Humanization method

Run KASearch online

Compare antibodies with patent and therapeutic references

Search PLAbDab patent references or TheraSAbDab therapeutic references and compare ranked IMGT-position identity.

Choose an approach

Scientific approaches

Select the analysis that best matches your scientific question. Each approach opens with its relevant inputs and controls.

PLAbDab patent-reference search

Available

Compare against 352,767 searchable sequences from 353,788 PLAbDab source records; 349,345 can be returned as matches.

Start this method

TheraSAbDab therapeutic-reference search

Available

Compare against 2,235 searchable therapeutic sequences from 2,237 TheraSAbDab source records.

Start this method

Prepare

Classified antibody sequences

Use a protein, annotated-sequence, or comparison Dataset with unambiguous sequences and explicit heavy/light classification.

Unambiguous antibody variable-domain sequence and chain type per row
Explicit patent-reference or therapeutic-reference collection
Up to 25 rows and 300 residues per sequence

Sequence column sequence

Chain classification antpack_chain_type

How the analysis starts

Choose a Project, open a compatible Dataset, then select the rows you want to analyze. Ubi will open this method with the compatible controls and column mappings ready to review.

Configure the scientific method

These controls appear in the Dataset analysis panel, where values can be checked against the actual input before the run starts.

Reference collection

PLAbDab patent or TheraSAbDab therapeutic

Choose the reference population that matches the scientific question.

IMGT region

Whole variable domain, CDRs, or CDR3

Select the canonical positions used for identity comparison.

Match policy

Length matching and top 1–20

Control selected-region length filtering and retained matches.

Review results as scientific outputs

Results open with the figures, structures, sequences, and metrics needed to answer the scientific question. Downloadable files remain available for downstream analysis.

How to interpret the result

PLAbDab similarity is prior-art search evidence, not a legal opinion, patentability decision, or freedom-to-operate conclusion.
TheraSAbDab similarity is therapeutic precedent evidence, not efficacy, safety, approval, or clinical-success evidence.
Compare identities only when the method, reference release, region, and length policy are identical.

Reference match ranking

Review profile-specific top matches without losing query identity.

Position-level identity evidence

Reconstruct numerator, denominator, and compared IMGT positions.

Reference collection context

See whether each match comes from the patent or therapeutic collection.

Use a complementary method on the same Project data.

AbNumber

Antibody numbering with multiple schemes

BioPhi

Humanize antibodies and score OASis repertoire prevalence

AntPack

Antibody numbering, germlines, and liabilities

Method scope and limitations

Patent and therapeutic reference populations remain separate throughout the comparison.
Patent similarity is not a legal conclusion, and therapeutic similarity is not evidence of clinical success.