RFantibody
Design an antibody structure against a target.
Results
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Method & evidence
Run an RFdiffusion, ProteinMPNN, and RF2 cascade from an antigen target and antibody framework.
Scope & limitations
- Only the antibody-design cascade shown here is available.
- RFantibody is available on Free, Pro, and Enterprise plans.
Interpreting results
- Inspect whether redesigned loops approach the intended target hotspots without obvious clashes.
- Compare candidates only when the target, framework, hotspots, loop ranges, and seed are identical.
- The final structure is a model prediction and requires independent developability and experimental validation.
References
Input requirements & outputs
Input checks
- One target structure and one antibody framework structure
- One to eight target hotspot residues such as A123
- Explicit heavy- or light-chain loop ranges such as [H3:5-12]
Expected results
- Final RF2 structure — Open the final predicted antibody–target structure after all three stages.
- Designed sequence and stage summary — Review the proposed sequence and the completed cascade stages.
