SKB264 tumor-growth inhibition
Reference paper ↗A reduced tumor-growth model representing the balance between untreated tumor expansion and SKB264-associated tumor-cell killing.
- Therapeutic
- SKB264 (sacituzumab tirumotecan), anti-TROP2 humanized mAb shared with IMMU-132
- Modality
- Antibody–drug conjugate (ADC)
- Target
- TACSTD2, TROP2, EGP1
- Disease
- TROP2-positive preclinical tumor models
- Model type
- PKPD, ADC
Complete model workspace
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- Parameters
- 2
- States
- 1
- Equations
- 1
- Derived outputs
- 4
Explore this model
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Starting configuration
Default model behavior
Default model behavior
How does the modeled ADC killing rate change tumor-volume dynamics relative to intrinsic growth? Explore this biological starting configuration through Tumor volume, Net tumor growth rate.
Starting result
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Starting configuration
Time: 0–30 day; step 0.25
| Input | Default | Available range |
|---|---|---|
| Tumor growth rate | 0.04 1/day | 0.02–0.06 1/day |
| Tumor kill rate | 0 1/day | 0–1 1/day |
Expected readouts
Tumor volume (millimeter**3) · Net tumor growth rate
Adjustable model parameters
This public explorer exposes 2 curated parameters. Sign in to edit all 2 declared model parameters.
How the model represents the biology
A reduced tumor-growth model representing the balance between untreated tumor expansion and SKB264-associated tumor-cell killing.
Solid arrows show modeled movement or change; two-headed arrows show reversible exchange; dashed arrows show modulation without material transfer.
Model scope: ADC exposure, TROP2 binding, payload release, dose response, and a separate cell-death compartment are not represented; the public default kill coefficient is zero.
Modeled relationships (3)
- Intrinsic growth rate → Net growth balance: positive drive (modulation)
- Kill coefficient → Net growth balance: negative drive (modulation)
- Net growth balance → Tumor volume: changes V (modulation)
Modeled relationships: Intrinsic growth rate to Net growth balance: positive drive (modulation); Kill coefficient to Net growth balance: negative drive (modulation); Net growth balance to Tumor volume: changes V (modulation).
Primary readouts: Tumor volume; Net tumor-growth rate.
Related models
Research use only — not for patient-specific prediction or dosing advice.
