Drug injury and delayed tumor loss
How does injury to proliferating tumor propagate through dying-cell stages? Explore fixed regimens and bounded dose-amplitude optimization in normalized benchmark units. No clinical dose, patient prediction, global optimum, or paper-figure agreement is claimed.
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Optimize dose amplitudes
Administration times and model parameters stay fixed. Adjust starting amplitudes within the declared bounds, then compare the optimized response with the target.
Fixed-time benchmark amplitude optimization; not a clinical regimen or a paper-optimum reproduction.
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Biology
How does injury to proliferating tumor propagate through dying-cell stages?
Assumptions & evidence
Assumptions & limitations
- Explore fixed regimens and bounded dose-amplitude optimization in normalized benchmark units. No clinical dose, patient prediction, global optimum, or paper-figure agreement is claimed.
Parameter origins
- https://github.com/Craig-Lab/DiffDose/tree/f6c39363bdd127282a555121cbe072c49dd5f276/TGI.py (make_params, initial_state, forward RHS)
Validation & references
One or more implementation checks are available; this is not a claim of full model reproduction.
No reference paper is attached to this model.
Model details
8 parameters · 6 states · 6 equations · 3 derived outputs
Classification & API access
- Therapeutic
- generic tumor-injury agent
- Modality
- Other biologic or therapeutic modality
- Target
- proliferating tumor population
- Disease / scope
- Generic tumor growth and drug-injury research
| Parameter | Default | Unit | Description |
|---|---|---|---|
Apparent distribution volumeV | 2.79 | dimensionless | Benchmark volume ratio |
Growth guardgrowth_guard | 1e-16 | 1/day | growth_guard |
Absorption rate constantka | 5 | 1/day | Absorption rate |
Elimination rate constantkel | 2.53 | 1/day | Drug elimination rate |
Drug induced tumor injury coefficientkpot | 0.0077 | 1/day | Drug-induced tumor injury coefficient |
Dying cell transit ratekt | 0.666 | 1/day | Dying-cell transit rate |
Initial tumor growth ratelam0 | 0.194 | 1/day | Initial tumor growth rate |
Limiting tumor growth ratelam1 | 0.246 | 1/day | Limiting tumor growth rate |
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