Whole-body AAV–anti-TargetX rat brain QSP
Mechanistic rat QSP coupling whole-body AAV biodistribution, intracellular transduction, transgene-derived anti-TargetX mAb, FcRn-aware protein PBPK, TargetX binding, and detailed brain/CSF transport across 725 explicit scalar states.
QSP model for AAV-mediated antibody delivery in rat brain ↗Journal of Pharmacokinetics and Pharmacodynamics
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MODEL IN MOTION 18 sec
How do IV and cisterna-magna AAV delivery change brain antibody exposure?
Mid-dose AAV9 delivery — 1E12 Vg ICM
Mid-dose AAV9 delivery into cisterna-magna CSF.
-1,000–1,344 hour
Inputs changed since the displayed result. Run to update the comparison.
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Biology
Route-specific AAV enters whole-body and brain disposition, undergoes receptor-mediated cellular uptake and nuclear delivery, and drives delayed transgene expression. Secreted antibody distributes across plasma, tissues, brain, and cerebrospinal fluid, where it binds local free TargetX reversibly. Direct intravenous antibody and TargetX calibration inputs bypass transduction.
Solid arrows show modeled movement or change; two-headed arrows show reversible exchange; dashed arrows show modulation without material transfer.
Model scope: This overview intentionally does not reproduce the validated 725-state topology. Blood-cell AAV modules do not produce transgene-derived antibody; direct IV mAb and TargetX are calibration branches; TargetX is anonymized; and disease efficacy or toxicity is not represented.
Modeled relationships (10)
- AAV, mAb, or TargetX input → AAV disposition: IV / ICM / IST AAV (flow)
- AAV disposition → Cell uptake and nuclear vector: uptake and nuclear delivery (flow)
- Cell uptake and nuclear vector → Delayed transgene expression: three expression delays (production)
- Delayed transgene expression → Anti-TargetX mAb disposition: mAb secretion (production)
- AAV, mAb, or TargetX input → Anti-TargetX mAb disposition: direct IV mAb calibration (flow)
- AAV, mAb, or TargetX input → Free TargetX pools: direct IV target calibration (flow)
- Anti-TargetX mAb disposition → Local mAb–TargetX complexes: local kon binding (production)
- Free TargetX pools → Local mAb–TargetX complexes: binding consumes target (flow)
- Local mAb–TargetX complexes → Anti-TargetX mAb disposition: koff returns mAb (flow)
- Local mAb–TargetX complexes → Free TargetX pools: koff returns TargetX (flow)
Modeled relationships: AAV, mAb, or TargetX input to AAV disposition: IV / ICM / IST AAV (flow); AAV disposition to Cell uptake and nuclear vector: uptake and nuclear delivery (flow); Cell uptake and nuclear vector to Delayed transgene expression: three expression delays (production); Delayed transgene expression to Anti-TargetX mAb disposition: mAb secretion (production); AAV, mAb, or TargetX input to Anti-TargetX mAb disposition: direct IV mAb calibration (flow); AAV, mAb, or TargetX input to Free TargetX pools: direct IV target calibration (flow); Anti-TargetX mAb disposition to Local mAb–TargetX complexes: local kon binding (production); Free TargetX pools to Local mAb–TargetX complexes: binding consumes target (flow); Local mAb–TargetX complexes to Anti-TargetX mAb disposition: koff returns mAb (flow); Local mAb–TargetX complexes to Free TargetX pools: koff returns TargetX (flow).
Primary readouts: Plasma, brain and CSF antibody; Free TargetX; mAb–TargetX complex; Nuclear vector and expression.
Model details
325 parameters · 725 states · 725 equations · 27 derived outputs
Classification & API access
- Therapeutic
- AAV9/AAV5-encoded anti-TargetX monoclonal antibody
- Modality
- Gene-delivered antibody
- Target
- TargetX (anonymized paper target)
- Disease / scope
- Preclinical CNS antibody delivery (not disease-specific)
| Parameter | Default | Unit | Description |
|---|---|---|---|
AAV tissue-distribution coefficientaav_kd_copy_L | 72000000000000 | 1/L | AAV tissue-distribution coefficient describing equilibrium binding affinity in the modeled interaction. |
AAV degradation rateaav_kdeg_h | 1.007 | 1/h | AAV degradation rate governing loss, degradation, or removal in the modeled biological process. |
AAV kintaav_kint_h | 1 | 1/h | AAV kint coefficient used by the released system of model equations. |
AAV knucaav_knuc_h | 0.1 | 1/h | AAV knuc coefficient used by the released system of model equations. |
AAV dissociation rateaav_koff_h | 0.095 | 1/h | AAV dissociation rate governing molecular dissociation in the binding model. |
AAV association rateaav_kon_L_copy_h | 1.3194444444444445e-15 | L/h | AAV association rate governing molecular association in the binding model. |
AAV krecaav_krec_h | 1 | 1/h | AAV krec coefficient used by the released system of model equations. |
AAV ktransaav_ktrans_h | 1 | 1/h | AAV ktrans coefficient used by the released system of model equations. |
AAV loss stopaav_loss_stop_h | 504 | h | AAV loss stop coefficient used by the released system of model equations. |
Bcq adiposebcq_adipose_L_h | 0.184 | L/h | Bcq adipose coefficient used by the released system of model equations. |
Bcq bonebcq_bone_L_h | 0.0502 | L/h | Bcq bone coefficient used by the released system of model equations. |
Bcq brainbcq_brain_L_h | 0.0535 | L/h | Bcq brain coefficient used by the released system of model equations. |
Bcq heartbcq_heart_L_h | 0.124 | L/h | Bcq heart coefficient used by the released system of model equations. |
Bcq kidneybcq_kidney_L_h | 0.298 | L/h | Bcq kidney coefficient used by the released system of model equations. |
Bcq large intestinebcq_large_intestine_L_h | 0.13 | L/h | Bcq large intestine coefficient used by the released system of model equations. |
Bcq liverbcq_liver_L_h | 0.0173 | L/h | Bcq liver coefficient used by the released system of model equations. |
Bcq lungbcq_lung_L_h | 2.3954 | L/h | Pulmonary blood-cell outflow normalized to the sum of modeled tissue inflows. |
Bcq lung published roundedbcq_lung_published_rounded_L_h | 2.409 | L/h | Bcq lung published rounded coefficient used by the released system of model equations. |
Bcq musclebcq_muscle_L_h | 0.757 | L/h | Bcq muscle coefficient used by the released system of model equations. |
Bcq otherbcq_other_L_h | 0.0856 | L/h | Bcq other coefficient used by the released system of model equations. |
Bcq pancreasbcq_pancreas_L_h | 0.0518 | L/h | Bcq pancreas coefficient used by the released system of model equations. |
Bcq skinbcq_skin_L_h | 0.163 | L/h | Bcq skin coefficient used by the released system of model equations. |
Bcq small intestinebcq_small_intestine_L_h | 0.325 | L/h | Bcq small intestine coefficient used by the released system of model equations. |
Bcq spleenbcq_spleen_L_h | 0.146 | L/h | Bcq spleen coefficient used by the released system of model equations. |
Bcq thymusbcq_thymus_L_h | 0.01 | L/h | Bcq thymus coefficient used by the released system of model equations. |
Brain bbb fractionbrain_bbb_fraction | 0.8611 | — | Brain bbb fraction represented as a dimensionless fraction in the released equations. |
Brain lv fractionbrain_lv_fraction | 0.5 | — | Brain lv fraction represented as a dimensionless fraction in the released equations. |
Clearance renal complexcl_renal_complex_L_h | 0 | L/h | Clearance renal complex governing removal of modeled material from the relevant compartment. |
Clearance renal mabcl_renal_mab_L_h | 0 | L/h | Clearance renal mab governing removal of modeled material from the relevant compartment. |
Clearance renal targetcl_renal_target_L_h | 0.1 | L/h | Clearance renal target governing removal of modeled material from the relevant compartment. |
Clupclup_L_h_L | 0.1537 | L/h/L | Clup coefficient used by the released system of model equations. |
Clup brainclup_brain_L_h_L | 0.0305 | L/h/L | Clup brain coefficient used by the released system of model equations. |
Clup brainclup_brain_cell_L_h | 0.000019 | L/h | Clup brain coefficient used by the released system of model equations. |
Diff complexdiff_complex | 0 | — | Diff complex coefficient used by the released system of model equations. |
Diff mabdiff_mab | 0 | — | Diff mab coefficient used by the released system of model equations. |
Diff targetdiff_target | 24.75 | — | Diff target coefficient used by the released system of model equations. |
Dose scale AAV cmdose_scale_aav_cm_per_L | 58823.529411764706 | 1/L | Dose scale AAV cm defining the modeled treatment input for the explored scenario. |
Dose scale AAV isfdose_scale_aav_isf_per_L | 2439.0243902439024 | 1/L | Dose scale AAV isf defining the modeled treatment input for the explored scenario. |
Dose scale AAV plasmadose_scale_aav_plasma_per_L | 869.5652173913044 | 1/L | Dose scale AAV plasma defining the modeled treatment input for the explored scenario. |
Dose scale mab plasmadose_scale_mab_plasma_per_L | 869.5652173913044 | 1/L | Dose scale mab plasma defining the modeled treatment input for the explored scenario. |
Dose scale target plasmadose_scale_target_plasma_per_L | 869.5652173913044 | 1/L | Dose scale target plasma defining the modeled treatment input for the explored scenario. |
FcRn dissociation rate complexfcrn_koff_complex_h | 144 | 1/h | FcRn dissociation rate complex governing molecular dissociation in the binding model. |
FcRn dissociation rate mabfcrn_koff_mab_h | 144 | 1/h | FcRn dissociation rate mab governing molecular dissociation in the binding model. |
FcRn dissociation rate targetfcrn_koff_target_h | 144 | 1/h | FcRn dissociation rate target governing molecular dissociation in the binding model. |
FcRn association rate complexfcrn_kon_complex_per_M_h | 800000000 | 1/M/h | FcRn association rate complex governing molecular association in the binding model. |
FcRn association rate mabfcrn_kon_mab_per_M_h | 800000000 | 1/M/h | FcRn association rate mab governing molecular association in the binding model. |
FcRn association rate targetfcrn_kon_target_per_M_h | 0 | 1/M/h | FcRn association rate target governing molecular association in the binding model. |
FcRn totalfcrn_total_M | 0.0000498 | M | FcRn total coefficient used by the released system of model equations. |
Fr AAV pv to lymphfr_aav_pv_to_lymph | 0 | — | Fr AAV pv to lymph coefficient used by the released system of model equations. |
Fr FcRn recyclefr_fcrn_recycle | 0.715 | — | Fr FcRn recycle coefficient used by the released system of model equations. |
J adiposej_adipose_L_h | 0.000448 | L/h | J adipose coefficient used by the released system of model equations. |
J bonej_bone_L_h | 0.0001228 | L/h | J bone coefficient used by the released system of model equations. |
J heartj_heart_L_h | 0.000302 | L/h | J heart coefficient used by the released system of model equations. |
J kidneyj_kidney_L_h | 0.00073 | L/h | J kidney coefficient used by the released system of model equations. |
J large intestinej_large_intestine_L_h | 0.000316 | L/h | J large intestine coefficient used by the released system of model equations. |
J liverj_liver_L_h | 0.0016358064 | L/h | J liver coefficient used by the released system of model equations. |
J lungj_lung_L_h | 0.0058568 | L/h | J lung coefficient used by the released system of model equations. |
J musclej_muscle_L_h | 0.00185 | L/h | J muscle coefficient used by the released system of model equations. |
J otherj_other_L_h | 0.00021 | L/h | J other coefficient used by the released system of model equations. |
J pancreasj_pancreas_L_h | 0.0001268 | L/h | J pancreas coefficient used by the released system of model equations. |
J skinj_skin_L_h | 0.0004 | L/h | J skin coefficient used by the released system of model equations. |
J small intestinej_small_intestine_L_h | 0.000796 | L/h | J small intestine coefficient used by the released system of model equations. |
J spleenj_spleen_L_h | 0.000358 | L/h | J spleen coefficient used by the released system of model equations. |
J thymusj_thymus_L_h | 0.0000244 | L/h | J thymus coefficient used by the released system of model equations. |
Kloss adiposekloss_adipose_h | 0.0046 | 1/h | Kloss adipose coefficient used by the released system of model equations. |
Kloss bloodkloss_blood_h | 0.00087 | 1/h | Kloss blood coefficient used by the released system of model equations. |
Kloss bonekloss_bone_h | 0.00397 | 1/h | Kloss bone coefficient used by the released system of model equations. |
Kloss brainkloss_brain_h | 0 | 1/h | Kloss brain coefficient used by the released system of model equations. |
Kloss heartkloss_heart_h | 0.00091 | 1/h | Kloss heart coefficient used by the released system of model equations. |
Kloss kidneykloss_kidney_h | 0.0028 | 1/h | Kloss kidney coefficient used by the released system of model equations. |
Kloss large intestinekloss_large_intestine_h | 0 | 1/h | Kloss large intestine coefficient used by the released system of model equations. |
Kloss liverkloss_liver_h | 0.0027 | 1/h | Kloss liver coefficient used by the released system of model equations. |
Kloss lungkloss_lung_h | 0.00495 | 1/h | Kloss lung coefficient used by the released system of model equations. |
Kloss musclekloss_muscle_h | 0.00335 | 1/h | Kloss muscle coefficient used by the released system of model equations. |
Kloss otherkloss_other_h | 0 | 1/h | Kloss other coefficient used by the released system of model equations. |
Kloss pancreaskloss_pancreas_h | 0.0028 | 1/h | Kloss pancreas coefficient used by the released system of model equations. |
Kloss skinkloss_skin_h | 0.00384 | 1/h | Kloss skin coefficient used by the released system of model equations. |
Kloss small intestinekloss_small_intestine_h | 0 | 1/h | Kloss small intestine coefficient used by the released system of model equations. |
Kloss spleenkloss_spleen_h | 0.0069 | 1/h | Kloss spleen coefficient used by the released system of model equations. |
Kloss thymuskloss_thymus_h | 0 | 1/h | Kloss thymus coefficient used by the released system of model equations. |
Kprod adiposekprod_adipose_mol_copy_h | 1.177e-22 | mol/h | Kprod adipose governing production or formation in the modeled biological process. |
Kprod bonekprod_bone_mol_copy_h | 1.177e-22 | mol/h | Kprod bone governing production or formation in the modeled biological process. |
Kprod brainkprod_brain_mol_copy_h | 1.177e-22 | mol/h | Kprod brain governing production or formation in the modeled biological process. |
Kprod heartkprod_heart_mol_copy_h | 1.7402e-21 | mol/h | Kprod heart governing production or formation in the modeled biological process. |
Kprod kidneykprod_kidney_mol_copy_h | 1.7402e-21 | mol/h | Kprod kidney governing production or formation in the modeled biological process. |
Kprod large intestinekprod_large_intestine_mol_copy_h | 1.177e-22 | mol/h | Kprod large intestine governing production or formation in the modeled biological process. |
Kprod liverkprod_liver_mol_copy_h | 1.177e-22 | mol/h | Kprod liver governing production or formation in the modeled biological process. |
Kprod lungkprod_lung_mol_copy_h | 1.7402e-21 | mol/h | Kprod lung governing production or formation in the modeled biological process. |
Kprod mouse highkprod_mouse_high_mol_copy_h | 1.582e-20 | mol/h | Kprod mouse high governing production or formation in the modeled biological process. |
Kprod mouse otherkprod_mouse_other_mol_copy_h | 1.07e-21 | mol/h | Kprod mouse other governing production or formation in the modeled biological process. |
Kprod musclekprod_muscle_mol_copy_h | 1.177e-22 | mol/h | Kprod muscle governing production or formation in the modeled biological process. |
Kprod otherkprod_other_mol_copy_h | 1.177e-22 | mol/h | Kprod other governing production or formation in the modeled biological process. |
Kprod pancreaskprod_pancreas_mol_copy_h | 1.177e-22 | mol/h | Kprod pancreas governing production or formation in the modeled biological process. |
Rat production-rate scale factorkprod_rat_scale | 0.11 | — | Rat production-rate scale factor governing production or formation in the modeled biological process. |
Kprod skinkprod_skin_mol_copy_h | 1.177e-22 | mol/h | Kprod skin governing production or formation in the modeled biological process. |
Kprod small intestinekprod_small_intestine_mol_copy_h | 1.177e-22 | mol/h | Kprod small intestine governing production or formation in the modeled biological process. |
Kprod spleenkprod_spleen_mol_copy_h | 1.7402e-21 | mol/h | Kprod spleen governing production or formation in the modeled biological process. |
Kprod thymuskprod_thymus_mol_copy_h | 1.177e-22 | mol/h | Kprod thymus governing production or formation in the modeled biological process. |
Ksecksec_h | 0.022 | 1/h | Ksec coefficient used by the released system of model equations. |
Ksyn target isfksyn_target_isf_M_h | 2.2e-12 | M/h | Ksyn target isf governing production or formation in the modeled biological process. |
Ksyn target lvksyn_target_lv_M_h | 1.6e-10 | M/h | Ksyn target lv governing production or formation in the modeled biological process. |
Ksyn target plasmaksyn_target_plasma_M_h | 1.2e-8 | M/h | Ksyn target plasma governing production or formation in the modeled biological process. |
Lymph clearancelymph_clearance_L_h | 3.395 | L/h | Lymph clearance governing removal of modeled material from the relevant compartment. |
Lymph flow fractionlymph_flow_fraction | 0.002 | — | Lymph flow fraction represented as a dimensionless fraction in the released equations. |
Protein degradation rateprotein_kdeg_h | 30.4863 | 1/h | Protein degradation rate governing loss, degradation, or removal in the modeled biological process. |
Ps AAVps_aav_L_h | 2.62e-7 | L/h | Ps AAV coefficient used by the released system of model equations. |
Ps complexps_complex_L_h | 2.62e-7 | L/h | Ps complex coefficient used by the released system of model equations. |
Antibody permeability–surface area coefficientps_mab_L_h | 2.62e-7 | L/h | Antibody permeability–surface area coefficient coefficient used by the released system of model equations. |
Ps targetps_target_L_h | 0.000005667 | L/h | Ps target coefficient used by the released system of model equations. |
Q adiposeq_adipose_L_h | 0.224 | L/h | Q adipose governing exchange between model compartments. |
Q boneq_bone_L_h | 0.061399999999999996 | L/h | Q bone governing exchange between model compartments. |
Q brainq_brain_L_h | 0.0653 | L/h | Q brain governing exchange between model compartments. |
Q csfq_csf_L_h | 0.000132 | L/h | Q csf governing exchange between model compartments. |
Q csf oscq_csf_osc_L_h | 0.0000504 | L/h | Q csf osc governing exchange between model compartments. |
Q heartq_heart_L_h | 0.151 | L/h | Q heart governing exchange between model compartments. |
Q isfq_isf_L_h | 0.000019 | L/h | Q isf governing exchange between model compartments. |
Q kidneyq_kidney_L_h | 0.365 | L/h | Q kidney governing exchange between model compartments. |
Q large intestineq_large_intestine_L_h | 0.158 | L/h | Q large intestine governing exchange between model compartments. |
Q liverq_liver_L_h | 0.0211 | L/h | Q liver governing exchange between model compartments. |
Q lungq_lung_L_h | 2.9284 | L/h | Pulmonary plasma outflow normalized to the sum of modeled tissue inflows. |
Q lung published roundedq_lung_published_rounded_L_h | 2.945 | L/h | Q lung published rounded governing exchange between model compartments. |
Q muscleq_muscle_L_h | 0.925 | L/h | Q muscle governing exchange between model compartments. |
Q otherq_other_L_h | 0.105 | L/h | Q other governing exchange between model compartments. |
Q pancreasq_pancreas_L_h | 0.0634 | L/h | Q pancreas governing exchange between model compartments. |
Q pvq_pv_L_h | 7.31e-7 | L/h | Q pv governing exchange between model compartments. |
Q skinq_skin_L_h | 0.2 | L/h | Q skin governing exchange between model compartments. |
Q small intestineq_small_intestine_L_h | 0.398 | L/h | Q small intestine governing exchange between model compartments. |
Q spleenq_spleen_L_h | 0.179 | L/h | Q spleen governing exchange between model compartments. |
Q thymusq_thymus_L_h | 0.012199999999999999 | L/h | Q thymus governing exchange between model compartments. |
Rtot adiposertot_adipose_copy_L | 330000000000000 | 1/L | Rtot adipose coefficient used by the released system of model equations. |
Rtot bloodrtot_blood_copy_L | 712000000000 | 1/L | Rtot blood coefficient used by the released system of model equations. |
Rtot bonertot_bone_copy_L | 66000000000000 | 1/L | Rtot bone coefficient used by the released system of model equations. |
Rtot brainrtot_brain_copy_L | 66000000000000 | 1/L | Rtot brain coefficient used by the released system of model equations. |
Rtot heartrtot_heart_copy_L | 330000000000000 | 1/L | Rtot heart coefficient used by the released system of model equations. |
Rtot kidneyrtot_kidney_copy_L | 66000000000000 | 1/L | Rtot kidney coefficient used by the released system of model equations. |
Rtot large intestinertot_large_intestine_copy_L | 66000000000000 | 1/L | Unassigned AAV9 organ mapped to the published low receptor tier. |
Rtot liverrtot_liver_copy_L | 1600000000000000 | 1/L | Rtot liver coefficient used by the released system of model equations. |
Rtot lungrtot_lung_copy_L | 330000000000000 | 1/L | Rtot lung coefficient used by the released system of model equations. |
Rtot meningealrtot_meningeal_copy_L | 3800000000000000 | 1/L | Table 1 rounds an earlier value to 3.5e15 copy/L. |
Rtot musclertot_muscle_copy_L | 330000000000000 | 1/L | Rtot muscle coefficient used by the released system of model equations. |
Rtot otherrtot_other_copy_L | 66000000000000 | 1/L | Unassigned AAV9 organ mapped to the published low receptor tier. |
Rtot pancreasrtot_pancreas_copy_L | 66000000000000 | 1/L | Rtot pancreas coefficient used by the released system of model equations. |
Rtot skinrtot_skin_copy_L | 66000000000000 | 1/L | Rtot skin coefficient used by the released system of model equations. |
Rtot small intestinertot_small_intestine_copy_L | 66000000000000 | 1/L | Unassigned AAV9 organ mapped to the published low receptor tier. |
Rtot spleenrtot_spleen_copy_L | 330000000000000 | 1/L | Rtot spleen coefficient used by the released system of model equations. |
Rtot thymusrtot_thymus_copy_L | 66000000000000 | 1/L | Unassigned AAV9 organ mapped to the published low receptor tier. |
Sigma AAV lymphsigma_aav_lymph | 0.2 | — | Sigma AAV lymph coefficient used by the released system of model equations. |
Sigma bbbsigma_bbb | 0.9975 | — | Sigma bbb coefficient used by the released system of model equations. |
Sigma bcsfbsigma_bcsfb | 0.9973 | — | Sigma bcsfb coefficient used by the released system of model equations. |
Sigma brain isigma_brain_i | 0.2 | — | Sigma brain i coefficient used by the released system of model equations. |
Sigma csfsigma_csf | 0.2 | — | Sigma csf coefficient used by the released system of model equations. |
Sigma protein adiposesigma_protein_adipose | 0.95 | — | Sigma protein adipose coefficient used by the released system of model equations. |
Sigma protein bonesigma_protein_bone | 0.85 | — | Sigma protein bone coefficient used by the released system of model equations. |
Sigma protein heartsigma_protein_heart | 0.9 | — | Sigma protein heart coefficient used by the released system of model equations. |
Sigma protein kidneysigma_protein_kidney | 0.9 | — | Sigma protein kidney coefficient used by the released system of model equations. |
Sigma protein large intestinesigma_protein_large_intestine | 0.95 | — | Sigma protein large intestine coefficient used by the released system of model equations. |
Sigma protein liversigma_protein_liver | 0.85 | — | Sigma protein liver coefficient used by the released system of model equations. |
Sigma protein lungsigma_protein_lung | 0.95 | — | Sigma protein lung coefficient used by the released system of model equations. |
Sigma protein lymphsigma_protein_lymph | 0.2 | — | Sigma protein lymph coefficient used by the released system of model equations. |
Sigma protein musclesigma_protein_muscle | 0.95 | — | Sigma protein muscle coefficient used by the released system of model equations. |
Sigma protein othersigma_protein_other | 0.95 | — | Sigma protein other coefficient used by the released system of model equations. |
Sigma protein pancreassigma_protein_pancreas | 0.9 | — | Sigma protein pancreas coefficient used by the released system of model equations. |
Sigma protein skinsigma_protein_skin | 0.95 | — | Sigma protein skin coefficient used by the released system of model equations. |
Sigma protein small intestinesigma_protein_small_intestine | 0.9 | — | Sigma protein small intestine coefficient used by the released system of model equations. |
Sigma protein spleensigma_protein_spleen | 0.85 | — | Sigma protein spleen coefficient used by the released system of model equations. |
Sigma protein thymussigma_protein_thymus | 0.9 | — | Sigma protein thymus coefficient used by the released system of model equations. |
Sigma target vsigma_target_v | 0.3116 | — | Sigma target v coefficient used by the released system of model equations. |
Target baseline cm modeltarget_baseline_cm_model_M | 1.279456e-11 | M | Cisterna-magna baseline used to normalize the route-comparable Figure 7 CSF readout. |
Target baseline csftarget_baseline_csf_M | 2.3e-11 | M | Target baseline csf coefficient used by the released system of model equations. |
Target baseline isftarget_baseline_isf_M | 2.6e-11 | M | Target baseline isf coefficient used by the released system of model equations. |
Target baseline plasmatarget_baseline_plasma_M | 1.75e-10 | M | Target baseline plasma coefficient used by the released system of model equations. |
Target dissociation constanttarget_kd_M | 7.4e-11 | M | Target dissociation constant describing equilibrium binding affinity in the modeled interaction. |
Target dissociation ratetarget_koff_h | 0.00427 | 1/h | Target dissociation rate governing molecular dissociation in the binding model. |
Target association ratetarget_kon_per_M_h | 57702702.70270271 | 1/M/h | Target association rate governing molecular association in the binding model. |
Tau adiposetau_adipose_h | 30.3 | h | Tau adipose coefficient used by the released system of model equations. |
Tau bonetau_bone_h | 30.3 | h | Tau bone coefficient used by the released system of model equations. |
Tau braintau_brain_h | 30.3 | h | Tau brain coefficient used by the released system of model equations. |
Tau hearttau_heart_h | 69.6 | h | Tau heart coefficient used by the released system of model equations. |
Tau kidneytau_kidney_h | 30.3 | h | Tau kidney coefficient used by the released system of model equations. |
Tau large intestinetau_large_intestine_h | 30.3 | h | Tau large intestine coefficient used by the released system of model equations. |
Tau livertau_liver_h | 6.9 | h | Tau liver coefficient used by the released system of model equations. |
Tau lungtau_lung_h | 69.6 | h | Tau lung coefficient used by the released system of model equations. |
Tau muscletau_muscle_h | 69.6 | h | Tau muscle coefficient used by the released system of model equations. |
Tau othertau_other_h | 30.3 | h | Tau other coefficient used by the released system of model equations. |
Tau pancreastau_pancreas_h | 30.3 | h | Tau pancreas coefficient used by the released system of model equations. |
Tau skintau_skin_h | 30.3 | h | Tau skin coefficient used by the released system of model equations. |
Tau small intestinetau_small_intestine_h | 30.3 | h | Tau small intestine coefficient used by the released system of model equations. |
Tau spleentau_spleen_h | 69.6 | h | Tau spleen coefficient used by the released system of model equations. |
Tau thymustau_thymus_h | 30.3 | h | Tau thymus coefficient used by the released system of model equations. |
V adipose bcv_adipose_bc_L | 0.000298 | L | Rat adipose blood-cell volume. |
V adiposev_adipose_cell_L | 0.026699999999999998 | L | Rat adipose cellular volume. |
V adipose cv ev_adipose_cv_e_L | 0.0018690000000000002 | L | V adipose cv e coefficient used by the released system of model equations. |
V adipose cv pv_adipose_cv_p_L | 0.024831 | L | V adipose cv p coefficient used by the released system of model equations. |
V adipose ev_adipose_e_L | 0.000166 | L | Rat adipose endosomal volume. |
V adipose iv_adipose_i_L | 0.00563 | L | Rat adipose interstitial volume. |
V adipose totalv_adipose_total_L | 0.033100000000000004 | L | Rat adipose total volume. |
V adipose vv_adipose_v_L | 0.000364 | L | Rat adipose vascular plasma volume. |
V blood centralv_blood_central_L | 0.0009089799999999997 | L | V blood central coefficient used by the released system of model equations. |
V bone bcv_bone_bc_L | 0.000378 | L | Rat bone blood-cell volume. |
V bonev_bone_cell_L | 0.0161 | L | Rat bone cellular volume. |
V bone cv ev_bone_cv_e_L | 0.0011270000000000002 | L | V bone cv e coefficient used by the released system of model equations. |
V bone cv pv_bone_cv_p_L | 0.014973000000000002 | L | V bone cv p coefficient used by the released system of model equations. |
V bone ev_bone_e_L | 0.00010499999999999999 | L | Rat bone endosomal volume. |
V bone iv_bone_i_L | 0.0039 | L | Rat bone interstitial volume. |
V bone totalv_bone_total_L | 0.021 | L | Rat bone total volume. |
V bone vv_bone_v_L | 0.000462 | L | Rat bone vascular plasma volume. |
V brain bbbv_brain_bbb_L | 0.000009817 | L | V brain bbb coefficient used by the released system of model equations. |
V brain bcv_brain_bc_L | 0.000041 | L | Rat brain blood-cell volume. |
V brain bcsfbv_brain_bcsfb_L | 0.000001583 | L | V brain bcsfb coefficient used by the released system of model equations. |
V brainv_brain_cell_L | 0.00177 | L | Rat brain cellular volume. |
V brain cmv_brain_cm_L | 0.000017 | L | V brain cm coefficient used by the released system of model equations. |
V brain cv ev_brain_cv_e_L | 0.0001239 | L | V brain cv e coefficient used by the released system of model equations. |
V brain cv pv_brain_cv_p_L | 0.0016461000000000002 | L | V brain cv p coefficient used by the released system of model equations. |
V brain ev_brain_e_L | 0.000011400000000000001 | L | Rat brain endosomal volume. |
V brain iv_brain_i_L | 0.00041 | L | Rat brain interstitial volume. |
V brain lvv_brain_lv_L | 0.0000075 | L | V brain lv coefficient used by the released system of model equations. |
V brain menv_brain_men_L | 0.000024 | L | V brain men coefficient used by the released system of model equations. |
V brain parenchymal endov_brain_parenchymal_endo_L | 0.0003534 | L | V brain parenchymal endo coefficient used by the released system of model equations. |
V brain pv artv_brain_pv_art_L | 0.000014 | L | V brain pv art coefficient used by the released system of model equations. |
V brain pv venv_brain_pv_ven_L | 0.000014 | L | V brain pv ven coefficient used by the released system of model equations. |
V brain sasv_brain_sas_L | 0.00019 | L | V brain sas coefficient used by the released system of model equations. |
V brain tfvv_brain_tfv_L | 0.0000075 | L | V brain tfv coefficient used by the released system of model equations. |
V brain totalv_brain_total_L | 0.00228 | L | Rat brain total volume. |
V brain vv_brain_v_L | 0.0000502 | L | Rat brain vascular plasma volume. |
V heart bcv_heart_bc_L | 0.0000323 | L | Rat heart blood-cell volume. |
V heartv_heart_cell_L | 0.0008010000000000001 | L | Rat heart cellular volume. |
V heart cv ev_heart_cv_e_L | 0.00005607000000000001 | L | V heart cv e coefficient used by the released system of model equations. |
V heart cv pv_heart_cv_p_L | 0.0007449300000000001 | L | V heart cv p coefficient used by the released system of model equations. |
V heart ev_heart_e_L | 0.00000512 | L | Rat heart endosomal volume. |
V heart iv_heart_i_L | 0.000146 | L | Rat heart interstitial volume. |
V heart totalv_heart_total_L | 0.00102 | L | Rat heart total volume. |
V heart vv_heart_v_L | 0.000039399999999999995 | L | Rat heart vascular plasma volume. |
V kidney bcv_kidney_bc_L | 0.000108 | L | Rat kidney blood-cell volume. |
V kidneyv_kidney_cell_L | 0.0017900000000000001 | L | Rat kidney cellular volume. |
V kidney cv ev_kidney_cv_e_L | 0.0001253 | L | V kidney cv e coefficient used by the released system of model equations. |
V kidney cv pv_kidney_cv_p_L | 0.0016647 | L | V kidney cv p coefficient used by the released system of model equations. |
V kidney ev_kidney_e_L | 0.000012 | L | Rat kidney endosomal volume. |
V kidney iv_kidney_i_L | 0.000361 | L | Rat kidney interstitial volume. |
V kidney totalv_kidney_total_L | 0.0024100000000000002 | L | Rat kidney total volume. |
V kidney vv_kidney_v_L | 0.000132 | L | Rat kidney vascular plasma volume. |
V large intestine bcv_large_intestine_bc_L | 0.0000375 | L | Rat large_intestine blood-cell volume. |
V large intestinev_large_intestine_cell_L | 0.00228 | L | Rat large_intestine cellular volume. |
V large intestine cv ev_large_intestine_cv_e_L | 0.0001596 | L | V large intestine cv e coefficient used by the released system of model equations. |
V large intestine cv pv_large_intestine_cv_p_L | 0.0021204 | L | V large intestine cv p coefficient used by the released system of model equations. |
V large intestine ev_large_intestine_e_L | 0.0000144 | L | Rat large_intestine endosomal volume. |
V large intestine iv_large_intestine_i_L | 0.0005 | L | Rat large_intestine interstitial volume. |
V large intestine totalv_large_intestine_total_L | 0.00287 | L | Rat large_intestine total volume. |
V large intestine vv_large_intestine_v_L | 0.0000458 | L | Rat large_intestine vascular plasma volume. |
V liver bcv_liver_bc_L | 0.0011 | L | Rat liver blood-cell volume. |
V liverv_liver_cell_L | 0.0107 | L | Rat liver cellular volume. |
V liver cv ev_liver_cv_e_L | 0.000749 | L | V liver cv e coefficient used by the released system of model equations. |
V liver cv pv_liver_cv_p_L | 0.009951 | L | V liver cv p coefficient used by the released system of model equations. |
V liver ev_liver_e_L | 0.0000787 | L | Rat liver endosomal volume. |
V liver iv_liver_i_L | 0.00256 | L | Rat liver interstitial volume. |
V liver totalv_liver_total_L | 0.0157 | L | Rat liver total volume. |
V liver vv_liver_v_L | 0.00134 | L | Rat liver vascular plasma volume. |
V lung bcv_lung_bc_L | 0.000189 | L | Rat lung blood-cell volume. |
V lungv_lung_cell_L | 0.0007099999999999999 | L | Rat lung cellular volume. |
V lung cv ev_lung_cv_e_L | 0.0000497 | L | V lung cv e coefficient used by the released system of model equations. |
V lung cv pv_lung_cv_p_L | 0.0006603 | L | V lung cv p coefficient used by the released system of model equations. |
V lung ev_lung_e_L | 0.000007 | L | Rat lung endosomal volume. |
V lung iv_lung_i_L | 0.000263 | L | Rat lung interstitial volume. |
V lung totalv_lung_total_L | 0.0014 | L | Rat lung total volume. |
V lung vv_lung_v_L | 0.000231 | L | Rat lung vascular plasma volume. |
V lymphv_lymph_L | 0.00115 | L | V lymph coefficient used by the released system of model equations. |
V muscle bcv_muscle_bc_L | 0.00219 | L | Rat muscle blood-cell volume. |
V musclev_muscle_cell_L | 0.1 | L | Rat muscle cellular volume. |
V muscle cv ev_muscle_cv_e_L | 0.007000000000000001 | L | V muscle cv e coefficient used by the released system of model equations. |
V muscle cv pv_muscle_cv_p_L | 0.093 | L | V muscle cv p coefficient used by the released system of model equations. |
V muscle ev_muscle_e_L | 0.000608 | L | Rat muscle endosomal volume. |
V muscle iv_muscle_i_L | 0.0158 | L | Rat muscle interstitial volume. |
V muscle totalv_muscle_total_L | 0.122 | L | Rat muscle total volume. |
V muscle vv_muscle_v_L | 0.00268 | L | Rat muscle vascular plasma volume. |
V other bcv_other_bc_L | 0.00020899999999999998 | L | Rat other blood-cell volume. |
V otherv_other_cell_L | 0.00455 | L | Rat other cellular volume. |
V other cv ev_other_cv_e_L | 0.0003185 | L | V other cv e coefficient used by the released system of model equations. |
V other cv pv_other_cv_p_L | 0.004231500000000001 | L | V other cv p coefficient used by the released system of model equations. |
V other ev_other_e_L | 0.0000305 | L | Rat other endosomal volume. |
V other iv_other_i_L | 0.0010400000000000001 | L | Rat other interstitial volume. |
V other totalv_other_total_L | 0.00609 | L | Rat other total volume. |
V other vv_other_v_L | 0.000256 | L | Rat other vascular plasma volume. |
V pancreas bcv_pancreas_bc_L | 0.0000448 | L | Rat pancreas blood-cell volume. |
V pancreasv_pancreas_cell_L | 0.000717 | L | Rat pancreas cellular volume. |
V pancreas cv ev_pancreas_cv_e_L | 0.000050190000000000006 | L | V pancreas cv e coefficient used by the released system of model equations. |
V pancreas cv pv_pancreas_cv_p_L | 0.00066681 | L | V pancreas cv p coefficient used by the released system of model equations. |
V pancreas ev_pancreas_e_L | 0.00000498 | L | Rat pancreas endosomal volume. |
V pancreas iv_pancreas_i_L | 0.00017299999999999998 | L | Rat pancreas interstitial volume. |
V pancreas totalv_pancreas_total_L | 0.001 | L | Rat pancreas total volume. |
V pancreas vv_pancreas_v_L | 0.0000547 | L | Rat pancreas vascular plasma volume. |
V plasmav_plasma_L | 0.00115 | L | Central volume that jointly recovers the published 175/26/23 pM TargetX baselines. |
V plasma legacyv_plasma_legacy_L | 0.00906 | L | Retained for sensitivity analysis; not used by default. |
V plasma source subtractionv_plasma_source_subtraction_L | 0.00111512 | L | 9.06 mL total rat plasma minus all rounded tissue vascular plasma volumes. |
V skin bcv_skin_bc_L | 0.0015300000000000001 | L | Rat skin blood-cell volume. |
V skinv_skin_cell_L | 0.0298 | L | Rat skin cellular volume. |
V skin cv ev_skin_cv_e_L | 0.002086 | L | V skin cv e coefficient used by the released system of model equations. |
V skin cv pv_skin_cv_p_L | 0.027714000000000003 | L | V skin cv p coefficient used by the released system of model equations. |
V skin ev_skin_e_L | 0.000249 | L | Rat skin endosomal volume. |
V skin iv_skin_i_L | 0.0165 | L | Rat skin interstitial volume. |
V skin totalv_skin_total_L | 0.0499 | L | Rat skin total volume. |
V skin vv_skin_v_L | 0.0018700000000000001 | L | Rat skin vascular plasma volume. |
V small intestine bcv_small_intestine_bc_L | 0.00006510000000000001 | L | Rat small_intestine blood-cell volume. |
V small intestinev_small_intestine_cell_L | 0.00395 | L | Rat small_intestine cellular volume. |
V small intestine cv ev_small_intestine_cv_e_L | 0.0002765 | L | V small intestine cv e coefficient used by the released system of model equations. |
V small intestine cv pv_small_intestine_cv_p_L | 0.0036735 | L | V small intestine cv p coefficient used by the released system of model equations. |
V small intestine ev_small_intestine_e_L | 0.0000249 | L | Rat small_intestine endosomal volume. |
V small intestine iv_small_intestine_i_L | 0.000867 | L | Rat small_intestine interstitial volume. |
V small intestine totalv_small_intestine_total_L | 0.0049900000000000005 | L | Rat small_intestine total volume. |
V small intestine vv_small_intestine_v_L | 0.00007950000000000001 | L | Rat small_intestine vascular plasma volume. |
V spleen bcv_spleen_bc_L | 0.00027400000000000005 | L | Rat spleen blood-cell volume. |
V spleenv_spleen_cell_L | 0.00159 | L | Rat spleen cellular volume. |
V spleen cv ev_spleen_cv_e_L | 0.00011130000000000001 | L | V spleen cv e coefficient used by the released system of model equations. |
V spleen cv pv_spleen_cv_p_L | 0.0014787000000000001 | L | V spleen cv p coefficient used by the released system of model equations. |
V spleen ev_spleen_e_L | 0.0000138 | L | Rat spleen endosomal volume. |
V spleen iv_spleen_i_L | 0.000554 | L | Rat spleen interstitial volume. |
V spleen totalv_spleen_total_L | 0.00277 | L | Rat spleen total volume. |
V spleen vv_spleen_v_L | 0.000335 | L | Rat spleen vascular plasma volume. |
V thymus bcv_thymus_bc_L | 0.00000432 | L | Rat thymus blood-cell volume. |
V thymusv_thymus_cell_L | 0.0000696 | L | Rat thymus cellular volume. |
V thymus cv ev_thymus_cv_e_L | 0.000004872 | L | V thymus cv e coefficient used by the released system of model equations. |
V thymus cv pv_thymus_cv_p_L | 0.000064728 | L | V thymus cv p coefficient used by the released system of model equations. |
V thymus ev_thymus_e_L | 4.800000000000001e-7 | L | Rat thymus endosomal volume. |
V thymus iv_thymus_i_L | 0.0000163 | L | Rat thymus interstitial volume. |
V thymus totalv_thymus_total_L | 0.000096 | L | Rat thymus total volume. |
V thymus vv_thymus_v_L | 0.00000528 | L | Rat thymus vascular plasma volume. |
Validation run noncevalidation_run_nonce | 0 | — | Validation run nonce coefficient used by the released system of model equations. |
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