Analysis method

Predict peptide structural redistribution across environments

Estimate CD-like alpha-helical, beta-like, and unstructured fractions in four fixed environments, then compare solvent-driven shifts and structural plasticity through the qualified CPU ecosystem and production ESM API.

Method details

Input checks

  • Only the 20 canonical amino acids
  • Between 8 and 50 residues per peptide
  • Up to 16 rows and 800 total residues in one Run

Expected results

  • Four secondary-structure fraction vectors — Compare alpha-helical, beta-like, and unstructured fractions in water, methanol/water, TFE/water, and SDS micelles.
  • Structural plasticity — Review generalized Jensen–Shannon distance across the four predicted compositional vectors.
  • Water-to-environment alpha shifts — Inspect predicted changes in alpha-helical fraction relative to water for each nonaqueous condition.
Example result
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Ubi Biologics