Target-Gated Cargo QSP
Mechanistic QSP model for an intravenously dosed biologic designed to remain closed systemically and open after engaging a tumor-enriched gate. It connects three-compartment disposition, reversible cargo accessibility, tumor retention, and central-versus-tumor receptor occupancy using transparent UBI-authored equations and synthetic exploratory assumptions.
- Therapeutic
- generic target-gated cargo
- Target
- configurable tumor gate target, configurable cargo receptor
- Disease
- Solid tumors with an accessible tumor-enriched gate target
- Model type
- QSP, TMDD
Complete model workspace
The public explorer presents a concise set of curated controls and readouts. Sign in to edit every declared parameter and run the complete released model.
- Parameters
- 21
- States
- 11
- Equations
- 11
- Derived outputs
- 19
Explore this model
Choose a starting point to view its result. Adjust key model inputs when you want to explore a different outcome.
Balanced gate, 30 nmol IV
Nominal synthetic probe intended to produce low-to-moderate systemic cargo-receptor occupancy and substantially higher tumor occupancy.
Starting result
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Starting configuration
Time: 0–336 hour; step 6
| Input | Default | Available range |
|---|---|---|
| Background opening rate | 0.004 1/h | 0.002–0.006 1/h |
| Accessible tumor gate target capacity | 0.15 nmol | 0.075–0.225 nmol |
| Open construct gate dissociation | 0.03 1/h | 0.015–0.045 1/h |
| Cargo receptor association | 0.4 1/(nM*h) | 0.2–0.6 1/(nM*h) |
| Central tumor exchange clearance | 2.00e-5 L/h | 1.00e-5–3.00e-5 L/h |
Expected readouts
Systemic cargo receptor occupancy (%) · Tumor cargo receptor occupancy (%) · Tumor gate target occupancy (%) · Total modeled construct (nmol)
Adjustable model parameters
This public explorer exposes 5 curated parameters. Sign in to edit all 21 declared model parameters.
More key parameters (1)
How the model represents the biology
Explores how systemic closure, tumor-gate abundance and affinity, gate-assisted opening, tumor retention, cargo-receptor affinity, and dose combine to create a local-versus-systemic receptor-occupancy window.
Research use only — not for patient-specific prediction or dosing advice.
