Humanization method
Score, represent, restore, and review antibody sequences
Choose an AbLang2 analysis to compare sequence plausibility, create fixed-width representations, restore explicit residue masks, or rank substitutions by model probability.
Method details
Input checks
- Variable domains should contain 40–180 unambiguous amino acids per supplied chain
- Embeddings: up to 16 rows and 2,880 total residues
- Restoration: up to 8 rows, 1,440 residues, 16 literal * masks per row, and 64 masks total
- Mutation preferences: one row and up to 360 paired residues; scoring: up to 100 rows and 100,000 residues
Expected results
- Candidate score ranking — Compare confidence or pseudo-log-likelihood and pseudo-perplexity across consistently prepared candidates.
- Sequence representations — Inspect vector summaries in the result view and export complete 480-value embeddings for clustering or downstream models.
- Restored sequences and mask probabilities — Review each restored residue in sequence context with the complete canonical-amino-acid probability distribution.
- Chain-aware mutation preferences — Compare source and proposed probabilities, log-probability ratios, one-based positions, and stable ranks.
Example results
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