AntPack
Annotate antibody sequences.
Results
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Method & evidence
Number antibody variable domains, assign V/J germlines, label FR/CDR regions, and inspect sequence liabilities in one analysis.
Scope & limitations
- This method annotates protein sequences; DNA translation and sequence validation are separate analyses.
Interpreting results
- Germline identity is reference similarity, not a direct immunogenicity measurement.
- Review liability calls in their numbered FR/CDR context and against assay evidence.
- Keep the reference species and numbering scheme fixed when comparing candidates.
References
Input requirements & outputs
Input checks
- Unambiguous protein sequence in the selected column
- One frozen Selection or Dataset Version
- Up to 1,000 rows and 500 residues per row
Expected results
- Chain and region annotation — Inspect numbered FR/CDR residues and chain classification.
- V/J germline assignment — Review reference genes and sequence identity scores.
- Sequence liabilities — Locate reported sequence liabilities with one-based source positions.
