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Tumor, immune and stromal dynamics during combination therapy

A complete systemic–spatial tumor model connects checkpoint and kinase inhibition, immune recruitment, fibroblast activation, matrix turnover, vascular behavior and ten molecular fields.

Quantitative calibration of a spatial QSP model identifies fibroblast impact on HCC immunotherapy ↗

PNAS

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MODEL IN MOTION 18 sec

How does systemic therapy connect to spatial tumor immunity?

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Starting example

Fixed checkpoint and kinase-inhibitor context

Fixed checkpoint and kinase-inhibitor context

How do tumor cells, effector CD8 cells, activated fibroblasts, matrix amount and angiogenic signaling evolve in the fixed source combination protocol? All systemic and spatial mechanisms remain active; no clinical efficacy or paper-panel match is established.

0–70 day

Scenario details

Fixed checkpoint and kinase-inhibitor context

How do tumor cells, effector CD8 cells, activated fibroblasts, matrix amount and angiogenic signaling evolve in the fixed source combination protocol? All systemic and spatial mechanisms remain active; no clinical efficacy or paper-panel match is established.

Readouts

Cancer population 1 · cell
One modeled cancer-cell population. The source whole-tumor cancer total combines C1 and C2; C1 alone is not the total viable cancer amount.
Tumor effector CD8 T cells · cell
Effector CD8-cell amount in the systemic model tumor compartment.
Cancer-associated fibroblasts · cell
Activated fibroblast amount in the systemic tumor compartment.
Tumor extracellular matrix amount · nmol
Model extracellular-matrix amount in nanomoles; not a tissue volume.
Tumor angiogenic signal · pg/mL
Aggregate source angiogenic-factor mass concentration; not vascular volume or a direct VEGFA assay.

Study purpose

  • How do immune, stromal and tumor trajectories interact within this fixed mechanistic context?

Assumptions

  • This is one fixed source parameter and administration context, not an inferred patient population.
  • Systemic matrix amount is nmol and angiogenic signal is pg/mL; neither is a volume.
  • Regional chemical fields preserve source-native numerical values; per-field producer/threshold unit conflicts are disclosed.

Inputs changed since the displayed result. Run to update the comparison.

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Simulation time
day
day
70 → 168

Time between reported samples.

day

1 change · Variation 1

Biology

A complete systemic–spatial tumor model connects checkpoint and kinase inhibition, immune recruitment, fibroblast activation, matrix turnover, vascular behavior and ten molecular fields.

A complete systemic–spatial tumor model connects checkpoint and kinase inhibition, immune recruitment, fibroblast activation, matrix turnover, vascular behavior and ten molecular fields.

Model details

153 systemic states · 10 diffusing fields · spatial cell agents

Classification & API access
Therapeutic
Nivolumab, Cabozantinib
Modality
Monoclonal antibody
Target
PD-1 / PDCD1, VEGFR2, MET, AXL
Disease / scope
Research tumor–immune–stromal context. Cabozantinib effects are represented by the retained source pharmacodynamic terms; its individual kinase targets are background pharmacology, not separate target-occupancy outputs.

This hybrid model executes the complete source engine: 153 systemic states, 10 diffusing fields and spatial cell agents. Its constitutive code is the mathematical authority; it is not represented by substitute scalar equations.

The complete native source defines the executable mechanisms. Interpretation changes and source-unit conflicts are documented in the model card and result unit manifest.

Source: 10.5281/zenodo.17118445 · CC-BY-4.0.

Systemic output inventory (155)

The complete native engine performs pretreatment initialization. Descriptor values are not treatment-start measurements or editable initial conditions.

OutputUnitMeaning
A e M1A_e.M1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
A e M1p0A_e.M1p0molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
A e M1p1A_e.M1p1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
A s M1A_s.M1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
A s M1p0A_s.M1p0molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
A s M1p1A_s.M1p1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
V C A site1V_C.A_site1nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V C A site2V_C.A_site2nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V C T0V_C.T0cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V C T1V_C.T1cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V C ThV_C.ThcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V C aCTLA4V_C.aCTLA4nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V C aPD1V_C.aPD1nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V C aPDL1V_C.aPDL1nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V C cabozantinibV_C.cabozantinibnMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V C nT0V_C.nT0cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V C nT1V_C.nT1cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN APCV_LN.APCcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN IL2V_LN.IL2nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN T0V_LN.T0cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN T1V_LN.T1cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN ThV_LN.ThcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN aCTLA4V_LN.aCTLA4nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN aPD1V_LN.aPD1nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN aPDL1V_LN.aPDL1nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN aT0V_LN.aT0cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN aT1V_LN.aT1cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN aThV_LN.aThcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN cabozantinibV_LN.cabozantinibnMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN mAPCV_LN.mAPCcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN nT0V_LN.nT0cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V LN nT1V_LN.nT1cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V P T0V_P.T0cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V P T1V_P.T1cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V P ThV_P.ThcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V P aCTLA4V_P.aCTLA4nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V P aPD1V_P.aPD1nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V P aPDL1V_P.aPDL1nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V P cabozantinibV_P.cabozantinibnMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V P nT0V_P.nT0cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V P nT1V_P.nT1cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T APCV_T.APCcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T ArgIV_T.ArgInMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
Cancer population 1V_T.C1Primary biological readoutcellOne modeled cancer-cell population. The source whole-tumor cancer total combines C1 and C2; C1 alone is not the total viable cancer amount.
V T C2V_T.C2cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
Cancer-associated fibroblastsV_T.CAFPrimary biological readoutcellActivated fibroblast amount in the systemic tumor compartment.
V T CCL2V_T.CCL2nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T C xV_T.C_xcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
Tumor extracellular matrix amountV_T.ECMPrimary biological readoutnmolModel extracellular-matrix amount in nanomoles; not a tissue volume.
V T FibV_T.FibcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T IFNgV_T.IFNgnMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T IL10V_T.IL10nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T IL12V_T.IL12nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T KV_T.KcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T MDSCV_T.MDSCcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T Mac M1V_T.Mac_M1cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T Mac M2V_T.Mac_M2cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T NOV_T.NOnMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T P0V_T.P0mol/LUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T P1V_T.P1mol/LUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T T0V_T.T0cellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
Tumor effector CD8 T cellsV_T.T1Primary biological readoutcellEffector CD8-cell amount in the systemic model tumor compartment.
V T T1 exhV_T.T1_exhcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T TGFbV_T.TGFbnMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T ThV_T.ThcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T Th exhV_T.Th_exhcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T aCTLA4V_T.aCTLA4nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T aPD1V_T.aPD1nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T aPDL1V_T.aPDL1nMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
Tumor angiogenic signalV_T.c_vasPrimary biological readoutpg/mLAggregate source angiogenic-factor mass concentration; not vascular volume or a direct VEGFA assay.
V T cabozantinibV_T.cabozantinibnMUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V T mAPCV_T.mAPCcellUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V e P0V_e.P0mol/LUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V e P1V_e.P1mol/LUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V e p0V_e.p0mol/LUnmodified source-native systemic readout; inspect the complete model inventory for its role.
V e p1V_e.p1mol/LUnmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C CD47syn_M_C.CD47molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C CD47 SIRPasyn_M_C.CD47_SIRPamolecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C CD80syn_M_C.CD80molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C CD80msyn_M_C.CD80mmolecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C PD1syn_M_C.PD1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C PD1 PDL1syn_M_C.PD1_PDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C PD1 PDL2syn_M_C.PD1_PDL2molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C PD1 aPD1syn_M_C.PD1_aPD1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C PD1 aPD1 PD1syn_M_C.PD1_aPD1_PD1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C PDL1syn_M_C.PDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C PDL1 CD80syn_M_C.PDL1_CD80molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C PDL1 aPDL1syn_M_C.PDL1_aPDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C PDL1 aPDL1 PDL1syn_M_C.PDL1_aPDL1_PDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C PDL1 totalsyn_M_C.PDL1_totalmolecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C PDL2syn_M_C.PDL2molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C PDL2 totalsyn_M_C.PDL2_totalmolecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn M C SIRPasyn_M_C.SIRPamolecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CD28syn_T_APC.CD28molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CD28 CD80syn_T_APC.CD28_CD80molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CD28 CD80 CD28syn_T_APC.CD28_CD80_CD28molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CD28 CD86syn_T_APC.CD28_CD86molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CD80syn_T_APC.CD80molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CD80 CTLA4syn_T_APC.CD80_CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CD80 CTLA4 CD80syn_T_APC.CD80_CTLA4_CD80molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CD80 CTLA4 CD80 CTLA4syn_T_APC.CD80_CTLA4_CD80_CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CD80msyn_T_APC.CD80mmolecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CD86syn_T_APC.CD86molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CD86 CTLA4syn_T_APC.CD86_CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CD86 CTLA4 CD86syn_T_APC.CD86_CTLA4_CD86molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CTLA4syn_T_APC.CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CTLA4 CD80 CTLA4syn_T_APC.CTLA4_CD80_CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CTLA4 aCTLA4syn_T_APC.CTLA4_aCTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC CTLA4 aCTLA4 CTLA4syn_T_APC.CTLA4_aCTLA4_CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC PD1syn_T_APC.PD1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC PD1 PDL1syn_T_APC.PD1_PDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC PD1 PDL2syn_T_APC.PD1_PDL2molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC PD1 aPD1syn_T_APC.PD1_aPD1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC PD1 aPD1 PD1syn_T_APC.PD1_aPD1_PD1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC PDL1syn_T_APC.PDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC PDL1 CD80syn_T_APC.PDL1_CD80molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC PDL1 CD80 CD28syn_T_APC.PDL1_CD80_CD28molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC PDL1 CD80 CTLA4syn_T_APC.PDL1_CD80_CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC PDL1 aPDL1syn_T_APC.PDL1_aPDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC PDL1 aPDL1 PDL1syn_T_APC.PDL1_aPDL1_PDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC PDL2syn_T_APC.PDL2molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC TPDL1syn_T_APC.TPDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC TPDL1 aPDL1syn_T_APC.TPDL1_aPDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T APC TPDL1 aPDL1 TPDL1syn_T_APC.TPDL1_aPDL1_TPDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CD28syn_T_C1.CD28molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CD28 CD80syn_T_C1.CD28_CD80molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CD28 CD80 CD28syn_T_C1.CD28_CD80_CD28molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CD28 CD86syn_T_C1.CD28_CD86molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CD80syn_T_C1.CD80molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CD80 CTLA4syn_T_C1.CD80_CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CD80 CTLA4 CD80syn_T_C1.CD80_CTLA4_CD80molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CD80 CTLA4 CD80 CTLA4syn_T_C1.CD80_CTLA4_CD80_CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CD80msyn_T_C1.CD80mmolecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CD86syn_T_C1.CD86molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CD86 CTLA4syn_T_C1.CD86_CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CD86 CTLA4 CD86syn_T_C1.CD86_CTLA4_CD86molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CTLA4syn_T_C1.CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CTLA4 CD80 CTLA4syn_T_C1.CTLA4_CD80_CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CTLA4 aCTLA4syn_T_C1.CTLA4_aCTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 CTLA4 aCTLA4 CTLA4syn_T_C1.CTLA4_aCTLA4_CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 PD1syn_T_C1.PD1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 PD1 PDL1syn_T_C1.PD1_PDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 PD1 PDL2syn_T_C1.PD1_PDL2molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 PD1 aPD1syn_T_C1.PD1_aPD1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 PD1 aPD1 PD1syn_T_C1.PD1_aPD1_PD1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 PDL1syn_T_C1.PDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 PDL1 CD80syn_T_C1.PDL1_CD80molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 PDL1 CD80 CD28syn_T_C1.PDL1_CD80_CD28molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 PDL1 CD80 CTLA4syn_T_C1.PDL1_CD80_CTLA4molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 PDL1 aPDL1syn_T_C1.PDL1_aPDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 PDL1 aPDL1 PDL1syn_T_C1.PDL1_aPDL1_PDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 PDL2syn_T_C1.PDL2molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 TPDL1syn_T_C1.TPDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 TPDL1 aPDL1syn_T_C1.TPDL1_aPDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
syn T C1 TPDL1 aPDL1 TPDL1syn_T_C1.TPDL1_aPDL1_TPDL1molecule/um²Unmodified source-native systemic readout; inspect the complete model inventory for its role.
Complete spatial fields and result files

The fixed spatial grid is 50 × 50 × 50 voxels. Raw field values are preserved. A source-native concentration label identifies unresolved source annotations, not a calibrated mass or molar unit.

FieldUnitInterpretation
ArgIArgISource-native concentration (unit unresolved)SOURCE_UNIT_CONFLICT; activity/mass calibration unspecified
CCL2CCL2Source-native concentration (unit unresolved)SOURCE_UNIT_CONFLICT; retain raw values, intended interpretation only
IFNgIFNgng/mLdirect source annotation and operative thresholds agree
IL10IL10Source-native concentration (unit unresolved)SOURCE_UNIT_CONFLICT across contributors
IL12IL12ng/mLdirect source annotation and operative thresholds agree
IL 2IL_2ng/mLdirect source annotation and operative thresholds agree
NONOSource-native concentration (unit unresolved)SOURCE_UNIT_CONFLICT; retain raw values without silent rescaling
O2O2Source-native concentration (unit unresolved)SOURCE_UNIT_CONFLICT between field annotation/threshold and tension description
TGFBTGFBSource-native concentration (unit unresolved)SOURCE_UNIT_CONFLICT across contributors; no unified literal physical unit established
VEGFAVEGFAng/mLKnown producer field ng/mL; SOURCE_THRESHOLD_UNIT_CONFLICT (pg/mL annotation); no raw rescaling
ECM densityECM_densitynmol/mLoperative concentration construction supported; source secretion-per-step scaling caveat separate
Fib fieldFib_fieldWeighted kernel indexDo not label as physical cell density or molecular concentration

Full systemic trajectories, molecular and stromal grids, agent records, source protocol and unit manifest are retained as result files. No model fields or cell populations are downsampled. Open the completed Run’s result files to download them.

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