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Anti-CD66 · fixed antigen constraint1

Fixed antibody distribution, mono/bivalent CD66 binding, single-radiolabel turnover and finite-window measurement accounting.

Physiologically Based Pharmacokinetic Modeling Is Essential in90Y-Labeled Anti-CD66 Radioimmunotherapy ↗
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MODEL IN MOTION 18 sec

How does antibody reactivity change serum and marrow label under antigen constraint 1?

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Tracer reference · 6days

Specified constant reference coefficients and matched material inputs; no individual parameter estimation or clinical dose selection.

0–144 hour

Scenario details

Tracer reference · 6days

Specified constant reference coefficients and matched material inputs; no individual parameter estimation or clinical dose selection.

Readouts

Serum label · nmol/L
Serum radiolabel signal, including weighted degradation material; SI Eq19.
Liver roi label · nmol
Liver measurement-region model signal; SI Eq17.
Marrow label · nmol
Whole red-marrow model signal, including vascular background.
Wholebody label · nmol
Retained labeled material; excludes excreted material.
Finite tia marrow · hour
Finite-window time-integrated signal divided by the specified labeled input; no infinite-tail or absorbed-dose inference.

Study purpose

  • How do the model's key biological readouts change under tracer reference · 6days?

Assumptions

  • Single-isotope material reference.
  • Mean coefficients and supplied body/organ-size inputs define one mathematical context.
  • Finite-window integrals do not calculate absorbed radiation dose.

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Simulation time
h
h
144 → 168

Time between reported samples.

h
144 → 1

2 changes · Variation 1

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Biology

One-isotope fixed-reference PBPK with explicit reactivity classes, antigen occupancy, measured-signal functions and material accounting.

One-isotope fixed-reference PBPK with explicit reactivity classes, antigen occupancy, measured-signal functions and material accounting.

Model details

43 parameters · 91 states · 91 equations · 28 derived outputs

Classification & API access
Therapeutic
Anti-CD66 antibody BW250/183
Modality
Monoclonal antibody
Target
CD66
Disease / scope
Acute leukemia conditioning
ParameterDefaultUnitDescription
BwBW_kg70kgFixed matched physical coefficient or administration-reference quantity; editing is disabled.
EE16720001/cmFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Ht cmHT_cm170cmFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Apparent distribution volumeV2.99LFixed matched physical coefficient or administration-reference quantity; editing is disabled.
VroiVroi0.03LFixed matched physical coefficient or administration-reference quantity; editing is disabled.
AgagL0.31nmolFixed matched physical coefficient or administration-reference quantity; editing is disabled.
AgagS0.22nmolFixed matched physical coefficient or administration-reference quantity; editing is disabled.
C rmcRM1.22—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
Dose reference nmolsdose_reference_nmols3.2517240896539032nmolFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Dose total nmolsdose_total_nmols3.2517240896539032nmolFixed matched physical coefficient or administration-reference quantity; editing is disabled.
ExexL0.235—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
ExexS0.107—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
F rmfRM0.0067—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
Flow giflowGI0.16—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
Circuit flow rateflowL0.065—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
Circuit flow rateflowS0.03—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
Flow total per vflow_total_per_V73.81/hFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Frac labeledfracLabeled0.021619999999999997—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
Frac vgifracVGI0.076—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
Frac vlfracVL0.1—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
Frac vrmfracVRM0.04—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
Frac vsfracVS0.014—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
Half association factorhalf_association_factor2—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
IntintL0.04—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
IntintS0.04—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
Kinkin0.1021/hFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Dissociation ratekoff3.59999999999999961/hFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Association ratekon0.36L/(nmol·h)Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
Turnover loss ratekout0.31/hFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Lambda clearancelambdaCl2.821/hFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Lambda clexlambdaClex0.002341/hFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Lambda dblambdaDb0.004081/hFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Lambda dulambdaDu0.02341/hFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Lambda META1lambdaMeta123.4000000000000021/hFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Lambda META2lambdaMeta210.2000000000000011/hFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Lambda META3lambdaMeta31.07999999999999981/hFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Lambda META4lambdaMeta40.77999999999999991/hFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Lambda phylambdaPhy0.0103200000000000011/hFixed matched physical coefficient or administration-reference quantity; editing is disabled.
N cell rmnCellRM_per_kg188000000001/kgFixed matched physical coefficient or administration-reference quantity; editing is disabled.
Organ fractionorgan_fraction0.9—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
R cell umrCell_um6umFixed matched physical coefficient or administration-reference quantity; editing is disabled.
R imrIm0.801—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.
Ratio rm bratioRM_B38—Fixed matched physical coefficient or administration-reference quantity; editing is disabled.

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