Membrane Ternary Binding
A generic dynamic model for exploring how a bifunctional ligand binds two finite membrane-site classes, forms a ternary bridge through either binary intermediate, and can enter a high-ligand hook regime.
- Therapeutic
- generic bifunctional membrane ligand
- Modality
- Other biologic or therapeutic modality
- Target
- configurable left membrane site, configurable right membrane site
- Disease
- Mechanism-agnostic membrane-bridging research
- Model type
- QSP
Complete model workspace
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- Parameters
- 9
- States
- 5
- Equations
- 5
- Derived outputs
- 9
Explore this model
Choose a starting point to view its result. Adjust key model inputs when you want to explore a different outcome.
Low ligand
Tests the ligand-limited side of the ternary-bridge response.
Starting result
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Starting configuration
Time: 0–24 hour; step 0.25
| Input | Default | Available range |
|---|---|---|
| Free ligand reservoir | 0.08 nM | 0.04–0.12 nM |
| Left site association | 0.08 1/(nM*h) | 0.04–0.12 1/(nM*h) |
| Left site dissociation | 0.4 1/h | 0.2–0.6 1/h |
| Right site association | 0.04 1/(nM*h) | 0.02–0.06 1/(nM*h) |
| Right site dissociation | 0.8 1/h | 0.4–1.2 1/h |
Expected readouts
Total binary complex (nM) · Ternary bridge (nM) · Left sites in ternary bridges (percent) · Right sites in ternary bridges (percent)
Adjustable model parameters
This public explorer exposes 5 curated parameters. Sign in to edit all 9 declared model parameters.
More key parameters (1)
How the model represents the biology
Explores how an open ligand reservoir, asymmetric binary affinities, membrane site densities, and two crosslink routes produce binary occupancy, ternary bridging, and a high-ligand hook regime.
Related models
Research use only — not for patient-specific prediction or dosing advice.
