Rat-brain antibody and target response — reduced companion

IST 2.5E11 Vg AAV9 — fixed expression profile

Specified fixed initial drivers, local protein/target concentrations and hour calendar; no administered dose events.

Readouts

Mab plasma · nM

Declared local concentration, dimensionless driver, flux or nonfeedback accounting quantity.

Mab isf · nM

Declared local concentration, dimensionless driver, flux or nonfeedback accounting quantity.

Target isf pct baseline · dimensionless

Declared local concentration, dimensionless driver, flux or nonfeedback accounting quantity.

Study purpose

• How do the model's key biological readouts change under ist 2.5e11 vg aav9 — fixed expression profile?

Assumptions

• Three independent local concentration systems represent plasma, brain interstitial fluid and CSF. There are no inter-space flows or compartment volumes.
• Transient, durable and lagged expression drivers are dimensionless authored inputs; they are not measured vector copies, administered vector doses or observed nuclear DNA.
• Profile route, dose and serotype labels identify fixed authored initial-condition sets. No administration, dose-to-transduction or vector transport law is represented.
• Production scales, effective loss rates and initial drivers are authored conditional inputs; original profile fitting is outside this scope.
• Human binding affinity is assumed for rat. Target baselines are primary-model equilibrium predictions used as specified setpoints, not independent measured concentrations.
• A common effective target-turnover closure and a single-stage expression lag are declared assumptions.
• Each complex contains one antibody and one target. Accounting remains a local concentration balance; no cross-space mass or volume-weighted conservation is asserted.
• Forty read-only primary reference facts provide context and do not enter the companion equations or represent additional simulated observations.
• No whole-primary-model, published-figure, sampled-population, clinical translation, immunogenicity or gene-delivery optimization result is assigned.