Atezolizumab PK: standard and loading schedules
Compare serum atezolizumab exposure across the released dosing schedules, with fixed patient covariates and time-varying clearance.
A comparison of pharmacometric software programs for atezolizumab population pharmacokinetic simulation ↗European Journal of Clinical Pharmacology
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MODEL IN MOTION 18 sec
How do the fixed standard and loading schedules differ during extended dosing?
Standard 1200 mg every 3 weeks
Fixed atezolizumab latent-PK context with explicit central mg input and source-unit observation grid.
0–147 day
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Biology
Fixed-covariate two-compartment atezolizumab PK with changing clearance, explicit IV inputs, concentration exposure and integrated drug accounting.
Model details
29 parameters · 5 states · 5 equations · 39 derived outputs
Classification & API access
- Therapeutic
- Atezolizumab
- Modality
- Monoclonal antibody
- Target
- PD-L1 / CD274
- Disease / scope
- Oncology dosing-regimen simulation
| Parameter | Default | Unit | Description |
|---|---|---|---|
Serum albuminalbumin_g_l | 40 | g/L | Baseline serum albumin used to scale clearance and central distribution volume. |
ATAG status indicatoratag_flag | 0 | — | Binary source covariate. The supplied metadata does not define ATAG; confirm its meaning before changing this value. |
Baseline tumor sizebaseline_tumor_size_mm | 63 | mm | Baseline tumor size used in the clearance covariate relationship. |
Body weightbody_weight_kg | 77 | kg | Body weight used for body-size scaling in the model. |
Eta clearanceeta_cl | 0 | — | Fixed log-scale individual coordinate; supplied single-coordinate sensitivity is +0.263. No random draw occurs. |
Eta Imaxeta_imax | 0 | — | Fixed log-scale individual coordinate; supplied single-coordinate sensitivity is +0.897. No random draw occurs. |
Eta central distribution volumeeta_vc | 0 | — | Fixed log-scale individual coordinate; supplied single-coordinate sensitivity is +0.172. No random draw occurs. |
Eta peripheral distribution volumeeta_vp | 0 | — | Fixed log-scale individual coordinate; supplied single-coordinate sensitivity is +0.352. No random draw occurs. |
Female sex indicatorfemale_flag | 0 | — | Binary sex covariate used to scale central and peripheral distribution volumes. |
Reference serum albuminreference_albumin_g_l | 40 | g/L | Reference albumin used to normalize the albumin covariate. |
Reference tumor sizereference_tumor_size_mm | 63 | mm | Reference tumor size used to normalize the clearance covariate. |
Reference weightreference_weight_kg | 77 | kg | Reference weight coefficient used by the released system of model equations. |
Additive observation standard deviationresidual_add_sd_ug_ml | 18.1 | µg/mL | Additive observation-error standard deviation retained from the source diagnostic. No observation noise is sampled. |
Proportional observation standard deviationresidual_prop_sd | 0.034 | — | Proportional observation-error standard deviation retained from the source diagnostic. No observation noise is sampled. |
Albumin exponent on clearancetheta_alb_cl | -0.901 | — | Exponent applied to normalized serum albumin in the baseline clearance equation. |
Albumin exponent on central volumetheta_alb_vc | -0.345 | — | Exponent applied to normalized serum albumin in the central distribution volume equation. |
ATAG multiplier on clearancetheta_atag_cl | 1.158 | — | Clearance multiplier raised to the binary ATAG indicator. Its clinical definition is not supplied in the released metadata. |
Tumor-size exponent on clearancetheta_bts_cl | 0.116 | — | Exponent applied to normalized baseline tumor size in the baseline clearance equation. |
Body-weight exponent on clearancetheta_bw_cl | 0.668 | — | Exponent applied to normalized body weight in the baseline clearance equation. |
Body-weight exponent on central volumetheta_bw_vc | 0.533 | — | Exponent applied to normalized body weight in the central distribution volume equation. |
Typical clearancetheta_cl_l_day | 0.23 | L/day | Typical clearance governing removal of modeled material from the relevant compartment. |
Clearance time-course shapetheta_gamma | 2.67 | — | Hill exponent controlling how the time-dependent change in clearance approaches its limit. |
Maximum log change in clearancetheta_imax | -0.193 | — | Limiting log change in clearance over time: clearance equals baseline clearance multiplied by exp(individual Imax × time fraction). This is a PK parameter. |
Typical intercompartmental clearancetheta_q_l_day | 0.603 | L/day | Typical intercompartmental clearance governing exchange between model compartments. |
Female sex multiplier on central volumetheta_sex_vc | 0.896 | — | Central volume multiplier applied when the female sex indicator is one. |
Female sex multiplier on peripheral volumetheta_sex_vp | 0.707 | — | Peripheral volume multiplier applied when the female sex indicator is one. |
Typical time to half-maximal changetheta_t50_day | 62.8 | day | Typical time to half-maximal change coefficient used by the released system of model equations. |
Typical central distribution volumetheta_vc_l | 3.25 | L | Typical central distribution volume used to convert modeled amount to concentration in the relevant compartment. |
Typical peripheral distribution volumetheta_vp_l | 2.88 | L | Typical peripheral distribution volume used to convert modeled amount to concentration in the relevant compartment. |
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