Analysis method
Compare antibody self-library coverage
Score variable-region sequences with exact 8–12-mer human-proteome, paired-human-antibody, and paired-mouse-antibody Bloom-filter libraries, then optionally rank explicitly bounded framework substitutions.
Method details
Input checks
- Canonical amino acids only; 40–180 residues per chain
- Scoring accepts 1–32 rows
- Optimization accepts one row and at most 80 sorted, unique, one-based mutable positions
- Mutable positions must be framework positions selected and reviewed outside ImmunoSeq
Expected results
- Annotated score Dataset — Row-preserving global, chain, residue, reference, and result evidence.
- Ranked substitution Dataset — Mutation identity, complete candidate sequences, score delta, and candidate digest.
- Immutable native evidence — Exact request, source revision, reference manifest, method, row, candidate, and result digests.
Example result
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