosomal volume.
V other iv_other_i_L0.0000797245183LMouse other interstitial volume.
V other totalv_other_total_L0.000465318418397LMouse other total volume.
V other vv_other_v_L0.000019535609097LMouse other vascular plasma volume.
V pancreas bcv_pancreas_bc_L0.000004365LMouse pancreas blood-cell volume.
V pancreasv_pancreas_cell_L0.000069937LMouse pancreas cellular volume.
V pancreas cv ev_pancreas_cv_e_L0.000004895590000000001LV pancreas cv e coefficient used by the released system of model equations.
V pancreas cv pv_pancreas_cv_p_L0.00006504141LV pancreas cv p coefficient used by the released system of model equations.
V pancreas ev_pancreas_e_L4.85e-7LMouse pancreas endosomal volume.
V pancreas iv_pancreas_i_L0.000016878LMouse pancreas interstitial volume.
V pancreas totalv_pancreas_total_L0.000097LMouse pancreas total volume.
V pancreas vv_pancreas_v_L0.000005335LMouse pancreas vascular plasma volume.
V plasmav_plasma_L0.00094435LV plasma coefficient used by the released system of model equations.
V skin bcv_skin_bc_L0.0001535814LMouse skin blood-cell volume.
V skinv_skin_cell_L0.002996343LMouse skin cellular volume.
V skin cv ev_skin_cv_e_L0.00020974401LV skin cv e coefficient used by the released system of model equations.
V skin cv pv_skin_cv_p_L0.00278659899LV skin cv p coefficient used by the released system of model equations.
V skin ev_skin_e_L0.000025095LMouse skin endosomal volume.
V skin iv_skin_i_L0.00165627LMouse skin interstitial volume.
V skin totalv_skin_total_L0.005019LMouse skin total volume.
V skin vv_skin_v_L0.0001877106LMouse skin vascular plasma volume.
V small intestine bcv_small_intestine_bc_L0.0000095004LMouse small_intestine blood-cell volume.
V small intestinev_small_intestine_cell_L0.000576576LMouse small_intestine cellular volume.
V small intestine cv ev_small_intestine_cv_e_L0.00004036032LV small intestine cv e coefficient used by the released system of model equations.
V small intestine cv pv_small_intestine_cv_p_L0.00053621568LV small intestine cv p coefficient used by the released system of model equations.
V small intestine ev_small_intestine_e_L0.00000364LMouse small_intestine endosomal volume.
V small intestine iv_small_intestine_i_L0.000126672LMouse small_intestine interstitial volume.
V small intestine totalv_small_intestine_total_L0.000728LMouse small_intestine total volume.
V small intestine vv_small_intestine_v_L0.0000116116LMouse small_intestine vascular plasma volume.
V spleen bcv_spleen_bc_L0.000012573LMouse spleen blood-cell volume.
V spleenv_spleen_cell_L0.000073025LMouse spleen cellular volume.
V spleen cv ev_spleen_cv_e_L0.000005111750000000001LV spleen cv e coefficient used by the released system of model equations.
V spleen cv pv_spleen_cv_p_L0.00006791325LV spleen cv p coefficient used by the released system of model equations.
V spleen ev_spleen_e_L6.35e-7LMouse spleen endosomal volume.
V spleen iv_spleen_i_L0.0000254LMouse spleen interstitial volume.
V spleen totalv_spleen_total_L0.000127LMouse spleen total volume.
V spleen vv_spleen_v_L0.000015367LMouse spleen vascular plasma volume.
V thymus bcv_thymus_bc_L4.05e-7LMouse thymus blood-cell volume.
V thymusv_thymus_cell_L0.000006525LMouse thymus cellular volume.
V thymus cv ev_thymus_cv_e_L4.5675000000000006e-7LV thymus cv e coefficient used by the released system of model equations.
V thymus cv pv_thymus_cv_p_L0.000006068250000000001LV thymus cv p coefficient used by the released system of model equations.
V thymus ev_thymus_e_L4.5e-8LMouse thymus endosomal volume.
V thymus iv_thymus_i_L0.00000153LMouse thymus interstitial volume.
V thymus totalv_thymus_total_L0.000009LMouse thymus total volume.
V thymus vv_thymus_v_L4.95e-7LMouse thymus vascular plasma volume.
Validation run noncevalidation_run_nonce0—Validation run nonce coefficient used by the released system of model equations.

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