Two-clone TROP2 ADC delivery and payload response
Deterministic mechanistic subsystem coupling apparent ADC/payload PK, molecular receptor trafficking and clone-specific response. Independently authored scientific implementation; not the complete Dogru immuno-oncology network or a clinical response-rate predictor.
Quantitative Systems Pharmacology Model for TROP-2 Targeted Antibody-Drug Conjugate in Triple-Negative Breast Cancer ↗bioRxiv
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mixed standard
Deterministic research scenario; not a source cohort, clinical recommendation, or ORR/survival estimate. Two-clone delivery/payload subsystem only; immune responses and source VPCs are excluded.
0–420 day
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Biology
Deterministic mechanistic subsystem coupling apparent ADC/payload PK, molecular receptor trafficking and clone-specific response. Independently authored scientific implementation; not the complete Dogru immuno-oncology network or a clinical response-rate predictor.
Model details
46 parameters · 21 states · 21 equations · 14 derived outputs
Classification & API access
- Therapeutic
- TROP2-targeting ADC carrying SN-38 (mechanistic research context)
- Modality
- Antibody–drug conjugate (ADC)
- Target
- TROP2
- Disease / scope
- Breast cancer
| Parameter | Default | Unit | Description |
|---|---|---|---|
ADC central volumeadc_central_volume_L | 2.77 | L | Reported apparent ADC central volume. |
ADC clearanceadc_clearance_L_h | 0.15972 | L/h | Reported ADC clearance. |
ADC intercompartmentadc_intercompartment_L_h | 0.022148 | L/h | Reported ADC distribution clearance. |
ADCadc_mg_per_nmol | 0.15 | mg/nmol | 150kDa antibody mass conversion. |
ADC peripheral volumeadc_peripheral_volume_L | 0.908 | L | Reported ADC peripheral volume. |
ADC plasma partitionadc_plasma_partition | 0.61 | — | Reported ADC plasma partition convention. |
ADC tumor exchangeadc_tumor_exchange_s | 0.00000852 | 1/s | Reported bulk tumor ADC exchange rate. |
ADC tumor partitionadc_tumor_partition | 0.24 | — | Reported ADC tumor partition convention. |
Apparent payload formationapparent_payload_formation_h | 0.0961 | 1/h | Reported fitted apparent payload formation coefficient. Not a stoichiometric linker cleavage fraction. |
Associationassociation_nM_h | 0.6 | 1/(nmol/L)/h | Converted paired fitted association estimate .004 per(ng/mL)/hour using150kDa ADC; KD=.264333nM. |
Avogadroavogadro_per_mol | 6.02214076e+23 | 1/mole | Exact SI Avogadro constant. |
Binding enabledbinding_enabled | 1 | — | Mechanism intervention: zero removes ADC-target association only. |
Cell payload inflowcell_payload_inflow | 1 | — | Mechanism intervention: zero removes extracellular uptake into both clones; efflux remains. |
Cell volumecell_volume_mL | 2.5724407845144424e-9 | mL | Reported single tumor-cell volume converted from cubic micrometres. |
Cellular volume fractioncellular_volume_fraction | 0.24 | — | Chosen retained tumor-volume convention; not a fitted patient-specific fraction. |
Cleavagecleavage_h | 0.0693 | 1/h | Reported intracellular cleavage/receptor loss rate. |
Dead cell clearancedead_cell_clearance_day | 0.1 | 1/day | Reported dead-cell clearance rate. |
Dissociationdissociation_h | 0.1586 | 1/h | Reported paired fitted dissociation estimate. |
Drug antibody ratiodrug_antibody_ratio | 7.6 | — | Reported mean payload molecules per ADC. |
High growthhigh_growth_day | 0.0072 | 1/day | Reported high-clone Gompertz growth coefficient. |
High IC50high_ic50_ng_mL | 5.41 | ng/mL | Reported high-clone representative payload potency. |
High killhigh_kill_h | 0.0121 | 1/h | Reported high-clone maximal payload killing rate. |
High targethigh_target_per_cell | 200000 | — | Reported illustrative high-clone receptor count; not a cohort distribution. |
Initial high cells billioninitial_high_cells_billion | 0.381640545491553 | — | Chosen initial high-clone size in billions; multiplier of positive log-population coordinate. |
Initial low cells billioninitial_low_cells_billion | 0.381640545491553 | — | Chosen initial low-clone size in billions; zero exactly excludes this clone. |
Internalizationinternalization_h | 0.1705 | 1/h | Reported receptor/complex internalization rate. |
Low growthlow_growth_day | 0.0072 | 1/day | Reported low-clone Gompertz growth coefficient. |
Low IC50low_ic50_ng_mL | 21.22 | ng/mL | Reported low-clone representative payload potency. |
Low killlow_kill_h | 0.005 | 1/h | Reported low-clone maximal payload killing rate. |
Low targetlow_target_per_cell | 10000 | — | Reported illustrative low-clone receptor count; not a cohort distribution. |
Payload central volumepayload_central_volume_L | 49 | L | Reported apparent free-payload central volume; formation bioavailability unresolved. |
Payload clearancepayload_clearance_L_h | 409 | L/h | Reported apparent payload clearance, not independently identified absolute clearance. |
Payload effluxpayload_efflux_h | 7.92 | 1/h | Reported cellular efflux constant. |
Payload intercompartmentpayload_intercompartment_L_h | 247 | L/h | Reported apparent payload distribution clearance. |
Payloadpayload_ng_mL_per_nM | 0.3924 | ng/mL/(nmol/L) | 392.4Da payload: one nM equals .3924ng/mL. |
Payload peripheral volumepayload_peripheral_volume_L | 2177 | L | Reported apparent free-payload peripheral volume. |
Payload tumor exchangepayload_tumor_exchange_s | 0.0026 | 1/s | Reported bulk tumor free-payload exchange rate. |
Payload tumor partitionpayload_tumor_partition | 0.44 | — | Reported free-payload bulk tumor partition convention. |
Payloadpayload_ug_per_nmol | 0.3924 | µg/nmol | Payload molecular-mass conversion. |
Payload uptakepayload_uptake_h | 14.76 | 1/h | Reported cellular uptake constant; applied to clone occupied volume, not twice the whole tumor volume. |
Receptor synthesisreceptor_synthesis_h | 0.16932474455797422 | 1/h | Reported receptor synthesis relative to nominal per-cell target abundance. |
Recyclingrecycling_h | 0.000481 | 1/h | Reported complex exocytosis rate. |
Systemic payload inflowsystemic_payload_inflow | 1 | — | Mechanism intervention: zero removes plasma-to-tumor input while retaining tumor-to-plasma efflux. |
Vascular inhibitionvascular_inhibition_day | 0.0034 | 1/day | Reported carrying-capacity inhibition coefficient with cell-volume normalization. |
Vascular reference volumevascular_reference_volume_mL | 0.001 | mL | One cubic-millimetre dimensional reference for empirical vascular inhibition law. |
Vascular stimulationvascular_stimulation_day | 4.12 | 1/day | Reported tumor carrying-capacity stimulation coefficient. |
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