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Vedolizumab exposure across transplant covariates

A conditional two-compartment model of vedolizumab exposure in adult allogeneic stem-cell transplant research. Fixed body weight, albumin, lymphocyte count, age and GvHD flags alter clearance and distribution. It does not predict treatment outcomes, reconstruct changing patient covariates or quantify population uncertainty.

Population pharmacokinetic modeling of vedolizumab for graft‐versus‐host disease prophylaxis in adults with allogeneic hematopoietic stem cell transplant ↗

Pharmacology Research & Perspectives

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Three-infusion reference exposure

How does the three-infusion schedule shape conditional exposure?

0–180 day

Study

Three-infusion reference exposure

How does the three-infusion schedule shape conditional exposure?

Readouts

Central vedolizumab concentration· ug/mL
Conditional central concentration for the specified infusion regimen and fixed covariates; excludes patient-level and population uncertainty.
Cumulative central exposure· mg*day/L
Integral from the simulation start; an AUC interval must be selected before comparing exposure across regimens.
Conditional clearance· L/day
Fixed covariate-adjusted clearance. Exact zero lymphocytes use 0.01 K/uL; positive values remain unchanged.

Study purpose

  • How does the three-infusion schedule shape conditional exposure?

Interpretation limits

  • Covariates remain fixed for the entire simulated interval; changing patient histories and next-observation-carried-back imputation are outside this model.
  • These are conditional PK projections, with no original patient fit, population/VPC uncertainty, GvHD outcome prediction or clinical dosing recommendation.
  • The source intercompartmental-clearance body-weight exponent is unresolved: this candidate retains 0.75 provisionally; the main table prints 0.50.
  • Time is days since the first infusion, corresponding to study Day -1; dosing is fixed mass, not mg/kg.
  • Albumin is entered in g/L, normalized to 40 g/L; exactly zero lymphocytes become 0.01 K/uL, while positive counts are preserved.
  • The advanced Q-weight exponent may compare 0.75 (results/S2) and 0.50 (Table 2); the source disagreement remains unresolved.
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Physiological covariates

Body weight coefficient used by the released system of model equations.

kg

Suggested: 37.5–112.5. You can explore beyond this range.

75 → —

Albumin coefficient used by the released system of model equations.

g/L

Suggested: 20–60. You can explore beyond this range.

40 → —

Lymphocyte count coefficient used by the released system of model equations.

kilocount/uL

Suggested: 0.05–0.15. You can explore beyond this range.

0.1 → —

Age coefficient used by the released system of model equations.

year

Suggested: 26.5–79.5. You can explore beyond this range.

53 → —
PK disposition

Systemic clearance governing removal of modeled material from the relevant compartment.

L/day

Suggested: 0.074–0.222. You can explore beyond this range.

0.148 → —
Simulation time
day
day
180 → 168

Time between reported samples.

day

1 change · Variation 1

Continue in the background and keep the result.

Biology

Explore fixed two-compartment exposure in adult allogeneic stem-cell transplant context. Weight, albumin, lymphocytes, age and GvHD flags affect disposition. This PK contract does not predict prevention, treatment outcomes or source population uncertainty.

Explore fixed two-compartment exposure in adult allogeneic stem-cell transplant context. Weight, albumin, lymphocytes, age and GvHD flags affect disposition. This PK contract does not predict prevention, treatment outcomes or source population uncertainty.
States & equation dependencies
What are the modeled states and equation-linked processes?Representative technical topology with 5 selected states: Central-compartment drug amount, Peripheral-compartment drug amount, Exposure (AUC), Elapsed time, Summary marker. Displayed equation-linked dependencies: between Peripheral-compartment drug amount and Central-compartment drug amount; from Central-compartment drug amount to Exposure (AUC). Displayed model or scenario entry points: Administered input enters Central-compartment drug amount. There are no separately labeled equation controls.TECHNICAL TOPOLOGYWhat are the modeled states and equation-linked processes?Selected equation-linked states · model time unit: dayAdministered inputCentral-compartment drugamountmgPeripheral-compartment drugamountmgExposure (AUC)mg*day/LElapsed timedaySummary markerdimensionless
Teal arrows show relationships between modeled states and do not always represent material transfer. Peach arrows mark administered or scenario-defined entry points.

Assumptions & evidence

Assumptions & limitations

  • legacy population-modeling workflow control stream, analysis dataset, individual random effects, patient concentration histories, and VPC simulation draws are not public.
  • Article/SI provide VPC and diagnostic figures but no numeric source coordinates; dynamic overlays therefore use paper-reported Figure 3 covariate endpoints and dose/regimen markers.
  • The main Table 2 Q weight exponent conflicts with Results prose and Supplement Equation S2; original legacy population-modeling workflow control stream is needed for definitive adjudication.
  • Time-varying weight, albumin, and lymphocyte histories and next-observation-carried-back imputation are not represented by static curated scenario inputs.
  • Covariates remain fixed for the entire simulated interval; changing patient histories and next-observation-carried-back imputation are outside this model.
  • These are conditional PK projections, with no original patient fit, population/VPC uncertainty, GvHD outcome prediction or clinical dosing recommendation.
  • The source intercompartmental-clearance body-weight exponent is unresolved: this candidate retains 0.75 provisionally; the main table prints 0.50.
  • Time is days since the first infusion, corresponding to study Day -1; dosing is fixed mass, not mg/kg.
  • Albumin is entered in g/L, normalized to 40 g/L; exactly zero lymphocytes become 0.01 K/uL, while positive counts are preserved.
  • The advanced Q-weight exponent may compare 0.75 (results/S2) and 0.50 (Table 2); the source disagreement remains unresolved.

Parameter origins

  • Waterhouse 2024 article Table 1/2/3, Figure 3, and Supplementary Data S1.
  • Equation S2.
  • Released executable model definition; exact publication locator not reported
  • Waterhouse 2024 main Table 2 prints 0.50; main Results prose and Supplement Equation S2 text say 0.75.
  • For cache-busting validation jobs.

Validation & references

The implementation has validation evidence, but unavailable source material limits full reproduction.

Population pharmacokinetic modeling of vedolizumab for graft‐versus‐host disease prophylaxis in adults with allogeneic hematopoietic stem cell transplant ↗

Available reference curves can be added to the plot when their scenario, readout, time and units match.

Model details

268 parameters · 5 states · 5 equations · 271 derived outputs

Classification & API access
Therapeutic
Vedolizumab
Modality
Monoclonal antibody
Target
ITGA4B7, alpha4beta7 integrin, Integrin alpha4beta7
Disease / scope
GvHD prophylaxis in adults undergoing allo-HSCT
ParameterDefaultUnitDescription
Clearance ci highCL_ci_high0.162L/dayClearance ci high governing removal of modeled material from the relevant compartment.
Clearance ci lowCL_ci_low0.136L/dayClearance ci low governing removal of modeled material from the relevant compartment.
Systemic clearanceCL_l_day0.148L/daySystemic clearance governing removal of modeled material from the relevant compartment.
Clearance rse percentCL_rse_percent4.49percentClearance rse percent governing removal of modeled material from the relevant compartment.
Q ci highQ_ci_high0.612L/dayQ ci high governing exchange between model compartments.
Q ci lowQ_ci_low0.408L/dayQ ci low governing exchange between model compartments.
Intercompartmental clearanceQ_l_day0.5L/dayIntercompartmental clearance governing exchange between model compartments.
Q rse percentQ_rse_percent10.4percentQ rse percent governing exchange between model compartments.
Central distribution volume ci highVc_ci_high3.21LCentral distribution volume ci high used to convert modeled amount to concentration in the relevant compartment.
Central distribution volume ci lowVc_ci_low3.03LCentral distribution volume ci low used to convert modeled amount to concentration in the relevant compartment.
Central distribution volumeVc_l3.12LCentral distribution volume used to convert modeled amount to concentration in the relevant compartment.
Central distribution volume rse percentVc_rse_percent1.44percentCentral distribution volume rse percent used to convert modeled amount to concentration in the relevant compartment.
Peripheral distribution volume ci highVp_ci_high4.44LPeripheral distribution volume ci high used to convert modeled amount to concentration in the relevant compartment.
Peripheral distribution volume ci lowVp_ci_low3.52LPeripheral distribution volume ci low used to convert modeled amount to concentration in the relevant compartment.
Peripheral distribution volumeVp_l3.95LPeripheral distribution volume used to convert modeled amount to concentration in the relevant compartment.
Peripheral distribution volume rse percentVp_rse_percent5.93percentPeripheral distribution volume rse percent used to convert modeled amount to concentration in the relevant compartment.
Ageage_year53yearAge coefficient used by the released system of model equations.
Albuminalbumin_g_l40g/LAlbumin coefficient used by the released system of model equations.
Analysis patientsanalysis_patients193dimensionlessAnalysis patients coefficient used by the released system of model equations.
Article pdf fetched flagarticle_pdf_fetched_flag1dimensionlessArticle pdf fetched flag coefficient used by the released system of model equations.
Ava positive PHASE3 patientsava_positive_phase3_patients2dimensionlessAva positive PHASE3 patients coefficient used by the released system of model equations.
Base clearancebase_CL_l_day0.149L/dayBase clearance governing removal of modeled material from the relevant compartment.
Base qbase_Q_l_day0.585L/dayBase q governing exchange between model compartments.
Base central distribution volumebase_Vc_l3.16LBase central distribution volume used to convert modeled amount to concentration in the relevant compartment.
Base peripheral distribution volumebase_Vp_l5.03LBase peripheral distribution volume used to convert modeled amount to concentration in the relevant compartment.
Base corr clearance central distribution volumebase_corr_cl_vc0.585dimensionlessBase corr clearance central distribution volume governing removal of modeled material from the relevant compartment.
Base cov clearance central distribution volumebase_cov_cl_vc0.0545dimensionlessBase cov clearance central distribution volume governing removal of modeled material from the relevant compartment.
Base iiv clearance cv percentbase_iiv_cl_cv_percent44percentBase iiv clearance cv percent governing removal of modeled material from the relevant compartment.
Base iiv clearance variancebase_iiv_cl_variance0.177dimensionlessBase iiv clearance variance governing removal of modeled material from the relevant compartment.
Base iiv central distribution volume cv percentbase_iiv_vc_cv_percent22.5percentBase iiv central distribution volume cv percent used to convert modeled amount to concentration in the relevant compartment.
Base iiv central distribution volume variancebase_iiv_vc_variance0.0492dimensionlessBase iiv central distribution volume variance used to convert modeled amount to concentration in the relevant compartment.
Base iov clearance cv percentbase_iov_cl_cv_percent21.5percentBase iov clearance cv percent governing removal of modeled material from the relevant compartment.
Base iov clearance variancebase_iov_cl_variance0.0453dimensionlessBase iov clearance variance governing removal of modeled material from the relevant compartment.
Base proportional residual cv percentbase_proportional_residual_cv_percent15.9percentBase proportional residual cv percent coefficient used by the released system of model equations.
Base proportional residual variancebase_proportional_residual_variance0.0254dimensionlessBase proportional residual variance coefficient used by the released system of model equations.
Blq samples excludedblq_samples_excluded15dimensionlessBlq samples excluded coefficient used by the released system of model equations.
Blq samples percentblq_samples_percent0.6percentBlq samples percent coefficient used by the released system of model equations.
Citation rankcitation_rank621dimensionlessCitation rank coefficient used by the released system of model equations.
Clinically meaningful clearance effect percentclinically_meaningful_cl_effect_percent25percentClinically meaningful clearance effect percent governing removal of modeled material from the relevant compartment.
Corr clearance central distribution volumecorr_cl_vc0.415dimensionlessCorr clearance central distribution volume governing removal of modeled material from the relevant compartment.
Corr clearance peripheral distribution volumecorr_cl_vp-0.208dimensionlessCorr clearance peripheral distribution volume governing removal of modeled material from the relevant compartment.
Corr central distribution volume peripheral distribution volumecorr_vc_vp0.358dimensionlessCorr central distribution volume peripheral distribution volume used to convert modeled amount to concentration in the relevant compartment.
Cov clearance central distribution volumecov_cl_vc0.0214dimensionlessCov clearance central distribution volume governing removal of modeled material from the relevant compartment.
Cov clearance peripheral distribution volumecov_cl_vp-0.0253dimensionlessCov clearance peripheral distribution volume governing removal of modeled material from the relevant compartment.
Cov central distribution volume peripheral distribution volumecov_vc_vp0.0272dimensionlessCov central distribution volume peripheral distribution volume used to convert modeled amount to concentration in the relevant compartment.
Europepmc xml fetched flageuropepmc_xml_fetched_flag1dimensionlessEuropepmc xml fetched flag coefficient used by the released system of model equations.
FIG3 age 23y ci highfig3_age_23y_ci_high1.23dimensionlessFIG3 age 23y ci high coefficient used by the released system of model equations.
FIG3 age 23y ci lowfig3_age_23y_ci_low1.02dimensionlessFIG3 age 23y ci low coefficient used by the released system of model equations.
FIG3 age 23y covariate valuefig3_age_23y_covariate_value23yearFIG3 age 23y covariate value coefficient used by the released system of model equations.
FIG3 age 23y relative clearancefig3_age_23y_relative_cl1.11dimensionlessFIG3 age 23y relative clearance governing removal of modeled material from the relevant compartment.
FIG3 age 27y ci highfig3_age_27y_ci_high1.18dimensionlessFIG3 age 27y ci high coefficient used by the released system of model equations.
FIG3 age 27y ci lowfig3_age_27y_ci_low1.01dimensionlessFIG3 age 27y ci low coefficient used by the released system of model equations.
FIG3 age 27y covariate valuefig3_age_27y_covariate_value27yearFIG3 age 27y covariate value coefficient used by the released system of model equations.
FIG3 age 27y relative clearancefig3_age_27y_relative_cl1.09dimensionlessFIG3 age 27y relative clearance governing removal of modeled material from the relevant compartment.
FIG3 age 39y ci highfig3_age_39y_ci_high1.08dimensionlessFIG3 age 39y ci high coefficient used by the released system of model equations.
FIG3 age 39y ci lowfig3_age_39y_ci_low1.01dimensionlessFIG3 age 39y ci low coefficient used by the released system of model equations.
FIG3 age 39y covariate valuefig3_age_39y_covariate_value39yearFIG3 age 39y covariate value coefficient used by the released system of model equations.
FIG3 age 39y relative clearancefig3_age_39y_relative_cl1.04dimensionlessFIG3 age 39y relative clearance governing removal of modeled material from the relevant compartment.
FIG3 age 55y ci highfig3_age_55y_ci_high0.999dimensionlessFIG3 age 55y ci high coefficient used by the released system of model equations.
FIG3 age 55y ci lowfig3_age_55y_ci_low0.991dimensionlessFIG3 age 55y ci low coefficient used by the released system of model equations.
FIG3 age 55y covariate valuefig3_age_55y_covariate_value55yearFIG3 age 55y covariate value coefficient used by the released system of model equations.
FIG3 age 55y relative clearancefig3_age_55y_relative_cl0.995dimensionlessFIG3 age 55y relative clearance governing removal of modeled material from the relevant compartment.
FIG3 age 64y ci highfig3_age_64y_ci_high0.996dimensionlessFIG3 age 64y ci high coefficient used by the released system of model equations.
FIG3 age 64y ci lowfig3_age_64y_ci_low0.954dimensionlessFIG3 age 64y ci low coefficient used by the released system of model equations.
FIG3 age 64y covariate valuefig3_age_64y_covariate_value64yearFIG3 age 64y covariate value coefficient used by the released system of model equations.
FIG3 age 64y relative clearancefig3_age_64y_relative_cl0.977dimensionlessFIG3 age 64y relative clearance governing removal of modeled material from the relevant compartment.
FIG3 age 68y ci highfig3_age_68y_ci_high0.995dimensionlessFIG3 age 68y ci high coefficient used by the released system of model equations.
FIG3 age 68y ci lowfig3_age_68y_ci_low0.939dimensionlessFIG3 age 68y ci low coefficient used by the released system of model equations.
FIG3 age 68y covariate valuefig3_age_68y_covariate_value68yearFIG3 age 68y covariate value coefficient used by the released system of model equations.
FIG3 age 68y relative clearancefig3_age_68y_relative_cl0.97dimensionlessFIG3 age 68y relative clearance governing removal of modeled material from the relevant compartment.
FIG3 age 70y ci highfig3_age_70y_ci_high0.994dimensionlessFIG3 age 70y ci high coefficient used by the released system of model equations.
FIG3 age 70y ci lowfig3_age_70y_ci_low0.932dimensionlessFIG3 age 70y ci low coefficient used by the released system of model equations.
FIG3 age 70y covariate valuefig3_age_70y_covariate_value70yearFIG3 age 70y covariate value coefficient used by the released system of model equations.
FIG3 age 70y relative clearancefig3_age_70y_relative_cl0.966dimensionlessFIG3 age 70y relative clearance governing removal of modeled material from the relevant compartment.
FIG3 albumin 29gl ci highfig3_albumin_29gl_ci_high1.71dimensionlessFIG3 albumin 29gl ci high coefficient used by the released system of model equations.
FIG3 albumin 29gl ci lowfig3_albumin_29gl_ci_low1.38dimensionlessFIG3 albumin 29gl ci low coefficient used by the released system of model equations.
FIG3 albumin 29gl covariate valuefig3_albumin_29gl_covariate_value29g/LFIG3 albumin 29gl covariate value coefficient used by the released system of model equations.
FIG3 albumin 29gl relative clearancefig3_albumin_29gl_relative_cl1.54dimensionlessFIG3 albumin 29gl relative clearance governing removal of modeled material from the relevant compartment.
FIG3 albumin 32gl ci highfig3_albumin_32gl_ci_high1.45dimensionlessFIG3 albumin 32gl ci high coefficient used by the released system of model equations.
FIG3 albumin 32gl ci lowfig3_albumin_32gl_ci_low1.25dimensionlessFIG3 albumin 32gl ci low coefficient used by the released system of model equations.
FIG3 albumin 32gl covariate valuefig3_albumin_32gl_covariate_value32g/LFIG3 albumin 32gl covariate value coefficient used by the released system of model equations.
FIG3 albumin 32gl relative clearancefig3_albumin_32gl_relative_cl1.35dimensionlessFIG3 albumin 32gl relative clearance governing removal of modeled material from the relevant compartment.
FIG3 albumin 36gl ci highfig3_albumin_36gl_ci_high1.19dimensionlessFIG3 albumin 36gl ci high coefficient used by the released system of model equations.
FIG3 albumin 36gl ci lowfig3_albumin_36gl_ci_low1.11dimensionlessFIG3 albumin 36gl ci low coefficient used by the released system of model equations.
FIG3 albumin 36gl covariate valuefig3_albumin_36gl_covariate_value36g/LFIG3 albumin 36gl covariate value coefficient used by the released system of model equations.
FIG3 albumin 36gl relative clearancefig3_albumin_36gl_relative_cl1.15dimensionlessFIG3 albumin 36gl relative clearance governing removal of modeled material from the relevant compartment.
FIG3 albumin 40gl ci highfig3_albumin_40gl_ci_high1dimensionlessFIG3 albumin 40gl ci high coefficient used by the released system of model equations.
FIG3 albumin 40gl ci lowfig3_albumin_40gl_ci_low1dimensionlessFIG3 albumin 40gl ci low coefficient used by the released system of model equations.
FIG3 albumin 40gl covariate valuefig3_albumin_40gl_covariate_value40g/LFIG3 albumin 40gl covariate value coefficient used by the released system of model equations.
FIG3 albumin 40gl relative clearancefig3_albumin_40gl_relative_cl1dimensionlessFIG3 albumin 40gl relative clearance governing removal of modeled material from the relevant compartment.
FIG3 albumin 43gl ci highfig3_albumin_43gl_ci_high0.93dimensionlessFIG3 albumin 43gl ci high coefficient used by the released system of model equations.
FIG3 albumin 43gl ci lowfig3_albumin_43gl_ci_low0.887dimensionlessFIG3 albumin 43gl ci low coefficient used by the released system of model equations.
FIG3 albumin 43gl covariate valuefig3_albumin_43gl_covariate_value43g/LFIG3 albumin 43gl covariate value coefficient used by the released system of model equations.
FIG3 albumin 43gl relative clearancefig3_albumin_43gl_relative_cl0.907dimensionlessFIG3 albumin 43gl relative clearance governing removal of modeled material from the relevant compartment.
FIG3 albumin 46gl ci highfig3_albumin_46gl_ci_high0.869dimensionlessFIG3 albumin 46gl ci high coefficient used by the released system of model equations.
FIG3 albumin 46gl ci lowfig3_albumin_46gl_ci_low0.793dimensionlessFIG3 albumin 46gl ci low coefficient used by the released system of model equations.
FIG3 albumin 46gl covariate valuefig3_albumin_46gl_covariate_value46g/LFIG3 albumin 46gl covariate value coefficient used by the released system of model equations.
FIG3 albumin 46gl relative clearancefig3_albumin_46gl_relative_cl0.829dimensionlessFIG3 albumin 46gl relative clearance governing removal of modeled material from the relevant compartment.
FIG3 albumin 48gl ci highfig3_albumin_48gl_ci_high0.832dimensionlessFIG3 albumin 48gl ci high coefficient used by the released system of model equations.
FIG3 albumin 48gl ci lowfig3_albumin_48gl_ci_low0.739dimensionlessFIG3 albumin 48gl ci low coefficient used by the released system of model equations.
FIG3 albumin 48gl covariate valuefig3_albumin_48gl_covariate_value48g/LFIG3 albumin 48gl covariate value coefficient used by the released system of model equations.
FIG3 albumin 48gl relative clearancefig3_albumin_48gl_relative_cl0.783dimensionlessFIG3 albumin 48gl relative clearance governing removal of modeled material from the relevant compartment.
FIG3 body weight 105kg ci highfig3_body_weight_105kg_ci_high1.35dimensionlessFIG3 body weight 105kg ci high used for body-size scaling in the model.
FIG3 body weight 105kg ci lowfig3_body_weight_105kg_ci_low1.2dimensionlessFIG3 body weight 105kg ci low used for body-size scaling in the model.
FIG3 body weight 105kg covariate valuefig3_body_weight_105kg_covariate_value105kgFIG3 body weight 105kg covariate value used for body-size scaling in the model.
FIG3 body weight 105kg relative clearancefig3_body_weight_105kg_relative_cl1.27dimensionlessFIG3 body weight 105kg relative clearance used for body-size scaling in the model.
FIG3 body weight 111kg ci highfig3_body_weight_111kg_ci_high1.42dimensionlessFIG3 body weight 111kg ci high used for body-size scaling in the model.
FIG3 body weight 111kg ci lowfig3_body_weight_111kg_ci_low1.23dimensionlessFIG3 body weight 111kg ci low used for body-size scaling in the model.
FIG3 body weight 111kg covariate valuefig3_body_weight_111kg_covariate_value111kgFIG3 body weight 111kg covariate value used for body-size scaling in the model.
FIG3 body weight 111kg relative clearancefig3_body_weight_111kg_relative_cl1.32dimensionlessFIG3 body weight 111kg relative clearance used for body-size scaling in the model.
FIG3 body weight 51kg ci highfig3_body_weight_51kg_ci_high0.814dimensionlessFIG3 body weight 51kg ci high used for body-size scaling in the model.
FIG3 body weight 51kg ci lowfig3_body_weight_51kg_ci_low0.707dimensionlessFIG3 body weight 51kg ci low used for body-size scaling in the model.
FIG3 body weight 51kg covariate valuefig3_body_weight_51kg_covariate_value51kgFIG3 body weight 51kg covariate value used for body-size scaling in the model.
FIG3 body weight 51kg relative clearancefig3_body_weight_51kg_relative_cl0.759dimensionlessFIG3 body weight 51kg relative clearance used for body-size scaling in the model.
FIG3 body weight 56kg ci highfig3_body_weight_56kg_ci_high0.855dimensionlessFIG3 body weight 56kg ci high used for body-size scaling in the model.
FIG3 body weight 56kg ci lowfig3_body_weight_56kg_ci_low0.769dimensionlessFIG3 body weight 56kg ci low used for body-size scaling in the model.
FIG3 body weight 56kg covariate valuefig3_body_weight_56kg_covariate_value56kgFIG3 body weight 56kg covariate value used for body-size scaling in the model.
FIG3 body weight 56kg relative clearancefig3_body_weight_56kg_relative_cl0.812dimensionlessFIG3 body weight 56kg relative clearance used for body-size scaling in the model.
FIG3 body weight 65kg ci highfig3_body_weight_65kg_ci_high0.926dimensionlessFIG3 body weight 65kg ci high used for body-size scaling in the model.
FIG3 body weight 65kg ci lowfig3_body_weight_65kg_ci_low0.879dimensionlessFIG3 body weight 65kg ci low used for body-size scaling in the model.
FIG3 body weight 65kg covariate valuefig3_body_weight_65kg_covariate_value65kgFIG3 body weight 65kg covariate value used for body-size scaling in the model.
FIG3 body weight 65kg relative clearancefig3_body_weight_65kg_relative_cl0.903dimensionlessFIG3 body weight 65kg relative clearance used for body-size scaling in the model.
FIG3 body weight 75kg ci highfig3_body_weight_75kg_ci_high1dimensionlessFIG3 body weight 75kg ci high used for body-size scaling in the model.
FIG3 body weight 75kg ci lowfig3_body_weight_75kg_ci_low1dimensionlessFIG3 body weight 75kg ci low used for body-size scaling in the model.
FIG3 body weight 75kg covariate valuefig3_body_weight_75kg_covariate_value75kgFIG3 body weight 75kg covariate value used for body-size scaling in the model.
FIG3 body weight 75kg relative clearancefig3_body_weight_75kg_relative_cl1dimensionlessFIG3 body weight 75kg relative clearance used for body-size scaling in the model.
FIG3 body weight 88kg ci highfig3_body_weight_88kg_ci_high1.15dimensionlessFIG3 body weight 88kg ci high used for body-size scaling in the model.
FIG3 body weight 88kg ci lowfig3_body_weight_88kg_ci_low1.09dimensionlessFIG3 body weight 88kg ci low used for body-size scaling in the model.
FIG3 body weight 88kg covariate valuefig3_body_weight_88kg_covariate_value88kgFIG3 body weight 88kg covariate value used for body-size scaling in the model.
FIG3 body weight 88kg relative clearancefig3_body_weight_88kg_relative_cl1.12dimensionlessFIG3 body weight 88kg relative clearance used for body-size scaling in the model.
FIG3 intestine gvhd ci highfig3_intestine_gvhd_ci_high1.28dimensionlessFIG3 intestine gvhd ci high coefficient used by the released system of model equations.
FIG3 intestine gvhd ci lowfig3_intestine_gvhd_ci_low0.892dimensionlessFIG3 intestine gvhd ci low coefficient used by the released system of model equations.
FIG3 intestine gvhd covariate valuefig3_intestine_gvhd_covariate_value1dimensionlessFIG3 intestine gvhd covariate value coefficient used by the released system of model equations.
FIG3 intestine gvhd relative clearancefig3_intestine_gvhd_relative_cl1.08dimensionlessFIG3 intestine gvhd relative clearance governing removal of modeled material from the relevant compartment.
FIG3 liver gvhd ci highfig3_liver_gvhd_ci_high1.25dimensionlessFIG3 liver gvhd ci high coefficient used by the released system of model equations.
FIG3 liver gvhd ci lowfig3_liver_gvhd_ci_low0.834dimensionlessFIG3 liver gvhd ci low coefficient used by the released system of model equations.
FIG3 liver gvhd covariate valuefig3_liver_gvhd_covariate_value1dimensionlessFIG3 liver gvhd covariate value coefficient used by the released system of model equations.
FIG3 liver gvhd relative clearancefig3_liver_gvhd_relative_cl1.05dimensionlessFIG3 liver gvhd relative clearance governing removal of modeled material from the relevant compartment.
FIG3 lymphocyte 0 1kul ci highfig3_lymphocyte_0_1kul_ci_high1dimensionlessFIG3 lymphocyte 0 1kul ci high coefficient used by the released system of model equations.
FIG3 lymphocyte 0 1kul ci lowfig3_lymphocyte_0_1kul_ci_low1dimensionlessFIG3 lymphocyte 0 1kul ci low coefficient used by the released system of model equations.
FIG3 lymphocyte 0 1kul covariate valuefig3_lymphocyte_0_1kul_covariate_value0.1kilocount/uLFIG3 lymphocyte 0 1kul covariate value coefficient used by the released system of model equations.
FIG3 lymphocyte 0 1kul relative clearancefig3_lymphocyte_0_1kul_relative_cl1dimensionlessFIG3 lymphocyte 0 1kul relative clearance governing removal of modeled material from the relevant compartment.
FIG3 lymphocyte 0 5kul ci highfig3_lymphocyte_0_5kul_ci_high1.03dimensionlessFIG3 lymphocyte 0 5kul ci high coefficient used by the released system of model equations.
FIG3 lymphocyte 0 5kul ci lowfig3_lymphocyte_0_5kul_ci_low0.919dimensionlessFIG3 lymphocyte 0 5kul ci low coefficient used by the released system of model equations.
FIG3 lymphocyte 0 5kul covariate valuefig3_lymphocyte_0_5kul_covariate_value0.5kilocount/uLFIG3 lymphocyte 0 5kul covariate value coefficient used by the released system of model equations.
FIG3 lymphocyte 0 5kul relative clearancefig3_lymphocyte_0_5kul_relative_cl0.972dimensionlessFIG3 lymphocyte 0 5kul relative clearance governing removal of modeled material from the relevant compartment.
FIG3 lymphocyte 0kul ci highfig3_lymphocyte_0kul_ci_high1.13dimensionlessFIG3 lymphocyte 0kul ci high coefficient used by the released system of model equations.
FIG3 lymphocyte 0kul ci lowfig3_lymphocyte_0kul_ci_low0.956dimensionlessFIG3 lymphocyte 0kul ci low coefficient used by the released system of model equations.
FIG3 lymphocyte 0kul covariate valuefig3_lymphocyte_0kul_covariate_value0kilocount/uLFIG3 lymphocyte 0kul covariate value coefficient used by the released system of model equations.
FIG3 lymphocyte 0kul relative clearancefig3_lymphocyte_0kul_relative_cl1.04dimensionlessFIG3 lymphocyte 0kul relative clearance governing removal of modeled material from the relevant compartment.
FIG3 lymphocyte 1 7kul ci highfig3_lymphocyte_1_7kul_ci_high1.06dimensionlessFIG3 lymphocyte 1 7kul ci high coefficient used by the released system of model equations.
FIG3 lymphocyte 1 7kul ci lowfig3_lymphocyte_1_7kul_ci_low0.861dimensionlessFIG3 lymphocyte 1 7kul ci low coefficient used by the released system of model equations.
FIG3 lymphocyte 1 7kul covariate valuefig3_lymphocyte_1_7kul_covariate_value1.7kilocount/uLFIG3 lymphocyte 1 7kul covariate value coefficient used by the released system of model equations.
FIG3 lymphocyte 1 7kul relative clearancefig3_lymphocyte_1_7kul_relative_cl0.951dimensionlessFIG3 lymphocyte 1 7kul relative clearance governing removal of modeled material from the relevant compartment.
FIG3 lymphocyte 1kul ci highfig3_lymphocyte_1kul_ci_high1.05dimensionlessFIG3 lymphocyte 1kul ci high coefficient used by the released system of model equations.
FIG3 lymphocyte 1kul ci lowfig3_lymphocyte_1kul_ci_low0.886dimensionlessFIG3 lymphocyte 1kul ci low coefficient used by the released system of model equations.
FIG3 lymphocyte 1kul covariate valuefig3_lymphocyte_1kul_covariate_value1kilocount/uLFIG3 lymphocyte 1kul covariate value coefficient used by the released system of model equations.
FIG3 lymphocyte 1kul relative clearancefig3_lymphocyte_1kul_relative_cl0.96dimensionlessFIG3 lymphocyte 1kul relative clearance governing removal of modeled material from the relevant compartment.
FIG3 lymphocyte 2 3kul ci highfig3_lymphocyte_2_3kul_ci_high1.06dimensionlessFIG3 lymphocyte 2 3kul ci high coefficient used by the released system of model equations.
FIG3 lymphocyte 2 3kul ci lowfig3_lymphocyte_2_3kul_ci_low0.848dimensionlessFIG3 lymphocyte 2 3kul ci low coefficient used by the released system of model equations.
FIG3 lymphocyte 2 3kul covariate valuefig3_lymphocyte_2_3kul_covariate_value2.3kilocount/uLFIG3 lymphocyte 2 3kul covariate value coefficient used by the released system of model equations.
FIG3 lymphocyte 2 3kul relative clearancefig3_lymphocyte_2_3kul_relative_cl0.946dimensionlessFIG3 lymphocyte 2 3kul relative clearance governing removal of modeled material from the relevant compartment.
FIG3 skin gvhd ci highfig3_skin_gvhd_ci_high1.11dimensionlessFIG3 skin gvhd ci high coefficient used by the released system of model equations.
FIG3 skin gvhd ci lowfig3_skin_gvhd_ci_low0.951dimensionlessFIG3 skin gvhd ci low coefficient used by the released system of model equations.
FIG3 skin gvhd covariate valuefig3_skin_gvhd_covariate_value1dimensionlessFIG3 skin gvhd covariate value coefficient used by the released system of model equations.
FIG3 skin gvhd relative clearancefig3_skin_gvhd_relative_cl1.03dimensionlessFIG3 skin gvhd relative clearance governing removal of modeled material from the relevant compartment.
Iiv clearance cv percentiiv_cl_cv_percent29.4percentIiv clearance cv percent governing removal of modeled material from the relevant compartment.
Iiv clearance shrinkage percentiiv_cl_shrinkage_percent12.3percentIiv clearance shrinkage percent governing removal of modeled material from the relevant compartment.
Iiv clearance varianceiiv_cl_variance0.0827dimensionlessIiv clearance variance governing removal of modeled material from the relevant compartment.
Iiv central distribution volume cv percentiiv_vc_cv_percent18.1percentIiv central distribution volume cv percent used to convert modeled amount to concentration in the relevant compartment.
Iiv central distribution volume shrinkage percentiiv_vc_shrinkage_percent8.82percentIiv central distribution volume shrinkage percent used to convert modeled amount to concentration in the relevant compartment.
Iiv central distribution volume varianceiiv_vc_variance0.0323dimensionlessIiv central distribution volume variance used to convert modeled amount to concentration in the relevant compartment.
Iiv peripheral distribution volume cv percentiiv_vp_cv_percent44.2percentIiv peripheral distribution volume cv percent used to convert modeled amount to concentration in the relevant compartment.
Iiv peripheral distribution volume shrinkage percentiiv_vp_shrinkage_percent25.3percentIiv peripheral distribution volume shrinkage percent used to convert modeled amount to concentration in the relevant compartment.
Iiv peripheral distribution volume varianceiiv_vp_variance0.179dimensionlessIiv peripheral distribution volume variance used to convert modeled amount to concentration in the relevant compartment.
Infusion durationinfusion_duration_min30minuteInfusion duration coefficient used by the released system of model equations.
Intestine gvhd flagintestine_gvhd_flag0dimensionlessBinary condition: 0 absent, 1 present. No outcome model is implied.
Iov clearance cv percentiov_cl_cv_percent17.9percentIov clearance cv percent governing removal of modeled material from the relevant compartment.
Iov clearance shrinkage percentiov_cl_shrinkage_percent55.4percentIov clearance shrinkage percent governing removal of modeled material from the relevant compartment.
Iov clearance varianceiov_cl_variance0.0315dimensionlessIov clearance variance governing removal of modeled material from the relevant compartment.
Liver gvhd flagliver_gvhd_flag0dimensionlessBinary condition: 0 absent, 1 present. No outcome model is implied.
Lymphocyte countlymphocyte_k_ul0.1kilocount/uLLymphocyte count coefficient used by the released system of model equations.
Lymphocyte zero klymphocyte_zero_k_ul0kilocount/uLFixed dimensional zero for the existing exact-zero equality predicate; not a source coefficient or independent control.
Lymphocyte zero replacement klymphocyte_zero_replacement_k_ul0.01kilocount/uLLymphocyte zero replacement k coefficient used by the released system of model equations.
Phase1b 300mg patientsphase1b_300mg_patients21dimensionlessPhase1b 300mg patients coefficient used by the released system of model equations.
Phase1b 75mg patientsphase1b_75mg_patients3dimensionlessPhase1b 75mg patients coefficient used by the released system of model equations.
Phase1b patientsphase1b_patients24dimensionlessPhase1b patients coefficient used by the released system of model equations.
PHASE3 300mg patientsphase3_300mg_patients169dimensionlessPHASE3 300mg patients coefficient used by the released system of model equations.
PHASE3 patientsphase3_patients169dimensionlessPHASE3 patients coefficient used by the released system of model equations.
Pmcid numericpmcid_numeric11374527dimensionlessPmcid numeric coefficient used by the released system of model equations.
Pmid numericpmid_numeric39233318dimensionlessPmid numeric coefficient used by the released system of model equations.
Preprint hitspreprint_hits0dimensionlessPreprint hits coefficient used by the released system of model equations.
Proportional residual cv percentproportional_residual_cv_percent15.5percentProportional residual cv percent coefficient used by the released system of model equations.
Proportional residual shrinkage percentproportional_residual_shrinkage_percent13.8percentProportional residual shrinkage percent coefficient used by the released system of model equations.
Proportional residual varianceproportional_residual_variance0.0241dimensionlessProportional residual variance coefficient used by the released system of model equations.
Publicationpublication_year2024dimensionlessPublication coefficient used by the released system of model equations.
Queue cited by countqueue_cited_by_count2dimensionlessQueue cited by count coefficient used by the released system of model equations.
Reference agereference_age_year53yearReference age coefficient used by the released system of model equations.
Reference albumin greference_albumin_g_l40g/LReference albumin g coefficient used by the released system of model equations.
Reference lymphocyte kreference_lymphocyte_k_ul0.1kilocount/uLReference lymphocyte k coefficient used by the released system of model equations.
Reference weightreference_weight_kg75kgReference weight coefficient used by the released system of model equations.
Skin gvhd flagskin_gvhd_flag0dimensionlessBinary condition: 0 absent, 1 present. No outcome model is implied.
Supplement docx fetched flagsupplement_docx_fetched_flag1dimensionlessSupplement docx fetched flag coefficient used by the released system of model equations.
ALL patientstable1_all_patients193dimensionlessALL patients coefficient used by the released system of model equations.
Asian ALLtable1_asian_all30dimensionlessAsian ALL coefficient used by the released system of model equations.
Asian ALL percenttable1_asian_all_percent15.5percentAsian ALL percent coefficient used by the released system of model equations.
Cyclosporine ALLtable1_cyclosporine_all85dimensionlessCyclosporine ALL coefficient used by the released system of model equations.
Cyclosporine ALL percenttable1_cyclosporine_all_percent44percentCyclosporine ALL percent coefficient used by the released system of model equations.
Dose 300mg ALLtable1_dose_300mg_all190dimensionlessDose 300mg ALL defining the modeled treatment input for the explored scenario.
Dose 300mg ALL percenttable1_dose_300mg_all_percent98.4percentDose 300mg ALL percent defining the modeled treatment input for the explored scenario.
Dose 75mg ALLtable1_dose_75mg_all3dimensionlessDose 75mg ALL defining the modeled treatment input for the explored scenario.
Dose 75mg ALL percenttable1_dose_75mg_all_percent1.6percentDose 75mg ALL percent defining the modeled treatment input for the explored scenario.
Female ALLtable1_female_all83dimensionlessFemale ALL coefficient used by the released system of model equations.
Female ALL percenttable1_female_all_percent43percentFemale ALL percent coefficient used by the released system of model equations.
Intestine gvhd ALLtable1_intestine_gvhd_all17dimensionlessIntestine gvhd ALL coefficient used by the released system of model equations.
Intestine gvhd ALL percenttable1_intestine_gvhd_all_percent8.8percentIntestine gvhd ALL percent coefficient used by the released system of model equations.
Liver gvhd ALLtable1_liver_gvhd_all6dimensionlessLiver gvhd ALL coefficient used by the released system of model equations.
Liver gvhd ALL percenttable1_liver_gvhd_all_percent3.1percentLiver gvhd ALL percent coefficient used by the released system of model equations.
Male ALLtable1_male_all110dimensionlessMale ALL coefficient used by the released system of model equations.
Male ALL percenttable1_male_all_percent57percentMale ALL percent coefficient used by the released system of model equations.
Methotrexate ALLtable1_methotrexate_all148dimensionlessMethotrexate ALL coefficient used by the released system of model equations.
Methotrexate ALL percenttable1_methotrexate_all_percent76.7percentMethotrexate ALL percent coefficient used by the released system of model equations.
Skin gvhd ALLtable1_skin_gvhd_all62dimensionlessSkin gvhd ALL coefficient used by the released system of model equations.
Skin gvhd ALL percenttable1_skin_gvhd_all_percent32.1percentSkin gvhd ALL percent coefficient used by the released system of model equations.
Tacrolimus ALLtable1_tacrolimus_all108dimensionlessTacrolimus ALL coefficient used by the released system of model equations.
Tacrolimus ALL percenttable1_tacrolimus_all_percent56percentTacrolimus ALL percent coefficient used by the released system of model equations.
Ursodeoxycholic acid ALLtable1_ursodeoxycholic_acid_all157dimensionlessUrsodeoxycholic acid ALL coefficient used by the released system of model equations.
Ursodeoxycholic acid ALL percenttable1_ursodeoxycholic_acid_all_percent81.3percentUrsodeoxycholic acid ALL percent coefficient used by the released system of model equations.
White ALLtable1_white_all143dimensionlessWhite ALL coefficient used by the released system of model equations.
White ALL percenttable1_white_all_percent74.1percentWhite ALL percent coefficient used by the released system of model equations.
Printed typical weight qtable2_printed_theta_weight_q0.5dimensionlessPrinted typical weight q governing exchange between model compartments.
Typical age clearancetheta_age_cl-0.13dimensionlessTypical age clearance governing removal of modeled material from the relevant compartment.
Typical age clearance ci hightheta_age_cl_ci_high-0.0185dimensionlessTypical age clearance ci high governing removal of modeled material from the relevant compartment.
Typical age clearance ci lowtheta_age_cl_ci_low-0.242dimensionlessTypical age clearance ci low governing removal of modeled material from the relevant compartment.
Typical age clearance rse percenttheta_age_cl_rse_percent43.7percentTypical age clearance rse percent governing removal of modeled material from the relevant compartment.
Typical albumin clearancetheta_albumin_cl-1.35dimensionlessTypical albumin clearance governing removal of modeled material from the relevant compartment.
Typical albumin clearance ci hightheta_albumin_cl_ci_high-1.02dimensionlessTypical albumin clearance ci high governing removal of modeled material from the relevant compartment.
Typical albumin clearance ci lowtheta_albumin_cl_ci_low-1.67dimensionlessTypical albumin clearance ci low governing removal of modeled material from the relevant compartment.
Typical albumin clearance rse percenttheta_albumin_cl_rse_percent12.3percentTypical albumin clearance rse percent governing removal of modeled material from the relevant compartment.
Typical intestine gvhd clearancetheta_intestine_gvhd_cl1.07dimensionlessTypical intestine gvhd clearance governing removal of modeled material from the relevant compartment.
Typical intestine gvhd clearance ci hightheta_intestine_gvhd_cl_ci_high1.27dimensionlessTypical intestine gvhd clearance ci high governing removal of modeled material from the relevant compartment.
Typical intestine gvhd clearance ci lowtheta_intestine_gvhd_cl_ci_low0.87dimensionlessTypical intestine gvhd clearance ci low governing removal of modeled material from the relevant compartment.
Typical intestine gvhd clearance rse percenttheta_intestine_gvhd_cl_rse_percent9.54percentTypical intestine gvhd clearance rse percent governing removal of modeled material from the relevant compartment.
Typical liver gvhd clearancetheta_liver_gvhd_cl1.05dimensionlessTypical liver gvhd clearance governing removal of modeled material from the relevant compartment.
Typical liver gvhd clearance ci hightheta_liver_gvhd_cl_ci_high1.26dimensionlessTypical liver gvhd clearance ci high governing removal of modeled material from the relevant compartment.
Typical liver gvhd clearance ci lowtheta_liver_gvhd_cl_ci_low0.834dimensionlessTypical liver gvhd clearance ci low governing removal of modeled material from the relevant compartment.
Typical liver gvhd clearance rse percenttheta_liver_gvhd_cl_rse_percent10.3percentTypical liver gvhd clearance rse percent governing removal of modeled material from the relevant compartment.
Typical lymphocyte clearancetheta_lymphocyte_cl-0.018dimensionlessTypical lymphocyte clearance governing removal of modeled material from the relevant compartment.
Typical lymphocyte clearance ci hightheta_lymphocyte_cl_ci_high0.0164dimensionlessTypical lymphocyte clearance ci high governing removal of modeled material from the relevant compartment.
Typical lymphocyte clearance ci lowtheta_lymphocyte_cl_ci_low-0.0524dimensionlessTypical lymphocyte clearance ci low governing removal of modeled material from the relevant compartment.
Typical lymphocyte clearance rse percenttheta_lymphocyte_cl_rse_percent97.6percentTypical lymphocyte clearance rse percent governing removal of modeled material from the relevant compartment.
Typical skin gvhd clearancetheta_skin_gvhd_cl1.03dimensionlessTypical skin gvhd clearance governing removal of modeled material from the relevant compartment.
Typical skin gvhd clearance ci hightheta_skin_gvhd_cl_ci_high1.12dimensionlessTypical skin gvhd clearance ci high governing removal of modeled material from the relevant compartment.
Typical skin gvhd clearance ci lowtheta_skin_gvhd_cl_ci_low0.94dimensionlessTypical skin gvhd clearance ci low governing removal of modeled material from the relevant compartment.
Typical skin gvhd clearance rse percenttheta_skin_gvhd_cl_rse_percent4.56percentTypical skin gvhd clearance rse percent governing removal of modeled material from the relevant compartment.
Typical weight clearancetheta_weight_cl0.713dimensionlessTypical weight clearance governing removal of modeled material from the relevant compartment.
Typical weight clearance ci hightheta_weight_cl_ci_high0.902dimensionlessTypical weight clearance ci high governing removal of modeled material from the relevant compartment.
Typical weight clearance ci lowtheta_weight_cl_ci_low0.523dimensionlessTypical weight clearance ci low governing removal of modeled material from the relevant compartment.
Typical weight clearance rse percenttheta_weight_cl_rse_percent13.5percentTypical weight clearance rse percent governing removal of modeled material from the relevant compartment.
Typical weight qtheta_weight_q0.75dimensionlessSource discrepancy: results/S2 use 0.75, Table 2 prints 0.50. Compare these assumptions explicitly; neither is an estimated interval.
Typical weight central distribution volumetheta_weight_vc0.659dimensionlessTypical weight central distribution volume used to convert modeled amount to concentration in the relevant compartment.
Typical weight central distribution volume ci hightheta_weight_vc_ci_high0.778dimensionlessTypical weight central distribution volume ci high used to convert modeled amount to concentration in the relevant compartment.
Typical weight central distribution volume ci lowtheta_weight_vc_ci_low0.54dimensionlessTypical weight central distribution volume ci low used to convert modeled amount to concentration in the relevant compartment.
Typical weight central distribution volume rse percenttheta_weight_vc_rse_percent9.21percentTypical weight central distribution volume rse percent used to convert modeled amount to concentration in the relevant compartment.
Typical weight peripheral distribution volumetheta_weight_vp1dimensionlessTypical weight peripheral distribution volume used to convert modeled amount to concentration in the relevant compartment.
Validation run noncevalidation_run_nonce2026070800dimensionlessValidation run nonce coefficient used by the released system of model equations.
Vedolizumab observationsvedolizumab_observations2380dimensionlessVedolizumab observations coefficient used by the released system of model equations.
Body weightweight_kg75kgBody weight coefficient used by the released system of model equations.

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