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Lanadelumab and the plasma kallikrein–kinin system in HAE

Plasma, endothelial-proximal and receptor-surface KKS dynamics with apparent SC lanadelumab PK and source smooth attack inputs.

A quantitative systems pharmacology model of plasma kallikrein-kinin system dysregulation in hereditary angioedema ↗

Journal of Pharmacokinetics and Pharmacodynamics

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MODEL IN MOTION 18 sec

How do the paired lanadelumab presets change bradykinin signaling?

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First sampled virtual patient, 150 mg SC q2w lanadelumab

Frozen locally regenerated SI-code virtual sample (historical seed20260707), retaining the source administration schedule and0–9400hclock. No original-author raw patient data or clinical observations.

0–9,400 hour

Scenario details

First sampled virtual patient, 150 mg SC q2w lanadelumab

Frozen locally regenerated SI-code virtual sample (historical seed20260707), retaining the source administration schedule and0–9400hclock. No original-author raw patient data or clinical observations.

Readouts

Plasma lanadelumab concentration · ug/mL
Conditional model quantity; source-state units and selected conditions apply.
Plasma bradykinin · pM
Conditional model quantity; source-state units and selected conditions apply.
Cleaved hmwk numerical percent · %
100 times free cleaved plasma HMWK divided by free cleaved plus free uncleaved plasma HMWK. HMWK-containing complexes are excluded. The equation already gives a percentage; displayed values are not rescaled.

Study purpose

  • How do the model's key biological readouts change under first sampled virtual patient, 150 mg sc q2w lanadelumab?

Assumptions

  • Conditional mechanistic simulations; no original population estimation, virtual cohort, uncertainty interval or clinical treatment recommendation.
  • The frozen locally regenerated SI-code sample (historical seed20260707) contains 47 smooth FXII-autoactivation pulses. Regimen comparisons reuse that same schedule and PK coordinates; they are paired conditional calculations, not trial reproduction.
  • Lanadelumab PK drives binding in the KKS one way. Nominal drug amount uses apparent V/F and CL/F; it is not a measured total-body antibody mass or a TMDD mass balance.
  • The 20pM bradykinin flag is instantaneous. Source episode counts require the original half-hour grid and >= threshold rule; the flag alone is not monthly attack frequency.
  • Source percentage outputs already include the factor100. Normalized cHMWK is percent of basal, equals100 at its source reference and may exceed100; it is not a probability.
  • PK parameter exploration domains are virtual-sampler truncations, not clinically validated marginal ranges. Healthy C1-INH synthesis and mean-weight typical PK are separate source conditions.
  • Observer integrals start at the selected simulation start. They do not reconstruct earlier exposure or episodes.
  • C1-INH concentration increments have no therapeutic product/IU conversion. Full phase1b, nonadherence, hypothetical drug and stochastic source workflows remain pending.

Inputs changed since the displayed result. Run to update the comparison.

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Pharmacokinetics

Apparent central volume after subcutaneous administration, in L. It divides absorbed input and apparent clearance in the concentration equation. The exploratory bounds are the pinned source virtual-patient sampling domain, not a clinical dose recommendation. Model limits: 7.52–32.7.

L
14.22 → —

Apparent clearance after subcutaneous administration, in L/h. Central loss is (CL/F)/(V/F) times plasma lanadelumab concentration. The exploratory bounds retain the source virtual-patient sampling domain. Model limits: 0.0123–0.0879.

L/h
0.0284 → —

First-order absorption rate from the subcutaneous depot, in 1/h. Absorbed depot amount enters the apparent central concentration equation. The exploratory bounds retain the source virtual-patient sampling domain. Model limits: 0.00613–0.0395.

1/h
0.0179 → —
Contact-system regulation

Constant plasma C1 inhibitor synthesis input, in nM/h. Changing synthesis does not reset the independently specified initial C1-INH concentration. The bounds span the selected HAE and healthy source settings. Model limits: 11.883–39.608.

nM/h
11.88 → —
Conditional forcing

Amplitude control for the selected smooth attack-forcing profile. Paired conditions retain the same frozen pulse schedule; this control does not specify clinical attack counts or a newly sampled patient. Model limits: 0–12.

—
12 → —
Simulation time
h
h
9400 → 168

Time between reported samples.

h
168 → 1

2 changes · Variation 1

Continue in the background and keep the result.

Biology

Plasma, endothelial-proximal and receptor-surface KKS dynamics with apparent SC lanadelumab PK and source smooth attack inputs.

Plasma, endothelial-proximal and receptor-surface KKS dynamics with apparent SC lanadelumab PK and source smooth attack inputs.

Model details

191 parameters · 65 states · 65 equations · 84 derived outputs

Classification & API access
Therapeutic
Lanadelumab
Modality
Monoclonal antibody
Target
Plasma kallikrein
Disease / scope
Hereditary angioedema due to C1-INH deficiency
ParameterDefaultUnitDescription
Aa aa fold maxAA_AA_Fold_Max12—Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Aa aa t durationAA_AA_t_duration12hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Aa steepnessAA_Steepness0.01hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Aa fold norm 001AA_fold_norm_0010.213—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 002AA_fold_norm_0020.473—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 003AA_fold_norm_0030.459—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 004AA_fold_norm_0040.438—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 005AA_fold_norm_0050.24—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 006AA_fold_norm_0060.322—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 007AA_fold_norm_0070.302—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 008AA_fold_norm_0080.494—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 009AA_fold_norm_0090.382—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 010AA_fold_norm_0100.442—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 011AA_fold_norm_0110.422—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 012AA_fold_norm_0120.299—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 013AA_fold_norm_0130.412—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 014AA_fold_norm_0140.241—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 015AA_fold_norm_0150.25—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 016AA_fold_norm_0160.376—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 017AA_fold_norm_0170.407—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 018AA_fold_norm_0180.386—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 019AA_fold_norm_0190.283—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 020AA_fold_norm_0200.258—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 021AA_fold_norm_0210.342—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 022AA_fold_norm_0220.336—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 023AA_fold_norm_0230.364—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 024AA_fold_norm_0240.519—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 025AA_fold_norm_0250.352—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 026AA_fold_norm_0260.294—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 027AA_fold_norm_0270.301—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 028AA_fold_norm_0280.323—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 029AA_fold_norm_0290.549—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 030AA_fold_norm_0300.348—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 031AA_fold_norm_0310.393—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 032AA_fold_norm_0320.385—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 033AA_fold_norm_0330.359—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 034AA_fold_norm_0340.455—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 035AA_fold_norm_0350.435—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 036AA_fold_norm_0360.493—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 037AA_fold_norm_0370.439—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 038AA_fold_norm_0380.415—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 039AA_fold_norm_0390.392—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 040AA_fold_norm_0400.312—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 041AA_fold_norm_0410.44—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 042AA_fold_norm_0420.293—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 043AA_fold_norm_0430.292—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 044AA_fold_norm_0440.333—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 045AA_fold_norm_0450.245—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 046AA_fold_norm_0460.296—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa fold norm 047AA_fold_norm_0470.327—Acute attack normalized fold for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 001AA_onset_0011153.9hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 002AA_onset_0021224.1hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 003AA_onset_0031500.8hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 004AA_onset_0041551.7hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 005AA_onset_0051633hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 006AA_onset_0061896.3hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 007AA_onset_0072121.8hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 008AA_onset_0082325.4hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 009AA_onset_0092400.7hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 010AA_onset_0102466.1hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 011AA_onset_0112518.4hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 012AA_onset_0122619.2hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 013AA_onset_0132812.7hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 014AA_onset_0142904.5hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 015AA_onset_0153070.5hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 016AA_onset_0163358.5hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 017AA_onset_0173718.2hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 018AA_onset_0183876.8hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 019AA_onset_0194199.4hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 020AA_onset_0204256.5hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 021AA_onset_0214304.9hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 022AA_onset_0224643.6hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 023AA_onset_0235023.5hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 024AA_onset_0245229.4hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 025AA_onset_0255440.4hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 026AA_onset_0266371.5hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 027AA_onset_0276429.2hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 028AA_onset_0286992.2hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 029AA_onset_0297550.9hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 030AA_onset_0307632.9hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 031AA_onset_0317742.2hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 032AA_onset_0327977.6hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 033AA_onset_0338026.8hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 034AA_onset_0348167.3hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 035AA_onset_0358764.4hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 036AA_onset_0368889.3hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 037AA_onset_0379281hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 038AA_onset_0389389.5hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 039AA_onset_0399514.9hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 040AA_onset_0409615.9hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 041AA_onset_0419746.1hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 042AA_onset_04210035hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 043AA_onset_04310576.6hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 044AA_onset_04411582hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 045AA_onset_04511939.3hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 046AA_onset_04612066.3hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Aa onset 047AA_onset_04712201.3hAcute attack onset for the frozen locally regenerated SI-code virtual sample (historical seed20260707).
Bk thresholdBK_threshold0.02nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs avogadroCS_Avogadro6.02e+23count/molAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs cldCS_CLD2.88e-13L/cell/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs cld bkCS_CLD_BK8.64e-12L/cell/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs init BDKRB2CS_INIT_BDKRB2100000count/cellAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs init C1 inh in plasmaCS_INIT_C1Inh_in_plasma720nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs init fxii in plasmaCS_INIT_FXII_in_plasma375nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs init hmwk in plasmaCS_INIT_HMWK_in_plasma670nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs init g c1q rCS_INIT_gC1qR100000count/cellAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs init pre kal in plasmaCS_INIT_preKAL_in_plasma450nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs dissociation constant kal lanadelumabCS_KD_KAL_Lanadelumab0.12nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs dissociation constant bk BDKRB2CS_Kd_BK_BDKRB20.5nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs dissociation constant C1 inh fxiiaCS_Kd_C1Inh_FXIIa1720nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs dissociation constant C1 inh kalCS_Kd_C1Inh_KAL150nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs dissociation constant fxii g c1q rCS_Kd_FXII_gC1qR144nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs dissociation constant fxiia g c1q rCS_Kd_FXIIa_gC1qR144nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs dissociation constant HK2 chain g c1q rCS_Kd_HK2Chain_gC1qR10.35nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs dissociation constant hmwk g c1q rCS_Kd_HMWK_gC1qR10.35nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs dissociation constant kal HK2 chainCS_Kd_KAL_HK2Chain72nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs dissociation constant kal hmwkCS_Kd_KAL_HMWK15nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs dissociation constant pre kal hmwkCS_Kd_preKAL_HMWK12nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs km fxii activationCS_Km_FXII_Activation510nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs km fxii auto activationCS_Km_FXII_AutoActivation110nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs km pre kal activationCS_Km_preKAL_Activation91nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs mw bkCS_MW_BK1060g/molAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs mw C1 inhCS_MW_C1Inh105000g/molAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs mw fxiiCS_MW_FXII80000g/molAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs mw hkCS_MW_HK120000g/molAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs mw pre kalCS_MW_preKAL85000g/molAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs num of exchange rxnCS_Num_of_Exchange_Rxn10—Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs num of plasma rxnCS_Num_of_Plasma_Rxn23—Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs num of surface rxnCS_Num_of_Surface_Rxn29—Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs num to conc converterCS_Num_to_Conc_converter0.207641196013289nM·cell/countAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs vmediumCS_Vmedium1.23e-12L/cellAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs vproximalCS_Vproximal8e-15L/cellAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs kcat fxii activationCS_kcat_FXII_Activation151/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs kcat fxii auto activationCS_kcat_FXII_AutoActivation0.04751/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs kcat hmwk cleavageCS_kcat_HMWK_cleavage394.741/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs kcat pre kal activationCS_kcat_preKAL_Activation181/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs degradation rate BDKRB2CS_kdeg_BDKRB20.3465735902799731/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs degradation rate bkCS_kdeg_BK55.45177444479561/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs degradation rate bound C1 inhCS_kdeg_Bound_C1Inh13.86294361119891/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs degradation rate C1 inhCS_kdeg_C1Inh0.01650350429904631/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs degradation rate fxiiCS_kdeg_FXII0.01155245300933241/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs degradation rate fxiiaCS_kdeg_FXIIa8.317766166719341/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs degradation rate hmwkCS_kdeg_HMWK0.004414950194649331/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs degradation rate kalCS_kdeg_KAL8.317766166719341/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs degradation rate lanadelumab kal hmwk g c1q rCS_kdeg_Lanadelumab_KAL_HMWK_gC1qR0.3465735902799731/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs degradation rate c hmwkCS_kdeg_cHMWK0.06180930272509071/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs degradation rate g c1q rCS_kdeg_gC1qR0.3465735902799731/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs degradation rate pre kalCS_kdeg_preKAL0.0288811325233311/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs association rate bk BDKRB2CS_kon_BK_BDKRB2361/(nM·h)Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs association rate C1 inh fxiiaCS_kon_C1Inh_FXIIa0.13321/(nM·h)Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs association rate C1 inh kalCS_kon_C1Inh_KAL0.06121/(nM·h)Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs association rate fxii g c1q rCS_kon_FXII_gC1qR0.44281/(nM·h)Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs association rate fxiia g c1q rCS_kon_FXIIa_gC1qR0.44281/(nM·h)Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs association rate HK2 chain g c1q rCS_kon_HK2Chain_gC1qR0.44281/(nM·h)Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs association rate hmwk g c1q rCS_kon_HMWK_gC1qR0.44281/(nM·h)Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs association rate kal HK2 chainCS_kon_KAL_HK2Chain4.4281/(nM·h)Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs association rate kal hmwkCS_kon_KAL_HMWK4.4281/(nM·h)Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs association rate kal lanadelumabCS_kon_KAL_Lanadelumab12.0961/(nM·h)Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs association rate pre kal hmwkCS_kon_preKAL_HMWK4.4281/(nM·h)Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs ksyn BDKRB2CS_ksyn_BDKRB234657.3590279973count/cell/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs ksyn C1 inhCS_ksyn_C1Inh11.883nM/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs ksyn fxiiCS_ksyn_FXII10.83042nM/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs ksyn hmwkCS_ksyn_HMWK39.93322nM/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs ksyn g c1q rCS_ksyn_gC1qR34657.3590279973count/cell/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs ksyn pre kalCS_ksyn_preKAL41.58883nM/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs prct HK2 chain basalCS_prct_HK2Chain_basal35.6—Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs scaling factorCS_scaling_factor1000000000—Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs thalf BDKRB2CS_thalf_BDKRB22hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs thalf bkCS_thalf_BK0.0125hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs thalf bound C1 inhCS_thalf_Bound_C1Inh0.05hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs thalf C1 inhCS_thalf_C1Inh42hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs thalf fxiiCS_thalf_FXII60hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs thalf fxiiaCS_thalf_FXIIa0.0833333333333333hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs thalf hmwkCS_thalf_HMWK157hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs thalf kalCS_thalf_KAL0.0833333333333333hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs thalf c hmwkCS_thalf_cHMWK11.2142857142857hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs thalf g c1q rCS_thalf_gC1qR2hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Cs thalf pre kalCS_thalf_preKAL24hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Dose amountDose_amount150mgAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Dose intervalDose_interval336hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Init conc negligibleINIT_Conc_Negligible0nMAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
N doseN_dose13—Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Num of aaNum_of_AA47—Author SI parameter extracted from the R parameter/input files or generated Param_AA.h.
PK clearance fPK_CL_F0.0284L/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
PK mwPK_MW150000g/molAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
PK v fPK_V_F14.22LAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
PK absorption ratePK_ka0.01791/hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Basal equilibrium durationbasal_equilibrium_duration1000hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Duration post last doseduration_post_last_dose2016hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Run in periodrun_in_period2016hAuthor SI parameter extracted from the R parameter/input files or generated Param_AA.h.
Validation run noncevalidation_run_nonce0—Unused nonce to avoid exact-validation job cache collisions.

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