PKPD

Idarucizumab reversal of dabigatran in sheep

A PK/PD model coupling dabigatran central, peripheral, and effect-site disposition to idarucizumab-associated reversal of the anticoagulation response in sheep.

Explore and simulate

Therapeutic: Dabigatran challenge and idarucizumab reversal, Idarucizumab
Target: Not reported
Disease: Preclinical reversal of dabigatran anticoagulation

Biological model

A PK/PD model coupling dabigatran central, peripheral, and effect-site disposition to idarucizumab-associated reversal of the anticoagulation response in sheep.

Intervention

Dabigatran challenge and idarucizumab reversal, Idarucizumab

Biological focus

PKPD

Context

Preclinical reversal of dabigatran anticoagulation

Model details

A PK/PD model coupling dabigatran central, peripheral, and effect-site disposition to idarucizumab-associated reversal of the anticoagulation response in sheep.

Modeled states

auc mg min lmg*min/L

Modeled dynamic state for auc mg min l.
central mgmg

Modeled dynamic state for central mg.
cpb circuit mgmg

Modeled dynamic state for cpb circuit mg.
effect conc mg lmg/L

Modeled dynamic state for effect conc mg l.
idarucizumab effect unitdimensionless

Modeled dynamic state for idarucizumab effect unit.
peripheral mgmg

Modeled dynamic state for peripheral mg.

Key readouts

Dabigatran effect-site concentrationmg/L

Model-derived readout for dabigatran effect-site concentration.
Idarucizumab reversal effectdimensionless

Model-derived readout for idarucizumab reversal effect.
Central dabigatran amountmg

Model-derived readout for central dabigatran amount.
Circuit dabigatran amountmg

Model-derived readout for circuit dabigatran amount.
Cumulative dabigatran exposuremg*min/L

Model-derived readout for cumulative dabigatran exposure.

Explore this model

Choose a starting point to view its result. Adjust key model inputs when you want to explore a different outcome.

Starting configuration

4 mg/kg dabigatran sheep PK-PD

How do dabigatran effect-site kinetics and idarucizumab administration determine reversal timing? Explore this intervention regimen through Dabigatran effect-site concentration, Idarucizumab reversal effect, Central dabigatran amount, Circuit dabigatran amount, Cumulative dabigatran exposure. This is a mechanistic product exploration, not a paper-result reproduction.

Questions to explore

How do dabigatran effect-site kinetics and idarucizumab administration determine reversal timing?

Starting result

This result reflects the starting settings. Run your changes to update it.

This scenario result is temporarily unavailable.

Model inputs

Five scientist-facing controls at most.

cl std l min 70kg Model parameter controlling cl std l min 70kg. L/minv1 std l 70kg Model parameter controlling v1 std l 70kg. Lq std l min 70kg Model parameter controlling q std l min 70kg. L/mint12 keo min Model parameter controlling t12 keo min. mink ida per min Model parameter controlling k ida per min. 1/min

Compare a parameter

How does one model input change the response?

How do dabigatran effect-site kinetics and idarucizumab administration determine reversal timing?

Parameter to compare

cl std l min 70kg

Model parameter controlling cl std l min 70kg.

Exploratory range around the default value.

Low High Points

5 evenly spaced values in L/min. Other model inputs and the simulation window stay fixed.

Interpret with care

Interpret trajectories as deterministic model behavior, not as a patient-specific prediction or dosing recommendation.
Paper-result and exact-anchor checks remain in the private validation lane and are not part of this public scenario.

Review the server-confirmed fixed price before starting the comparison.

Comparative response

End-of-window response across the selected parameter values.

Choose an exploratory range around the default, review the fixed price, and run the comparison.

Scientific reference

Supporting publication

Dabigatran pharmacokinetic-pharmacodynamic in sheep: Informing dose for anticoagulation during cardiopulmonary bypass

Perfusion