Infliximab exposure during pediatric induction

Standard 5mgkg induction typical full ode

Conditional fixed-parameter IV exposure; nominal administrations, not individual patient data.

Readouts

Central concentration · mg/L

Conditional model quantity; exposure and elimination integrals are added nonfeedback accounting readouts.

Exposure (AUC) · mg*day/L

Conditional model quantity; exposure and elimination integrals are added nonfeedback accounting readouts.

Clearance · L/day

Conditional model quantity; exposure and elimination integrals are added nonfeedback accounting readouts.

Accounted amount · mg

Conditional model quantity; exposure and elimination integrals are added nonfeedback accounting readouts.

Study purpose

• How do the model's key biological readouts change under standard 5mgkg induction typical full ode?

Assumptions

• Conditional typical-parameter pediatric induction PK; no observed cohort curve, individual prediction or clinical-response probability is reproduced.
• Reference weight is 51.2 kg and albumin 4.2 g/dL. Central-volume convention uses the reported final estimate 3.43 L.
• Weight is held at the administration reference in the default interactive contexts. Amounts are fixed at 256 or 512 mg; another weight requires explicit dose recalculation.
• Days 0, 14 and 42 and two-hour infusions are declared nominal scenario conventions, not a common published patient event array.
• Use predose sides for day 14 and day 42 troughs. Observer integrals do not introduce clinical-response dynamics.
• The low-albumin context is a marginal baseline IQR endpoint, not a clinical threshold or an observed joint patient.
• Original random-effect draws, statistical fitting, VPCs and patient-level assay comparisons are not reconstructed.