Secukinumab fixed PK and response-coordinate reference

Fixed marginal-mean profile 1, 300 mg, 4-week maintenance

Conditional zero-drug initialization, explicit SC calendar and fixed supplementary marginal-mean inputs. Unconstrained response coordinate, not a patient forecast or posterior simulation.

Readouts

Central concentration · mg/L

Fixed conditional model quantity in declared units.

Unconstrained PASI scale response coordinate · dimensionless

Unconstrained PASI-scale model coordinate; may be negative and is not a clinical score or probability.

AUC conc · mg*day/L

Fixed conditional model quantity in declared units.

Integrated systemic linear elimination · mg

Fixed conditional model quantity in declared units.

Subcutaneous amount not reaching systemic circulation · mg

Fixed conditional model quantity in declared units.

Study purpose

• How do the model's key biological readouts change under fixed marginal-mean profile 1, 300 mg, 4-week maintenance?

Assumptions

• Fixed marginal-mean profiles and declared calendars, not original patient forecasts, joint posterior simulations, population estimation or clinical dose selection.
• The unconstrained PASI-scale response coordinate may be negative. It is not a physical PASI score, a transformed latent scale or a probability.
• SLP is fixed to zero, tolerance progression and remission rates are equal, and all three tolerance coordinates start at one; they remain one throughout these histories.
• All inputs are fixed within each history. No body-weight, race, adherence, prior-exposure or patient-update model is inferred.
• The source marginal means/SD and population estimates are separate read-only reference information. No independent-marginal draws are treated as a joint posterior.
• Source time is days. AUC retains mg*day/L even if the display clock is changed.