Naratuximab emtansine dose and plasma exposure
A reduced dose–exposure model for the CD37-directed ADC naratuximab emtansine, representing plasma decline and cumulative exposure across dose levels.
- Therapeutic
- Naratuximab emtansine, Naratuximab / K7153A
- Target
- CD37
- Disease
- Relapsed or refractory B-cell non-Hodgkin lymphoma
Biological model
A reduced dose–exposure model for the CD37-directed ADC naratuximab emtansine, representing plasma decline and cumulative exposure across dose levels.
Model details
A reduced dose–exposure model for the CD37-directed ADC naratuximab emtansine, representing plasma decline and cumulative exposure across dose levels.
Modeled states
- auc h ug mLh*ug/mL
Modeled dynamic state for auc h ug ml.
- elapsed hh
Modeled dynamic state for elapsed h.
- plasma imgn529 ug mLug/mL
Modeled dynamic state for plasma imgn529 ug ml.
Key readouts
- Plasma naratuximab emtansineug/mL
Model-derived readout for plasma naratuximab emtansine.
- Cumulative ADC exposureh*ug/mL
Model-derived readout for cumulative adc exposure.
- Peak ADC concentrationunknown
Model-derived readout for peak adc concentration.
- Extrapolated total exposureunknown
Model-derived readout for extrapolated total exposure.
- calibrated cl linear per kgunknown
Model-derived readout for calibrated cl linear per kg.
Explore this model
Choose a starting point to view its result. Adjust key model inputs when you want to explore a different outcome.
0.1 mg/kg exponential
How does dose level change naratuximab emtansine plasma concentration and cumulative exposure? Explore this biological starting configuration through Plasma naratuximab emtansine, Cumulative ADC exposure, Peak ADC concentration, Extrapolated total exposure. This is a mechanistic product exploration, not a paper-result reproduction.
Questions to explore
- How does dose level change naratuximab emtansine plasma concentration and cumulative exposure?
Starting result
This result reflects the starting settings. Run your changes to update it.
Model inputs
Five scientist-facing controls at most.
Compare a parameter
How does one model input change the response?
How does dose level change naratuximab emtansine plasma concentration and cumulative exposure?
selected dose mg kg
Model parameter controlling selected dose mg kg.
Exploratory range around the default value.
5 evenly spaced values in mg/kg. Other model inputs and the simulation window stay fixed.
Interpret with care
- Interpret trajectories as deterministic model behavior, not as a patient-specific prediction or dosing recommendation.
- Paper-result and exact-anchor checks remain in the private validation lane and are not part of this public scenario.
Review the server-confirmed fixed price before starting the comparison.
Comparative response
End-of-window response across the selected parameter values.
Choose an exploratory range around the default, review the fixed price, and run the comparison.
