RFdiffusion
Generate a bounded unconditional backbone with RFdiffusion.
Results
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Method & evidence
Generate one deterministic 20–50-residue protein backbone with the RFdiffusion Base model.
Scope & limitations
- This tool supports unconditional Base-model generation only; target-conditioned and symmetry modes are not available.
- Backbone generation may take tens of seconds to minutes.
Interpreting results
- The output is an unconditional backbone proposal, not a sequence, binder, motif scaffold, or experimentally validated structure.
- Review geometry and add sequence-design and validation steps before experimental use.
- Compare repeats only when the model version, length, step count, and seed are identical.
References
Input requirements & outputs
Input checks
- Length from 20 through 50 residues
- Diffusion steps from 15 through 50
- Exactly one design with deterministic seed 0
Expected results
- Predicted backbone structure — Open the PDB and inspect residue count, backbone atoms, and coordinates.
- Generation settings — Review backbone length, diffusion steps, seed, and model alongside the structure.
