SaProt
Represent proteins and compare structure-aware mutations with SaProt.
Results
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Method & evidence
Generate 1,280-value SaProt embeddings or score one exact substitution using amino-acid and precomputed 3Di tokens.
Scope & limitations
- SaProt requires supplied 3Di tokens and does not substitute amino-acid-only input.
Interpreting results
- Embeddings are model representations for comparison or downstream analysis, not measured biological properties.
- A positive mutation log-probability ratio means the pinned model prefers the submitted mutant in that structural context; it does not establish improved function, affinity, stability, or safety.
- Compare results only when sequence preparation, model version, and settings are identical.
References
Input requirements & outputs
Input checks
- Exactly one row and at most 1,000 residues
- One accepted 3Di token per amino-acid residue; all-# structure-free input is rejected
- Mutation mode requires one valid one-based XnY substitution matching the wild type
Expected results
- Structure-aware embedding Dataset — Export the complete 1,280-value vector for clustering or downstream modeling.
- Mutation-effect Dataset — Review the mutant/wild-type log-probability ratio, masked token, and exact token-block evidence.
- Sequence and 3Di context — Review the amino-acid and structural-token context used for each result.
