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Enfortumab and brentuximab vedotin conditional amount reference

Two ADC amount pools feed a stoichiometric MMAE amount pool with fixed context-specific disposition coefficients.

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MODEL IN MOTION 18 sec

How does prescribed MMAE clearance change exposure after enfortumab vedotin?

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Enfortumab declared amount reference; ev_single_1p25mgkg

Fixed conditional enfortumab amount reference with nominal72kg dose conversion and prescribed effective disposition constants.

0–168 hour

Scenario details

Enfortumab declared amount reference; ev_single_1p25mgkg

Fixed conditional enfortumab amount reference with nominal72kg dose conversion and prescribed effective disposition constants.

Readouts

ADC concentration · ug/mL
Deterministic amount-domain or concentration-domain readout in the stated physical unit.
MMAE concentration · ng/mL
Deterministic amount-domain or concentration-domain readout in the stated physical unit.
ADC accounted · mg
Current ADC amount plus accumulated ADC elimination; compare with delivered ADC mass.
MMAE accounted · mg
Current MMAE amount plus accumulated MMAE elimination; compare with stoichiometric cumulative MMAE formation.

Study purpose

  • How do the model's key biological readouts change under enfortumab declared amount reference; ev_single_1p25mgkg?

Assumptions

  • Interpret patterns within this model and starting configuration; do not treat them as clinical predictions or treatment recommendations.
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Simulation time
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h

Time between reported samples.

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Starting settings · Variation 1

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Biology

Two ADC amount pools feed a stoichiometric MMAE amount pool with fixed context-specific disposition coefficients.

Two ADC amount pools feed a stoichiometric MMAE amount pool with fixed context-specific disposition coefficients.

Model details

13 parameters · 6 states · 6 equations · 14 derived outputs

Classification & API access
Therapeutic
Enfortumab vedotin, brentuximab vedotin and MMAE, Enfortumab vedotin, Brentuximab vedotin, Monomethyl auristatin E
Modality
Antibody–drug conjugate (ADC)
Target
PVRL4, Nectin-4
Disease / scope
Fixed ADC and payload exposure research conditions
ParameterDefaultUnitDescription
Fixed lower clearance conditionCONMED_KETOCONAZOLE0—Binary fixed-context indicator for the lower MMAE clearance multiplier; no perpetrator pharmacokinetics or onset is represented.
Fixed higher clearance conditionCONMED_RIF0—Binary fixed-context indicator for the higher MMAE clearance multiplier; no perpetrator pharmacokinetics or onset is represented.
ADC molecular weightadc_mw_da146664.1DaMolecular weight of the selected ADC.
Systemic clearancecl_l_h0.10969L/hAuthored reconstructed effective ADC clearance for the selected fixed context.
Mean drug antibody ratiodar3.735—Mean molar payload-to-antibody ratio for the selected ADC.
Lower clearance reference multiplierketo_mmae_cl_multiplier0.72464—Fixed lumped MMAE clearance multiplier; its value is set from a reference exposure ratio.
MMAE reference clearancemmae_cl_l_h2.72L/hFixed apparent systemic MMAE clearance used by the conditional model.
MMAE molecular weightmmae_mw_da717.98DaMolecular weight of the MMAE payload.
MMAE reference volumemmae_v_l218.2LFixed 218.2 L reference volume, the rounded 3.03 L/kg times 72 kg conversion.
Intercompartmental clearanceq_l_h0.040504L/hAuthored reconstructed effective ADC intercompartmental exchange clearance.
Higher clearance reference multiplierrif_mmae_cl_multiplier2.12766—Fixed lumped MMAE clearance multiplier; its value is set from a reference exposure ratio.
Central distribution volumevc_l3.4842LAuthored reconstructed effective ADC central distribution volume.
Peripheral distribution volumevp_l1.6225LAuthored reconstructed effective ADC peripheral distribution volume.

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