Unconditional sequence–structure co-design
Generate one sequence and structure together with the qualified deterministic profile.
Start this methodCo-design a protein sequence and structure
Generate one paired 40-residue protein sequence and structure for early design exploration.
Choose an approach
Scientific approaches
Select the analysis that best matches your scientific question. Each approach opens with its relevant inputs and controls.
Prepare
Design objective
This released method is an unconditional 40-residue design and does not require a source Dataset.
- One 40-residue sequence–structure pair per analysis
- Deterministic seed 0 and the qualified fast profile
- Use the result as a computational starting point, not experimental evidence
Design mode
Unconditional co-designOutput length
40 residuesHow the analysis starts
Choose a Project, open a compatible Dataset, then select the rows you want to analyze. Ubi will open this method with the compatible controls and column mappings ready to review.
Configure the scientific method
These controls appear in the Dataset analysis panel, where values can be checked against the actual input before the run starts.
Design count
1
The released operation produces one jointly generated sequence and structure.
Search profile
Fast · seed 0
The qualified fixed profile makes repeat analyses directly comparable.
Review results as scientific outputs
Results open with the figures, structures, sequences, and metrics needed to answer the scientific question. Downloadable files remain available for downstream analysis.
How to interpret the result
- Sequence and structure are generated together, so evaluate them as one design proposal.
- Inspect geometry and sequence liabilities before selecting a candidate for downstream modeling.
- Computational generation does not establish expression, stability, function, or safety.
1
Designed sequence
Review the amino-acid sequence generated jointly with the structure.
2
Designed structure
Open the paired PDB and inspect its fold and residue mapping.
Continue your analysis
Use a complementary method on the same Project data.
Method scope and limitations
- The released method is unconditional; ligand-, DNA-, RNA-, and motif-conditioned modes require separate qualification.
- DISCO is available on Free, Pro, and Enterprise plans.
