Bispecific exposure and ternary binding
How does absorbed bispecific exposure populate binary and ternary complexes? Explore fixed regimens and bounded dose-amplitude optimization in normalized benchmark units. No clinical dose, patient prediction, global optimum, or paper-figure agreement is claimed.
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Optimize dose amplitudes
Administration times and model parameters stay fixed. Adjust starting amplitudes within the declared bounds, then compare the optimized response with the target.
Fixed-time benchmark amplitude optimization; not a clinical regimen or a paper-optimum reproduction.
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Biology
How does absorbed bispecific exposure populate binary and ternary complexes?
Assumptions & evidence
Assumptions & limitations
- Explore fixed regimens and bounded dose-amplitude optimization in normalized benchmark units. No clinical dose, patient prediction, global optimum, or paper-figure agreement is claimed.
Parameter origins
- https://github.com/Craig-Lab/DiffDose/tree/f6c39363bdd127282a555121cbe072c49dd5f276/BiTE.py (make_params, initial_state, forward RHS)
Validation & references
One or more implementation checks are available; this is not a claim of full model reproduction.
No reference paper is attached to this model.
Model details
20 parameters · 8 states · 8 equations · 5 derived outputs
Classification & API access
- Therapeutic
- generic bispecific ligand
- Modality
- Bispecific antibody / T-cell engager
- Target
- generic binding partner A, generic binding partner B
- Disease / scope
- Mechanism-agnostic bispecific binding research
| Parameter | Default | Unit | Description |
|---|---|---|---|
Apparent distribution volumeV | 3 | dimensionless | Benchmark volume ratio |
K12k12 | 0 | 1/day | k12 |
K21k21 | 0.03 | 1/day | k21 |
Absorption rate constantka | 0.2 | 1/day | Absorption rate |
Degradation rate akdegA | 0.1 | 1/day | kdegA |
Degradation rate bkdegB | 0.1 | 1/day | kdegB |
Elimination rate constantkel | 0.1 | 1/day | Drug elimination rate |
Kint akintA | 0.05 | 1/day | kintA |
Ternary complex internalization ratekintAB | 0.1 | 1/day | Ternary-complex internalization rate |
Kint bkintB | 0.05 | 1/day | kintB |
KOFF1koff1 | 0.01 | 1/day | koff1 |
KOFF2koff2 | 0.01 | 1/day | koff2 |
KOFF3koff3 | 0.01 | 1/day | koff3 |
KOFF4koff4 | 0.01 | 1/day | koff4 |
KON1kon1 | 10 | 1/day | kon1 |
KON2kon2 | 1 | 1/day | kon2 |
KON3kon3 | 1 | 1/day | kon3 |
KON4kon4 | 10 | 1/day | kon4 |
Ksyn aksynA | 1 | 1/day | ksynA |
Ksyn bksynB | 10 | 1/day | ksynB |
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