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Nanoconjugate tissue delivery and delayed tumor response

Deterministic dose-equivalent central/tissue PK with delayed Gompertz tumor response, independently expressed from scientific methods and reported fixed-effect values.

Preclinical Pharmacokinetic-Pharmacodynamic Modeling of Antibody Nanoconjugates for Breast Cancer Treatment ↗

CPT: Pharmacometrics & Systems Pharmacology

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No therapy

Deterministic fixed-effect dose-equivalent scenario; no population prediction or published-curve parity is claimed.

0–70 day

Scenario details

No therapy

Deterministic fixed-effect dose-equivalent scenario; no population prediction or published-curve parity is claimed.

Readouts

Central dose · mg/kg
central dose equivalent mg kg
Tissue dose · mg/kg
tissue dose equivalent mg kg
Total tumor volume · mm^3
total tumor volume mm3

Study purpose

  • How do the model's key biological readouts change under no therapy?

Assumptions

  • Interpret patterns within this model and starting configuration; do not treat them as clinical predictions or treatment recommendations.

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Simulation time
day
day
70 → 168

Time between reported samples.

day
0.5 → 1

2 changes · Variation 1

Biology

Dose-equivalent amounts drive a conditional delayed response. Fluorescence calibration and population claims are excluded.

Dose-equivalent amounts drive a conditional delayed response. Fluorescence calibration and population claims are excluded.

Model details

10 parameters · 7 states · 7 equations · 5 derived outputs

Classification & API access
Therapeutic
Antibody nanoconjugate
Modality
Monoclonal antibody
Target
No explicit molecular target
Disease / scope
Generic solid-tumor reference system
ParameterDefaultUnitDescription
Central effect fractioncentral_effect_fraction0—Central effect fraction represented as a dimensionless fraction in the released equations.
Central loss ratecentral_loss_rate0.02121/dayCentral loss rate coefficient used by the released system of model equations.
Delivery ratedelivery_rate0.11/dayDelivery rate coefficient used by the released system of model equations.
Growth limitgrowth_limit2600mm³Growth limit governing growth in the modeled biological process.
Growth rategrowth_rate0.05651/dayGrowth rate governing growth in the modeled biological process.
Injury coefficientinjury_coefficient0.256kg/mg/dayInjury coefficient coefficient used by the released system of model equations.
Injury transit rateinjury_transit_rate0.5231/dayInjury transit rate coefficient used by the released system of model equations.
Sensitivity decay timesensitivity_decay_time3.34daySensitivity decay time governing first-order loss from the modeled system.
Therapy onsettherapy_onset18dayTherapy onset coefficient used by the released system of model equations.
Tissue loss ratetissue_loss_rate1.171/dayTissue loss rate coefficient used by the released system of model equations.

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