Generation method

Design protein and biomolecular complexes with HalluDesign

Run the released Protenix design matrix from starting structures or random initialization with protein, ligand, DNA, RNA, symmetry, cyclic, framework, and sequence-bias controls.

Method details

Input checks

  • One to eight checksum-bound homogeneous rows
  • Supported conditioners are explicit SMILES, DNA, RNA, fixed residues/chains, bias, framework/CDR, symmetry, cyclic, and redesign controls
  • At most 32 random-init trajectories or eight starting-structure rows per native batch

Expected results

  • Designed sequence and complex table — Review row identity, design identity, sequence, status, and model evidence.
  • All-atom structures — Inspect every successful Protenix PDB result in the interactive structure viewer.
  • Conditioning and provenance evidence — Retain exact templates, constraints, image, assets, request, result, and artifact digests.
Example results
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Ubi Biologics